Polymer Nanoparticle Development Services

As a leading biopharmaceutical company, BOC Sciences prides on providing best-in-class polymer nanoparticle development services. Our integrated services cover research, development and production, ensuring that our customers receive cutting-edge solutions tailored to their specific needs.

What are polymer nanoparticles?

Polymer nanoparticles are nano-sized particles composed of biodegradable and biocompatible polymers. These particles, which typically range in size from 10 to 1,000 nanometers, are important tools in biomedicine, especially for drug delivery, imaging, and diagnostics. The core structure of polymer nanoparticles is designed to encapsulate therapeutic agents, such as drugs, proteins or nucleic acids. These polymer-based nanoparticles have a wide range of drug encapsulation efficiency, targeting, and stimulus-response properties, allowing them to have multiple strategies in drug delivery. In addition, polyethylene glycol (PEG) is commonly used for surface functionalization of nanoparticles, which imparts mucus penetration to oral nanoparticles, leading to increased penetration of the drug in inflammatory bowel tissue.

Types of polymer nanoparticles

Polymer nanoparticles can be roughly classified according to their structure and composition:

Nanospheres: solid matrix systems in which drugs are uniformly dispersed.

Nanocapsules: core-shell structures in which a polymer shell encloses a liquid or solid core.

Dendrimer: A highly branched tree-like structure with a large number of terminal functional groups.

Polymer micelles: Self-assembled amphiphilic block copolymers form core-shell structures in aqueous environments.

Polymer drug conjugates: Polymer-drug conjugates containing water-soluble biocompatible polymeric backbone and hydrophobic therapeutic agents are widely studied polymer drug delivery platforms.

Fig. 1 Schematic illustration of various potential approaches for triggered drug delivery using polymer-based nanoparticles. (a) Polymer-drug conjugates, (b) Polymeric nanoparticles, (c) A dual-pH-sensitive polymeric micelles from self-assembling of a block copolymer-doxorubicin conjugate and (d) thermo-sensitive shelfcrosslinked micelles. (Hassan, S., 2017)

Polymeric nanoparticles examples

Polyglycolic acid (PGA), polylactic acid (PLA), poly(glycolide-lactide) (PLGA), poly-ε-caprolactone (PCL) and polymethyl methacrylate (PMMA) as synthetic polymers, And natural polymers such as chitosan, alginate, gelatin, collagen, dextran, heparin and albumin are preferred for designing polymer-based nanoparticle based drug delivery. Among these synthetic polymers, PLGA-based nanoparticles have attracted much attention due to their good biocompatibility and drug release tunability. The properties of PLGA, such as molecular weight, drug release rate, hydrophobicity and biodegradability, can be regulated by regulating the lactate-glylactone (L:G) ratio and molecular weight (Mw) of PLGA. Gumusderelioglu et al. investigated the effect of L:G ratios ranging from 70:30 to 90:10 on ametycine release. As the glycolactone content increases, so does the amount and rate of release of the drug. Among natural polymers, chitosan based nanoparticles have become one of the most popular biopolymers in nanomedicine because of their good biocompatibility and biodegradability, low toxicity, adhesion, hemostasis and antimicrobial properties, and simple preparation methods. Chitosan nanoparticles have a strong affinity for negatively charged cell surface and in vivo site-specific drug delivery. The drug released from chitosan nanoparticles is dependent on polymer erosion, polymer-drug interactions, and their swelling degree, which is affected by the pH of the medium

Polymer nanoparticle applications

Drug delivery: Enhance the delivery of therapeutic agents to the target site, improve efficacy and reduce side effects.

Gene therapy: The delivery of genetic material into cells to treat genetic diseases.

Imaging: Used as a contrast agent in imaging techniques such as MRI and CT scans.

Vaccines: Delivery of antigens to induce an immune response.

Cancer therapy: The targeted delivery of anti-cancer drugs to tumor cells.

Tissue engineering: scaffolds for tissue regeneration and repair.

Advantages of polymer nanoparticles

Enhanced stability: Protects the encapsulated substance from degradation.

Controlled release: Continuous and targeted release to reduce the frequency of administration.

Biocompatibility and biodegradability: Many polymer nanoparticles are made from organic materials, such as PLGA (lactic acid-glycolic acid copolymer), which have been shown to be non-toxic to humans and have good biocompatibility. This gives them great potential for biomedical applications such as drug delivery and in vivo imaging.

Targeted delivery: The ability to functionalize surface ligands to achieve cell-specific targeting.

Improve solubility: Improve the solubility and bioavailability of drugs with poor water solubility.

Customizable composition: The composition of polymer nanoparticles can be adjusted and optimized as needed to meet the needs of different applications. This customizability allows them to be used in a variety of fields, including but not limited to biomedicine, electronics, coatings, etc.

Our polymer nanoparticle development services

Our company specializes in providing end-to-end polymer nanoparticle development services. We work closely with our customers to understand their specific needs and provide tailored solutions to address complex biomedical challenges. Here is an overview of the services we offer:

Custom polymer nanoparticle synthesis

We offer customized polymer nanoparticle synthesis using a wide range of biodegradable and biocompatible polymers to meet the unique requirements of each customer. We use a range of cutting-edge technologies, such as solvent evaporation, ion crosslinking and high pressure homogenization, to ensure that the nanoparticles have a consistent and controlled size distribution and high load capacity. Our unique preparation process optimizes particle size and surface properties for different drug properties, resulting in optimal drug release behavior.

Drug packaging and characterization

Our state-of-the-art facility is equipped with advanced analytical tools for comprehensive characterization of polymer nanoparticles. This includes evaluating particle size and distribution, surface charge, morphology, encapsulation efficiency, and release curves. Advanced equipment such as dynamic light scattering (DLS), transmission electron microscopy (TEM) and nuclear magnetic resonance (NMR) were used to fully characterize the prepared nanoparticles. Based on the obtained data, the formulation is optimized to ensure the stability and effectiveness of the nanoparticles in vivo. Combined with high performance liquid chromatography (HPLC) and mass spectrometry (MS), the encapsulation efficiency and release kinetics of drugs were accurately determined.

Surface functionalization and targeting

We focus on surface functionalization of polymer nanoparticles to improve their targeting capabilities. By coupling a targeting ligand, such as an antibody, peptide or aptamer, to the surface, we create nanoparticles that can selectively bind to a specific cell or tissue, thereby improving therapeutic efficacy and minimizing off-target effects.

Advanced instruments

Advantages of our polymer nanoparticle development services

• Top technical support
• Advanced equipment support
• Customized service
• Strict quality control
• Full data support

Our workflow

• Preliminary consultation and needs analysis
• Polymer selection and synthesis
• Preparation of polymer nanoparticles
• Characterization and optimization of polymer nanoparticles
• Evaluation in vitro and in vivo
• Final inspection and report

Polymer nanoparticles represent a transformative approach to drug delivery and biomedical applications, offering unparalleled advantages in targeted delivery, controlled release, and biocompatibility. BOC Sciences is at the forefront of this technology, providing the most advanced polymer nanoparticle development services to meet the specific needs of our customers. Whether enhancing drug solubility, enabling targeted delivery, or developing new formulations, our expertise ensures that we deliver high-quality, innovative solutions to the biopharmaceutical industry.

FAQ

1. What are polymer nanoparticles?

Polymer nanoparticles are tiny particles composed of polymers, ranging in size from 1 to 1000 nanometers. They are used for various applications, particularly in the field of drug delivery, due to their ability to encapsulate active pharmaceutical ingredients and release them in a controlled manner.

2. What services do you offer for polymer nanoparticle development?

We offer comprehensive polymer nanoparticle development services including:

• Formulation development: Customized formulation of polymer nanoparticles based on specific client needs.
• Characterization: Detailed analysis of nanoparticle size, shape, surface charge, and drug encapsulation efficiency.
• Scale-up production: Transition from laboratory-scale production to larger, industrial-scale manufacturing.

3. What polymers do you use for nanoparticle development?

We work with a wide range of polymers, including both natural and synthetic types, such as: PLGA, PCL, chitosan, PMMA, PLA.

4. Can you help with the encapsulation of specific drugs or compounds?

Yes, we specialize in the encapsulation of various drugs and bioactive compounds, including small molecules, peptides, proteins, and nucleic acids. We tailor our encapsulation techniques to ensure optimal drug loading, stability, and release profiles.

5. What methods do you use to prepare polymer nanoparticles?

We utilize a variety of preparation methods to suit different needs, including: Emulsion-solvent evaporation, nanoprecipitation, ionic gelation, spray drying, supercritical fluid technology.

6. How do you ensure the quality and consistency of the nanoparticles?

We adhere to stringent quality control measures throughout the development process. This includes:

• Physicochemical characterization: Analysis of particle size, morphology, and surface charge.
• Drug release studies: In vitro and in vivo testing to assess drug release profiles.
• Stability testing: Evaluation of nanoparticle stability under various storage conditions.

7. Do you offer customization options for nanoparticle formulations?

Absolutely! We understand that each project is unique, and we work closely with our clients to develop customized nanoparticle formulations that meet their specific requirements. This includes modifying the polymer type, particle size, drug loading capacity, and release characteristics.