Polymethyl Methacrylate (PMMA) Services
BOC Sciences focuses on providing high-quality, customizable polymethyl methacrylate (PMMA) preparation and development services to clients in industries such as biomedicine, cosmetics, and aesthetic medicine. We are committed to the research and development of PMMA materials of different grades, including medical-grade, injectable-grade, cosmetic-grade, and industrial-grade PMMA microspheres, to meet diversified requirements for particle size, dispersibility, biocompatibility, and stability across various application scenarios. By combining advanced synthetic processes with a rigorous quality control system, BOC Sciences delivers safe, efficient, and scalable PMMA solutions to support innovative product development and market applications.
What does PMMA Stand For?
PMMA is a thermoplastic material polymerized from methyl methacrylate monomers, characterized by high transparency, light weight, and high strength. In practical applications, PMMA is often developed in the form of microspheres for use in pharmaceutical and cosmetic products. PMMA microspheres offer advantages such as controllable particle size, good dispersibility, structural stability, and surface modifiability. Particle sizes can be adjusted as needed (typically from 100 nm to 800 μm), and bioactivity or drug-loading capacity can be imparted through surface modification. Their smooth surface and uniform spherical shape also contribute to excellent sensory properties and safety. In the biomedical field, the biocompatibility and stability of PMMA microspheres make them ideal implant materials, for example, in dental restorations and orthopedic surgeries. In cosmetics and aesthetic medicine, PMMA microspheres are widely used due to their durability and safety. They can be used as dermal fillers to reduce wrinkles and scars and to enhance facial contours. Moreover, PMMA microspheres can be customized for various applications by adjusting their size and surface properties, such as serving as carriers in drug delivery systems. These features make PMMA microspheres highly valuable across multiple fields.
Advantages of PMMA Services at BOC Sciences
Controllable Particle Size
Equipped with precise regulation technology, we offer synthesis services for PMMA microspheres ranging from 100 nm to 800 µm.
Narrow Particle Size Distribution
Highly monodisperse microspheres ensure consistency in particle size, enhancing formulation stability and product uniformity.
Surface Modifiability
Supports the introduction of various functional groups to meet needs such as drug conjugation, targeted modification, and enhanced biocompatibility.
High-Purity Preparation
Employs precise purification processes to remove residual monomers and by-products, ensuring compliance with medical and cosmetic standards.
Scalable Processes
Smooth transition from lab-scale R&D to pilot-scale production, supporting scale-up from gram to kilogram levels.
Customized Solutions
Offers multi-dimensional customization solutions for particle size, structure, and surface properties according to specific client applications.
GMP Compliance
Features a GMP-compliant production environment and management system to meet the regulatory requirements for medicinal and injectable-grade products.
Versatile Formulation Support
Applicable in the formulation development and process optimization of emulsions, gels, powders, injectables, and other dosage forms.
PMMA Development Services Provided by BOC Sciences
BOC Sciences focuses on the preparation and formulation development of high-performance PMMA products for industries including biomedicine, cosmetics, and aesthetic medicine, with integrated capabilities from R&D to scalable production. With years of experience in polymer materials research and an advanced microsphere manufacturing platform, we offer PMMA microsphere products with uniform particle sizes, stable structures, and tunable surfaces tailored to diverse application needs. These are widely used in tissue fillers, sustained-release carriers, skincare, cosmetics, and aesthetic injectables. Our services cover multiple dimensions such as PMMA microsphere preparation and modification, formulation optimization, and functional filler design. We have particularly strong capabilities in particle size control, dispersibility, surface activity, and biocompatibility of polymer microspheres. BOC Sciences is committed to high-standard quality control and flexible customized support to provide PMMA products and solutions meeting various standards including medical-grade, injectable-grade, and cosmetic-grade, driving the innovative application of new materials in advanced medical and cosmetic fields.
PMMA Microsphere Preparation Services
We provide monodisperse PMMA microspheres with particle sizes ranging from 100 nm to 800 µm, suitable for various applications. Depending on the application, microspheres can be designed as solid, hollow, or porous structures, with controlled morphology consistency and dispersibility.
PMMA Microsphere Modification Services
We offer surface modification services including carboxylation, amination, PEGylation, fluorescent labeling, and bioligand conjugation, enhancing dispersibility, biocompatibility, drug-loading capacity, or targeting ability. Additionally, we can render the microspheres hydrophilic or hydrophobic to suit different solvent systems.
PMMA Formulation Development Services
BOC Sciences has a professional team for cosmetic and aesthetic formulation development, supporting PMMA formulation design in various carriers (such as gels, suspensions, powders, and injectables). We specialize in developing cosmetic formulations with stable light-scattering properties and optimized skin feel, helping clients accelerate product registration and commercialization.
PMMA Filler Development Services
We provide the aesthetic industry with formulation and process development for long-lasting PMMA fillers, including microsphere concentration control, injectable suspension system construction, biocompatibility validation, and injectability assessment. These filler products achieve desired aesthetic outcomes while ensuring safety and tissue integration.
GMP Manufacturing Capability of PMMA
BOC Sciences operates GMP production facilities that comply with international standards, equipped with advanced polymer reaction equipment and sterile production environments to fully meet the strict quality and regulatory requirements for medical-grade, injectable-grade, and cosmetic-grade PMMA products. Our GMP workshops are certified under multiple international quality systems, covering key stages such as raw material handling, polymerization, microsphere washing and drying, and sterile packaging, ensuring batch-to-batch consistency and traceability. Thanks to a flexible manufacturing system, we can provide scalable solutions from gram-level R&D and pilot validation to kilogram- and ton-scale commercial production. Whether it's for small-batch customization for early-stage research or large-scale production for clinical or market promotion, we deliver efficient, safe, and compliant manufacturing support to help clients rapidly translate innovative PMMA formulations into high-quality end products and accelerate product launch.
PMMA Quality Control Testing Services by BOC Sciences
BOC Sciences is equipped with a state-of-the-art analytical testing platform and a professional quality management system to provide customers with comprehensive, accurate, and traceable PMMA quality testing and characterization services. Our laboratories feature advanced instruments including HPLC, GC-MS, FTIR, NMR, particle size analyzers, Zeta potential analyzers, scanning electron microscopes (SEM), and thermal analyzers (DSC/TGA), enabling complete analysis of PMMA microsphere structure, particle size distribution, purity, and safety. For medical- and cosmetic-grade PMMA, we also offer GMP- and ISO-compliant full test reports, raw data, COA, MSDS, and technical documents for research or registration use, supporting compliance with product filing, quality audits, and regulatory submissions. Beyond standard physicochemical tests, we conduct in vitro and in vivo safety and biocompatibility studies to help customers fully understand product performance and ensure reliability and safety in end-use applications.
PMMA Quality Testing Services
Particle size distribution analysis Surface charge (Zeta potential) analysis Microsphere morphology characterization (SEM) Residual monomer analysis Molecular weight distribution (GPC) Chemical structure confirmation (FTIR/NMR) Moisture content analysis (Karl Fischer) Thermal stability testing (TGA/DSC) Impurity analysis pH and solution stability testing
In Vitro and In Vivo Testing Services
Cytotoxicity testing Hemocompatibility testing Skin irritation testing Skin sensitization testing Animal injection tolerance testing Inflammatory response observation Accumulation evaluation In vivo degradation testing Drug release performance testing Biodistribution and absorption behavior studies
Applications of PMMA in Aesthetic Formulations and Cosmetics
PMMA is widely used in various high-value sectors, including biomedicine, cosmetics, and medical aesthetics, due to its excellent biocompatibility, transparency, stability, and customizable microsphere structures. The medical-grade, injectable-grade, and cosmetic-grade PMMA products offered by BOC Sciences not only meet clinical safety and functional requirements but can also be tailored to different formulations and usage scenarios through surface modifications, particle size control, and other techniques. The PMMA microspheres and their formulations we customize for clients can be applied in areas such as tissue filling, drug delivery, skincare, anti-aging, concealing, and sensory enhancement. Additionally, we support the development of various dosage forms, such as injectables, gels, creams, powders, and emulsions. With flexible preparation processes and rigorous quality control, BOC Sciences is helping numerous clients integrate PMMA into the development of cutting-edge products, fostering innovation in biomedical and beauty technologies.
Tissue Fillers
PMMA microspheres are widely used in medical aesthetics as injectable fillers, suitable for facial shaping, wrinkle filling, and soft tissue repair, offering long-term stability and excellent biocompatibility.
Drug Controlled Release Carriers
As an efficient microsphere carrier, PMMA can achieve slow drug release, control release rates, improve efficacy, and reduce side effects, making it suitable for local or systemic drug delivery.
Skincare Microspheres
In products such as facial cleansers and exfoliators, PMMA microspheres are used for gentle exfoliation and deep cleaning, enhancing skin feel and improving the skincare experience while causing minimal skin irritation.
Cosmetic Sensory Improvement
In foundation and loose powder products, PMMA microspheres enhance skin feel, improve spreadability and coverage, and provide a soft-focus effect, making the makeup look more natural and long-lasting.
Sunscreen Agent Dispersion Carriers
PMMA microspheres are used to encapsulate and disperse UV absorbers, effectively enhancing the stability of sunscreen ingredients, improving even application, and boosting the protective capabilities and skin compatibility of sunscreen products.
Medical Aesthetic Injectables
PMMA microspheres, used as semi-permanent fillers, are injected into the skin to stimulate collagen production, achieving facial lifting and anti-aging effects that are long-lasting and stable.
Skin Anti-Aging Microsphere System
By carrying antioxidants or peptide-based active ingredients, PMMA microspheres can enable sustained release, effectively combating free radicals and addressing skin aging issues like fine lines and sagging.
Biomedical Imaging Materials
After surface modification, PMMA microspheres can be used as carriers to deliver fluorescent, magnetic, or other labels for in vivo imaging, cell tracing, and disease localization in biomedical research.
FAQs
Is PMMA a copolymer?
PMMA is typically not a copolymer but a homopolymer made from the polymerization of methyl methacrylate (MMA) monomers. However, in practical applications, PMMA can be copolymerized with other monomers, such as acrylonitrile or styrene, to enhance its properties, like toughness or thermal stability, forming modified PMMA materials.
Is PMMA a thermoplastic?
Yes, PMMA is a typical thermoplastic. It softens when heated and re-solidifies when cooled, a process that can be repeated. Its thermoplasticity makes it suitable for processing methods like injection molding, extrusion, and thermoforming, and it is widely used in optical materials, medical devices, and cosmetic products.
Is PMMA acrylic?
Yes, PMMA is one of the most common acrylic polymers, often referred to as "organic glass" or "acrylic." It is a polymer made from the polymerization of methyl methacrylate and is the most stable and widely used in the acrylic family of materials.
Is PMMA hydrophobic or hydrophilic?
PMMA is a hydrophobic material. Its molecular structure lacks polar hydrophilic groups, resulting in low water affinity and adsorption. This characteristic makes it suitable for moisture resistance and water isolation, but its hydrophilicity or bioactivity can be enhanced through surface modification in biomedical applications.
Is PMMA safe?
Under appropriate usage conditions, PMMA is considered a safe material. Its biocompatibility is excellent, and it is widely used in medical implants, dental restorations, injectable fillers, and cosmetics. High-purity PMMA materials are commonly used in human contact applications and have obtained numerous safety certifications and regulatory approvals.
Is PMMA toxic?
PMMA itself is non-toxic, especially when processed into high-purity medical-grade and cosmetic-grade forms, and is widely used in human contact applications. However, its monomer (methyl methacrylate) has irritant properties before polymerization, so it is essential to control residual monomer levels during the manufacturing process.