Hyaluronic Acid Formulation
BOC Sciences combines deep biochemistry and pharmaceutical expertise with exceptional services in hyaluronic acid (sodium hyaluronate) formulation development. We demonstrate extensive expertise in developing sodium hyaluronate formulations while delivering innovative and customized solutions to worldwide clients. Our company delivers precise formulation optimization that specifically meets individual client needs to improve both product effectiveness and safety. In addition, BOC Sciences delivers high-quality services suitable for both small-scale experiments and extensive production runs while adhering to strict market standards.
What is Hyaluronic Acid Formulation?
Hyaluronic acid (HA) functions as a natural polysaccharide found throughout human skin, joints, and eyes. The substance finds extensive application in the cosmetic industry as well as pharmaceuticals and medical devices because it possesses outstanding moisturizing, lubricating, and repair qualities. HA serves as a main ingredient in the cosmetics sector for creams, serums, and masks to deliver intense hydration and repair skin barriers while fighting signs of aging. Medical applications of sodium hyaluronate extend to arthritis treatment as well as ophthalmic surgery procedures and skin regeneration processes. HA formulations require careful consideration of molecular weight, concentration levels, and combined effects with additional components during their design and development. In particular, maintaining exact control over the formulation process is critical for reaching maximum efficacy.
Core Advantages of BOC Sciences in Hyaluronic Acid Formulations
Expert Team
A dedicated R&D team composed of experts in chemistry, pharmacy, and biology, ensuring scientifically advanced and efficient formulation designs.
Customized Formulations
Personalized and tailored sodium hyaluronate formulation services based on specific client requirements.
Advanced Technologies
Utilization of cutting-edge HA modification techniques to optimize formulation efficacy and enhance product performance.
Diverse Applications
Support for the use of HA in cosmetics, pharmaceuticals, and medical devices across multiple industries.
Optimized Process
Comprehensive services from formulation design to product manufacturing, ensuring project efficiency and quality.
GMP Certification
All production activities comply with GMP standards to guarantee product quality and safety.
Analytical Testing
Precise analytical and testing services to ensure each batch meets international quality standards.
Long-Term Collaboration
Extensive experience in HA formulation development, providing ongoing technical support for clients.
Customized Hyaluronic Acid Formulation Design by BOC Sciences
BOC Sciences offers customized sodium hyaluronate formulation design services to meet the specific needs of various industries. The performance of sodium hyaluronate, particularly in terms of molecular weight, viscosity, solubility, and stability, directly affects the efficacy and application of the final product. Therefore, these key factors must be carefully considered during formulation design. Based on client requirements, BOC Sciences provides comprehensive services ranging from HA preparation, HA modification, HA gel preparation to formulation development, ensuring optimal functionality and performance across various applications.
High Molecular Weight Formulations
For products requiring deep hydration and long-lasting lubrication, high molecular weight sodium hyaluronate formulations are available. These formulations exhibit strong gel properties and high adhesion, making them ideal for anti-aging products, skin repair agents, and joint therapy applications.
Low Molecular Weight Formulations
Low molecular weight sodium hyaluronate has a smaller molecular structure, enabling faster penetration into deeper skin layers. This makes it particularly suitable for fast-absorbing skincare products such as serums and masks.
Composite Formulations
To enhance the effects of sodium hyaluronate, composite formulations are available. These combine sodium hyaluronate with functional ingredients such as vitamin C, peptides, and botanical extracts, thereby maximizing its multifunctional benefits.
Sustained-Release Formulations
BOC Sciences offers sustained-release formulation designs that leverage innovative technology to control the release rate of sodium hyaluronate, ensuring prolonged and stable effects over time.
Hydrophilic and Lipophilic Formulations
Sodium hyaluronate formulations can be adjusted to be hydrophilic or lipophilic depending on product application needs. For instance, in oil-based or cream formulations, sodium hyaluronate can be modified to increase solubility and stability in oil-based matrices.
Active Ingredient-Enhanced Formulations
To boost the efficacy of sodium hyaluronate, BOC Sciences integrates it with other active ingredients such as antioxidants and anti-inflammatory compounds. For example, sodium hyaluronate combined with Centella Asiatica extract promotes skin repair and soothing effects.
Medical-Grade Formulations
BOC Sciences provides medical-grade sodium hyaluronate formulation design, particularly for applications in ophthalmic surgery, arthritis treatment, and wound healing. These formulations are designed to meet stringent clinical requirements, ensuring controlled drug release, stability, and biocompatibility.
Multifunctional Hybrid Formulations
Beyond basic hydration and anti-aging benefits, sodium hyaluronate can be incorporated into multifunctional formulations with additional active ingredients. BOC Sciences' hybrid formulation services enhance sodium hyaluronate's original effects, achieving broader skincare benefits tailored to specific industry demands.
Active Ingredients Supported by BOC Sciences in Hyaluronic Acid Formulations
As mentioned above, to further enhance the functionality of sodium hyaluronate, BOC Sciences incorporates other active ingredients into formulations based on customer requirements, such as plant extracts, antioxidants, and vitamins. These additives can work synergistically with sodium hyaluronate to improve the overall effectiveness of the product. For example, in cosmetic formulations, combining sodium hyaluronate with antioxidants like vitamins C and E can effectively combat aging and enhance skin barrier repair. In pharmaceutical products, the combination of sodium hyaluronate with certain active drug ingredients can improve drug efficacy and stability. Our active ingredients include, but are not limited to:
Vitamin C Vitamin E Vitamin B Oligopeptides Hexapeptides Carnosine Niacinamide Amino acids Nucleic acids Centella asiatica extract Green tea extract Aloe vera extract Glycerol Propylene glycol Hydroxyethyl cellulose Steroids Antibiotics Nanoparticles Liposomes Microspheres Inorganic salts Allantoin Trehalose Coenzyme Q10
GMP Large-Scale Manufacturing Capability of BOC Sciences
With advanced GMP manufacturing capabilities, BOC Sciences guarantees the high quality, stability, and traceability of sodium hyaluronate products, meeting the rigorous standards of the global pharmaceutical, cosmetic, and biopharmaceutical industries. Our GMP-compliant production facilities are equipped with sterile environments, high-precision reaction equipment, and automated production lines, enabling seamless transition from small-scale trials to pilot and large-scale production. During manufacturing, we strictly adhere to GMP regulations and international standards, covering raw material selection, formulation optimization, aseptic production, quality testing, and packaging storage to ensure product safety and consistency. Additionally, our production system supports large-scale batch manufacturing, providing customized production from gram-scale to ton-scale to meet diverse customer needs.
Rigorous Quality Control of Hyaluronic Acid Formulations
BOC Sciences is committed to providing high-quality sodium hyaluronate formulation development services, with analysis, testing, and quality control being core steps to ensure each product meets strict standards. As a sensitive and highly effective active ingredient, sodium hyaluronate must maintain stability, purity, concentration, and biocompatibility throughout the formulation process. To guarantee the safety and efficacy of the products required by customers, BOC Sciences employs advanced analytical testing technologies and rigorous quality control measures, ensuring that each batch of sodium hyaluronate products meets industry standards and specific customer requirements.
Analytical Platforms
High-Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) Ultraviolet-Visible Spectroscopy (UV-Vis) Gel Permeation Chromatography (GPC) Dynamic Light Scattering (DLS) Infrared Spectroscopy (IR) Nuclear Magnetic Resonance Spectroscopy (NMR) Viscometer Total Organic Carbon Analyzer (TOC) Differential Scanning Calorimetry (DSC)
Analytical Items
Molecular weight detection Purity analysis pH measurement Solubility testing Viscosity measurement Rheological performance testing Microbial testing Stability testing Biocompatibility testing Hydration effect testing
Service Workflow
Research and Production Applications Supported by Our Formulation Services
BOC Sciences' HA formulation development services support a wide range of research and production applications, including but not limited to the research and development of skincare products, formulation design for ophthalmic drugs and medical devices, customized formulations for joint health products, and the optimization of drug delivery systems. Our services meet full-cycle needs from basic research and clinical trials to large-scale production, providing clients with one-stop HA sodium formulation solutions.
Skincare
HA is widely used in skincare products for its excellent moisturizing properties, skin barrier repair, and anti-aging effects. BOC Sciences supports HA sodium formulation design for various skincare products, helping enhance product efficacy and market competitiveness.
Ophthalmic Treatments
HA plays a crucial role in ophthalmic applications by providing hydration and lubrication, commonly found in eye drops and ointments. BOC Sciences offers high-quality HA sodium formulation support to ensure product biocompatibility and therapeutic effectiveness.
Joint Care
HA sodium is used in arthritis treatments and joint fluid injections for lubrication and pain relief. BOC Sciences designs tailored HA formulations based on client needs to enhance the efficacy and stability of joint care products.
Wound Healing
HA sodium promotes cell regeneration and accelerates wound healing. BOC Sciences provides HA sodium formulation services to ensure the bioactivity and effectiveness of wound healing products.
Aesthetic Injections
HA is extensively used in facial fillers and wrinkle removal products. BOC Sciences offers formulation design for HA injectables, meeting the industry's high requirements for product stability and safety.
Medical Dressings
HA sodium is incorporated into medical dressings to promote wound healing and maintain optimal moisture levels. BOC Sciences provides customized formulation services to meet diverse medical dressing applications.
Drug Carriers
As a drug carrier, HA sodium improves drug stability and controlled release in the body. BOC Sciences provides formulation design for HA sodium in drug delivery systems, optimizing drug bioavailability and effectiveness.
Cosmetics
HA sodium is commonly used in moisturizing, anti-aging, and repair-focused cosmetics. BOC Sciences offers a range of HA sodium formulation services, assisting clients in developing stable and effective beauty products for the market.
FAQs
How to formulate a hyaluronic acid serum?
The formulation of a hyaluronic acid serum typically includes hyaluronic acid sodium as the primary moisturizing ingredient, supplemented with humectants such as water, glycerin, or propylene glycol to enhance hydration. Additional ingredients like vitamin B5, niacinamide, or antioxidants may be added to boost efficacy. The formulation should maintain a pH range of 5.0–7.0 for stability. Low-molecular-weight HA penetrates the skin for deep hydration, while high-molecular-weight HA forms a moisture-locking barrier. Homogenization and aseptic filling ensure the production of a high-performance hyaluronic acid serum.
How do you manufacture hyaluronic acid?
Hyaluronic acid is primarily produced via microbial fermentation. Engineered strains of bacteria, such as Streptococcus or Escherichia coli, are cultivated in a specialized medium to synthesize hyaluronic acid. The fermentation broth undergoes ultrafiltration, precipitation, purification, and drying to obtain high-purity HA. This method offers high yield, strong controllability, and no risk of animal-derived contamination. The final product is commonly converted into its sodium salt form (hyaluronic acid sodium) for applications in skincare, pharmaceuticals, and medical fields.
What ingredient makes hyaluronic acid?
Hyaluronic acid (HA) is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucosamine units. These units are linked via β-1,3 and β-1,4 glycosidic bonds, forming a highly hydrophilic polymer with exceptional water retention capacity. Naturally present in the skin, synovial fluid, and connective tissues, hyaluronic acid plays a vital role in maintaining tissue hydration and lubrication, making it highly valuable in cosmetic and biomedical applications.
What is the best percentage of hyaluronic acid to use?
The optimal concentration of hyaluronic acid depends on its molecular weight and intended application. In general, skincare formulations contain 0.1%–2% hyaluronic acid. A concentration of 0.1%–0.5% is suitable for lightweight hydration products, while 1%–2% provides enhanced moisture retention and repair effects. High-molecular-weight HA (>1000 kDa) forms a protective skin barrier, whereas low-molecular-weight HA (<50 kDa) penetrates the skin for deep hydration.