Polynucleotide In Vitro and In Vivo Testing
BOC Sciences focuses on providing high-quality salmon polynucleotide (PN) support services to global clients. With our extensive experience in drug development, biomaterials, and functional active substances, we have established a comprehensive PN testing platform that covers the entire research process, from cell experiments to animal models. Our in vitro and in vivo testing services not only comply with GMP preclinical research standards but also support functional verification, safety assessments, metabolic studies, and efficacy evaluations. We are committed to helping clients accelerate the preclinical development and registration of PN products in the cosmetics and medical aesthetics sectors.
What is a Polynucleotide?
Polynucleotides (PN) are macromolecular compounds composed of multiple nucleotide monomers connected by phosphodiester bonds. They are the basic structural units of genetic materials such as DNA and RNA. In application, PN typically refers to DNA fragments extracted from the sperm of salmon or other aquatic organisms. These fragments exhibit high biocompatibility and low immunogenicity, making them safely absorbable and utilizable by the human body. Studies have shown that PN has significant biological activity in tissue repair, anti-inflammatory, antioxidant, promoting cell proliferation, and collagen synthesis, particularly in skin tissue engineering and regenerative medicine. In the cosmetics and medical aesthetics sectors, PN is widely used in skin injection fillers, post-surgical repair dressings, anti-aging serums, face masks, and functional skincare products to improve wrinkles, enhance skin elasticity, repair sunburn and post-surgical wounds, and reduce scars. As research progresses, the functional mechanisms and application scope of PN continue to expand, and it is gradually becoming an essential component of modern biomaterials.
Advantages of BOC Sciences in Polynucleotide Testing
Rich Experience and Technical Expertise
BOC Sciences has extensive experience in PN studies, offering reliable in vitro and in vivo functional verification, ingredient analysis, and more.
Comprehensive Evaluation System
We've established a thorough evaluation system, covering physicochemical property testing, bioactivity screening, and animal validation to ensure scientific support for PN product safety and efficacy.
Diverse Animal Models
Our diverse animal models, including skin barrier damage, ultraviolet aging, and wound repair, simulate in vivo PN effects, meeting preclinical research needs.
GMP-Compliant Laboratory System
Our labs adhere to international GMP standards, providing standardized data for drug registration, cosmetic filings, and other regulatory needs, ensuring full compliance.
Flexible and Customized Testing Solutions
We offer flexible, customized testing services tailored to client product categories and market demands, ensuring efficient solutions for diverse R&D needs.
High-Throughput Cell Platform
Our high-throughput platform supports simultaneous screening and testing of multiple samples, enhancing the efficiency and data output for PN antioxidant and anti-inflammatory evaluations.
Interdisciplinary Team
Our team of experts in cell biology, pharmacology, and immunology collaborates to explore PN mechanisms, providing scientific evidence for product development.
Full-Process Project Management System
Our professional project managers oversee projects from start to finish, ensuring controlled timelines, reliable data, and efficient communication throughout.
In Vitro Testing Services for Polynucleotide by BOC Sciences
BOC Sciences has rich experience in PN in vitro testing services, providing clients with comprehensive and customized testing solutions. Our in vitro testing platform covers all aspects of the research process, from cell experiments to molecular mechanism studies, aiming to help clients gain an in-depth understanding of PN's biological activity and efficacy. We use advanced techniques and diverse cell models to evaluate PN, ensuring that each study provides reliable and accurate experimental data. Whether in skincare, anti-aging, or other functional fields, BOC Sciences provides specialized, detailed in vitro assessments according to different needs.
Cell Proliferation and Migration Detection
Using CCK-8 and EdU labeling methods, we assess the promoting effects of PN on cell proliferation and migration. These tests help us understand the potential effects of PN in cell regeneration and repair processes.
Antioxidant and Anti-inflammatory Evaluation
We use flow cytometry and ELISA technology to detect the inhibition effects of PN on intracellular oxidative stress responses and inflammatory factors (e.g., TNF-α, IL-6), analyzing its antioxidant and anti-inflammatory properties.
Three-Dimensional Skin Model Analysis
We use 3D skin tissue models to assess the role of PN in skin repair and anti-aging, simulating its function and effects in a real skin environment, especially its promotion of skin barrier repair.
Collagen Synthesis Detection
Through qPCR and Western blot analyses, we evaluate the effect of PN on collagen synthesis in fibroblasts, studying its potential applications in anti-aging and skin elasticity enhancement.
Cellular Biodegradability Assessment
We test the stability and degradability of PN within cells, ensuring its safety and long-lasting effects in both in vitro and in vivo use. This test is crucial for understanding the biocompatibility of PN.
Combined Active Ingredient Evaluation
We conduct combined tests of PN with other common active ingredients (e.g., vitamin C, peptides) to assess their synergistic effects, optimizing product formulations and enhancing their effects.
PN Uptake and Intracellular Distribution
We measure the absorption rate and intracellular distribution of PN in different cell types, analyzing its ability to penetrate cell membranes and distribute within cells, ensuring its efficacy in living organisms.
Long-Term Stability and Toxicity Screening
We evaluate the stability of PN samples under long-term storage conditions, while conducting acute and chronic toxicity screenings to ensure the safety and long-term effectiveness of the product.
In Vivo Testing Services for Polynucleotides by BOC Sciences
BOC Sciences offers a wide range of in vivo testing services for PN, focusing on evaluating their biological effects, distribution, metabolism, and safety in animal models. Through precise in vivo experimental design, we are able to gain a deeper understanding of PN's pharmacokinetic characteristics and its effects in various tissues and organs. These studies provide strong data support for the application of PN in drug development, clinical translation, and other related fields. Our in vivo testing services cover the following areas:
Pharmacokinetic Studies
We evaluate the absorption, distribution, metabolism, and excretion processes of PN through animal in vivo experiments to help determine its efficacy and safety.
Tissue Distribution and Targeting Tests
By analyzing tissue samples, we assess the distribution of PN in various tissues and organs, providing data support for targeted drug development and precision treatment.
Chronic Toxicity Testing
We conduct long-term toxicity assessments at different doses, monitoring the potential effects of PN on animal health during prolonged administration, ensuring its safety.
Immunogenicity Evaluation
We evaluate the immune response triggered by PN in vivo to ensure its low immunogenicity and avoid potential immune rejection and allergic reactions.
Skin Penetration and Local Effect Testing
Through skin models or animal experiments, we study the penetration and biological effects of PN in local applications, widely applied in cosmetics and skin care product development.
Polynucleotide Product Categories Supported by Our Testing Services
BOC Sciences provides comprehensive PN product testing services, covering various PN products such as raw materials, formulations, injectables, and gels, ensuring that each product meets strict quality standards during the R&D and application process. Our testing services include efficient raw material testing, formulation optimization, and stability evaluation, as well as performance and safety testing for different dosage forms. With advanced analytical platforms, including HPLC, MS, and NMR, we precisely determine the purity, structure, and biological activity of PN. Additionally, we conduct rigorous pharmacodynamic, safety, and biocompatibility assessments for injectables and gels, ensuring the feasibility of products in preclinical and clinical research. Whether in skin care, anti-aging, drug delivery, or other applications, BOC Sciences provides comprehensive, customized PN product testing services, supporting clients in accelerating R&D, optimizing formulations, and ensuring the efficacy and safety of final products.
Advanced Animal and Cell Platforms for In Vitro and In Vivo Testing
BOC Sciences is equipped with top-tier animal and cell experimental platforms, dedicated to providing accurate and efficient experimental support for PN product development. Our platforms combine advanced animal models and cell culture technologies to comprehensively assess the biological activity, safety, and efficacy of PN both in vivo and in vitro. Whether for drug delivery, skin repair, or other biomedical applications, our animal models can precisely simulate the physiological environment of the human body, helping clients fully understand the biocompatibility, metabolism, and therapeutic effects of PN. Furthermore, our cell experimental platforms include various cell types, such as epithelial cells, immune cells, and more, allowing us to evaluate the mechanisms and effects of PN at the cellular level. These platforms not only support basic biological research of PN but also provide critical data for preclinical testing, ensuring that product development meets high industry standards.
Cell Platforms
Fibroblast Cell Lines Keratinocyte Cell Lines Endothelial Cell Lines Immune Cell Lines Nerve Cell Lines Adipocyte Cell Lines
Animal Platforms
Mouse Models Rat Models Rabbit Models Pig Models Dog Models Monkey Models
Advanced Analytical Testing Platforms for In Vitro and In Vivo Testing
BOC Sciences offers high-precision PN testing services through its advanced analytical testing platforms, ensuring the quality and stability of products during the development process. Our platforms integrate the latest analytical technologies, including HPLC, MS, NMR, and more, enabling in-depth analysis of PN's structure, purity, and metabolites, providing scientific data for product optimization and quality control. Additionally, our laboratories possess strong data processing capabilities, allowing for rapid analysis and interpretation of experimental results to help clients efficiently resolve challenges during the R&D process. Through these advanced analytical testing platforms, we can not only precisely determine the molecular characteristics of PN but also provide detailed data on its biological activity, stability, and reactivity in various applications, ensuring its broad applicability in cosmetics, pharmaceuticals, and other industries.
High-Performance Liquid Chromatography (HPLC) Capillary Electrophoresis (CE) Mass Spectrometry (LC-MS/MS) Ultraviolet Spectrophotometer Fluorescence Quantitative PCR (qPCR) Enzyme-Linked Immunosorbent Assay (ELISA) Flow Cytometry (FACS) Microscopic Imaging Systems
Polynucleotide Applications in Cosmetics and Medical Aesthetics
PN, as a highly safe and powerful natural biological material, has been widely used in high-end cosmetics and medical aesthetic products in recent years, becoming one of their core ingredients. The unique biological activity of PN makes it highly effective in skin care, particularly in anti-aging, post-surgery repair, and skin whitening. Below are typical applications of PN in cosmetics and medical aesthetics:
Anti-Aging Skin Care
PN promotes cell renewal and collagen production, enhancing skin elasticity, reducing fine lines and sagging, and is widely used in facial serums, eye creams, and other anti-aging products to help restore youthful skin.
Post-Surgery Repair
PN accelerates skin barrier repair and dermal regeneration, widely used after laser, radiofrequency, and mesotherapy procedures, helping to quickly repair damaged skin and reduce redness and sensitivity.
Whitening and Brightening
PN improves skin tone and reduces dullness by reducing inflammation and inhibiting melanin production, commonly found in whitening products, helping to even out skin tone and restore skin radiance.
Injectable Aesthetics
PN, used as a skin injection filler, improves skin firmness and hydration, enhancing skin elasticity and giving it a smoother, fuller appearance with long-lasting effects.
Medical-Grade Skin Care Products
PN is effective in alleviating inflammation in sensitive skin conditions such as dermatitis and eczema, reducing allergic reactions, and promoting skin health, suitable for medical-grade skin care products.
Skin Cell Regeneration
By stimulating the activity of endogenous skin cells, PN helps promote metabolism and cell renewal, keeping skin smooth and firm, improving overall skin condition.
Anti-Inflammatory and Soothing Skin Care
PN regulates immune responses in the skin, reducing inflammation and alleviating symptoms of skin allergies, redness, and swelling, widely used in sensitive skin care.
Antioxidant Properties
PN has strong antioxidant properties, capable of eliminating free radicals and reducing damage caused by environmental pollutants and ultraviolet rays, helping to maintain skin health and vitality.
FAQs
What are polynucleotide injections?
Polynucleotide injections are a therapeutic method in which polynucleotides are the main component. Polynucleotides are biopolymers made up of multiple nucleotide units, usually derived from natural sources like salmon. They possess powerful repair and regeneration capabilities, promoting cell repair and renewal, improving skin elasticity and hydration. Polynucleotide injections are primarily used for anti-aging, skin repair, and post-surgery recovery, accelerating skin barrier repair and improving skin health and appearance by reducing fine lines and sagging.
What are polynucleotides in aesthetics?
In aesthetics, polynucleotides are commonly used for anti-aging and skin repair. They promote skin cell regeneration and collagen synthesis, improving skin elasticity, firmness, and hydration. Polynucleotides are widely applied in injectable aesthetics, especially in facial serums, eye creams, and other products, accelerating skin cell repair, reducing fine lines and sagging, and achieving skin beautification and anti-aging effects.
Are polynucleotides skin boosters?
Yes, polynucleotides can be used as skin boosters. They promote skin cell renewal, enhance collagen synthesis, and improve skin elasticity and hydration through injection. As skin boosters, polynucleotides nourish the skin deeply, increasing skin firmness, and improving dullness and roughness. Their powerful repair function makes them a common aesthetic treatment to restore youthful skin radiance.