Polynucleotide Gel Development
Against the backdrop of rapid advancements in skin regenerative medicine and biomaterials applications, polynucleotide (PN) gel, as an innovative material with high biocompatibility, excellent hydration properties, and multiple biological functions, is gaining widespread attention. Leveraging its profound expertise in nucleotide derivative preparation and polymer gel system development, BOC Sciences offers comprehensive services for the development and preparation of PN gel. We provide one-stop solutions for research institutions, pharmaceutical companies, and medical device manufacturers, covering everything from raw material customization, formulation development, and structural optimization to GMP-grade scale-up production and quality testing. Our services support product development needs in medical aesthetics, tissue engineering, dermatological therapies, and other fields.
What are Polynucleotides?
Polynucleotide (PN) gel is a high-molecular-weight hydrogel material prepared from natural DNA fragments through processes such as extraction, purification, and shearing. It is primarily derived from fish tissues such as salmon and possesses excellent biocompatibility and biodegradability. The DNA strands in PN gel are rich in phosphate groups, giving them strong hydrophilicity and polymerization ability, which enables the formation of a three-dimensional network structure. This significantly enhances its water retention capacity, structural stability, and biological activity. PN not only acts as a physical filler to improve tissue structure but also enhances tissue repair and regeneration by stimulating fibroblast proliferation and promoting collagen synthesis. Thanks to its natural origin, low immunogenicity, and excellent tissue integration, PN gel has been widely applied in aesthetic injections, wound healing, post-surgical repair, scar softening, and stretch mark improvement. In recent years, its potential in tissue engineering scaffolds, biomaterial coatings, and drug sustained-release systems has been increasingly explored, providing a strong material foundation for regenerative medicine, medical aesthetics, and medical device development.
Advantages of BOC Sciences in Polynucleotide Gel Development
High Purity of Raw Materials
We use high-quality fish-derived DNA raw materials to ensure high PN purity, low impurity levels, and strong biosafety.
Customized Formulation Design
We develop PN gels of varying concentrations and types according to client needs, meeting diverse clinical and cosmetic applications.
Advanced Shearing Technology
Controlled enzymatic and physical shearing processes allow precise control of PN chain length, improving gel uniformity and functionality.
Multi-Component Blending Capability
We have mature technologies for blending PN with materials such as sodium hyaluronate, sodium carboxymethyl cellulose (CMC-Na), and gelatin to enhance product performance.
Coordinated Structure-Function Optimization
By regulating crosslinking and network structure, we achieve a balanced coordination of gel strength, hydration, and biological activity.
GMP-Grade Manufacturing Platform
Equipped with GMP-compliant pilot and commercial-scale production lines, we support clinical and commercial-scale batch manufacturing.
Comprehensive Quality Control
A quality control system covering raw materials, formulations, and finished products is in place, along with high-sensitivity analytical instruments to ensure product consistency.
International Regulatory Support
We provide regulatory data support and registration consultation services that comply with FDA, EMA, and other regulations to assist global product launches.
Polynucleotide Gel Development Services by BOC Sciences
BOC Sciences has accumulated extensive experience and technical expertise in PN gel development, offering end-to-end services from concept to final product. Our PN gel development services aim to deliver efficient, flexible, and personalized solutions based on market demands and client requirements. Whether in the preclinical research stage or commercial production phase, we ensure product quality and production efficiency.
Self-Gelling PN Solution Development
By precisely controlling the concentration and molecular weight of PN, we design solutions with excellent rheological properties and high gel strength to suit various application scenarios.
Sodium Hyaluronate Composite Gel Development
BOC Sciences offers development of sodium hyaluronate (HA) composite PN gels, combining HA's moisturizing effects with PN's regenerative and reparative functions.
Sodium Carboxymethyl Cellulose (CMC-Na) Composite Gel Development
As a natural polysaccharide, CMC-Na enhances the gel's stability and structural strength when blended with PN, while prolonging its action time on the skin surface.
Gelatin Composite Gel Development
Gelatin combined with PN gel can enhance its mechanical properties and toughness, making it suitable for wound healing, skin filling and reconstructive surgery.
Polynucleotide Gel Preparation Technology Platform
BOC Sciences possesses a world-class technology platform capable of providing comprehensive support from small-scale experiments to large-scale production based on customer needs. Our PN gel preparation technology involves multiple key stages, including raw material screening, formulation design, structural optimization, and functional enhancement. Each stage is strictly controlled to ensure the quality and stability of the final product. In addition, BOC Sciences offers full technical support to guarantee a smooth transition from laboratory to commercial production, while maintaining batch-to-batch consistency and efficient manufacturing.
Raw Material Screening and Purification
We extract high-purity PN from carefully selected deep-sea fish and employ advanced molecular screening and column chromatography techniques to ensure high purity and low impurity levels of raw materials. All raw materials undergo rigorous quality testing to meet biomedical standards.
Gel Formulation Design
Tailored PN gel formulations are designed based on different application scenarios. We precisely adjust the gel matrix, PN concentration, buffer systems, pH levels, and excipient ratios to ensure stability, rheological properties, and biodegradability of the gels.
Structural Optimization and Physicochemical Property Adjustment
Through crosslinking modifications of PN gel molecular chains, we optimize the structure and control the properties of the gel. Mechanical strength, adhesiveness, and biodegradability are finely tuned, enhancing the gel's biocompatibility and stability across different tissues.
Function Enhancement and Multi-Component Synergy
Our technical team can synergistically combine PN with other bioactive components such as antioxidants, cytokines, and peptides to enhance biological functions like anti-aging, wound healing, and cell proliferation.
GMP-Scale Manufacturing Capability of Polynucleotide Gel
At the laboratory scale, BOC Sciences prepares homogeneous PN gels through high-shear emulsification, ultrasonic dispersion, and magnetic stirring. To ensure feasibility for large-scale production, we simultaneously conduct pilot-scale process evaluations, standardizing key steps such as stirring speed, temperature control, shear strength, vacuum defoaming, and aseptic filling. Our GMP-certified manufacturing facilities comply with international standards and strictly follow the ISO quality management system, ensuring that every batch meets pharmaceutical and cosmetic-grade requirements. We implement full-process quality control from raw material sourcing, formulation design, production process, to final product testing, with every step rigorously validated and reviewed. Furthermore, to address gel storage stability issues, BOC Sciences has developed various dosage forms such as cold storage, freeze-dried formulations (lyophilized powder + diluent packaging), and prefilled syringes. These approaches extend product shelf life while ensuring that active ingredients remain undegraded and unaggregated before and after use, enhancing both safety and convenience.
Quality Testing Services for Polynucleotide Gel by BOC Sciences
BOC Sciences offers comprehensive PN gel quality testing services to ensure every batch meets the highest quality standards. Our testing team utilizes advanced technologies and equipment, rigorously adhering to international quality control norms to guarantee product safety, efficacy, and stability. We provide a detailed range of analytical services, including physicochemical property testing, microbiological testing, and stability evaluations, ensuring strict quality compliance throughout R&D, manufacturing, and storage processes. Our goal is to offer efficient and reliable quality testing services that help clients achieve quality control and regulatory compliance.
Testing Equipment Platform
High-Performance Liquid Chromatograph (HPLC) Mass Spectrometer (MS) UV-Visible Spectrophotometer (UV-Vis) Differential Scanning Calorimeter (DSC) Fourier Transform Infrared Spectrometer (FTIR) Nuclear Magnetic Resonance Spectrometer (NMR) Dynamic Light Scattering Instrument (DLS) Microbiological Testing System Particle Size Distribution Analyzer (Laser Diffraction) Gas Chromatograph (GC)
Analytical Items
Molecular Weight Distribution Analysis (GPC/SEC) Purity and Impurity Detection (HPLC, UV, MS) pH and Viscosity Testing Gel Strength and Rheological Property Evaluation Moisture Content and Hydration Rate Determination Endotoxin Testing (LAL) Sterility Testing Cytotoxicity Evaluation (MTT) Fibroblast Proliferation Assay Free Radical Scavenging Ability Test (DPPH Method)
Applications of Polynucleotide Gel in Aesthetic and Medical Treatments
As an innovative biomaterial, PN gel demonstrates broad application potential due to its excellent hydrophilicity, regenerative ability, and biocompatibility. Whether in the beauty industry or in medical treatment and tissue repair, PN gel has become an indispensable element in modern therapies and skincare due to its outstanding efficacy and multifunctionality. It promotes skin regeneration, anti-aging, enhanced hydration, and improved skin texture, making it widely used in skincare and wound healing. Furthermore, PN gel also plays a crucial role in medical fields such as wound healing, scar treatment, and tissue engineering. With technological advancement, the application of PN gel continues to expand, becoming a key material for innovation and product performance enhancement across various industries. By understanding its diverse applications, clients can better leverage its advantages to develop effective products and meet the growing market demand.
Skin Regeneration and Repair
PN gel shows significant effects in skin regeneration and repair. It promotes the generation of collagen and elastin, accelerates wound healing and skin restoration, and is widely used in facial care, skin damage, and wound healing applications, significantly improving skin texture and elasticity.
Anti-Aging and Hydration
PN gel improves skin hydration and antioxidant capacity, enhancing smoothness and elasticity while slowing the aging process. It is suitable for moisturizing care of dry and aging skin, making the skin appear firmer, plumper, and younger, and is an essential component in cosmetic skincare products.
Scar Repair
PN gel is widely used in scar repair, promoting regeneration of skin tissues and reducing scar formation. Especially for surgical scars and burn scars, it effectively shortens healing time and improves scar appearance, aiding the restoration of normal skin structure.
Stretch Mark Treatment
Stretch mark treatment is one of the common applications of PN gel. It promotes the synthesis of elastic fibers in the skin, helping to repair stretch marks caused by skin stretching. Long-term use can reduce the appearance of stretch marks, restoring smoother and firmer skin.
Wound Healing and Trauma Repair
PN gel accelerates wound healing by promoting the repair and regeneration of new tissue. It forms a protective membrane that maintains a moist wound environment, reduces infection risk, and enhances healing quality. It is widely used in surgical and burn treatments.
Skin Pigmentation Improvement
PN gel effectively improves pigmentation caused by UV exposure or aging. It inhibits melanin production, evens skin tone, and fades spots and pigmentation. Commonly used in whitening products and skincare, it helps restore the skin's natural radiance.
Tissue Engineering and Regenerative Medicine
In tissue engineering and regenerative medicine, PN gel serves as a cell culture medium and scaffold material, providing growth factors and structural support to promote cell growth and differentiation. It offers an ideal environment for the regeneration and repair of damaged tissues, widely used in bone and cartilage tissue repair.
Injectable Filler and Facial Contouring
Due to its excellent biocompatibility and support properties, PN gel is widely used in non-invasive injectable fillers and facial contouring treatments. It fills facial wrinkles and hollow areas, providing a natural filling effect while enhancing the durability of results by promoting the skin's self-repair and regeneration.
FAQs
What are polynucleotides good for?
Polynucleotides are bioactive substances with reparative functions that stimulate cell regeneration, enhance collagen production, and possess strong anti-inflammatory and antioxidant properties. In the aesthetic field, they are widely used to improve skin texture, firm the skin, diminish fine lines, and boost elasticity and radiance. They are also applied in post-operative repair and wound healing. Unlike simple moisturizers or fillers, polynucleotides improve skin health from the root, making them one of the most popular skin regeneration therapies today.
Are polynucleotides better than Botox?
Polynucleotides and Botox serve different purposes and are not directly comparable. Polynucleotides focus on skin repair and regeneration, making them suitable for improving skin texture, enhancing elasticity, and softening static wrinkles. Botox, on the other hand, works by blocking nerve signals to relax facial muscles, targeting dynamic wrinkles. If one seeks natural recovery and long-term conditioning, polynucleotides are preferable. If the goal is to smooth wrinkles quickly, Botox delivers faster results. The two can be used together for enhanced overall effects.
Are polynucleotides the same as fillers?
Polynucleotides are not traditional fillers. They do not work by adding volume for contouring, but instead improve skin quality through cell repair and by boosting collagen and elastin production. They are typically used for overall skin revitalization, addressing issues like enlarged pores, uneven skin tone, and skin laxity. Traditional fillers such as hyaluronic acid mainly address volume loss and shape definition. The two approaches can complement each other, balancing visible enhancement and fundamental skin repair.