PCL Filler Development
BOC Sciences is dedicated to providing a one-stop service for polycaprolactone (PCL) filler preparation, formulation optimization, and custom development for clients in the medical aesthetics, cosmetics, and biomedical fields. We cover all stages of product development, from raw material molecular design to pilot-scale process scaling, helping clients quickly realize the market conversion of high-value-added PCL products. Our team has extensive experience and advanced technology, capable of offering customized solutions based on different needs. By continuously optimizing molecular design, preparation processes, and degradation performance control, we strive to provide customers with safer, more effective, and long-lasting PCL filler products.
Advantages of BOC Sciences in PCL Filler Development
Comprehensive Custom Synthesis Platform
We can develop customized PCL fillers according to customer requirements, including different molecular weights, end-group modifications (e.g., hydroxyl, carboxyl, amine groups), copolymer structures (e.g., PCL-PEG, PCL-PLA), and drug/active substance loading designs.
High Purity Raw Materials Assurance
Through a rigorous quality control system, BOC Sciences ensures that raw materials used in PCL filler synthesis have high purity and consistency, making them especially suitable for medical and pharmaceutical applications that require stringent biocompatibility and non-toxicity.
Variety of PCL Derivatives and Modification Services
BOC Sciences offers a range of PCL and copolymer materials, including PCL-g-PEG (enhanced solubility), functionalized PCL for targeted delivery or grafting of active groups, as well as PCL microspheres, nanoparticles, and fibrous scaffolds in various carrier systems.
Highly Controllable Process Development Capability
We possess full-process development capabilities from laboratory to pilot-scale and large-scale production. Whether it's micro-scale drug loading experiments or large-scale synthesis and purification, our development team can provide efficient, reproducible production processes.
cGMP Certified Production Process
BOC Sciences strictly adheres to cGMP standards in the production process, ensuring that every stage from R&D to production meets international quality control requirements. We offer large-scale production support, ensuring the consistency, stability, and safety of each batch of PCL fillers.
Comprehensive Regulatory Filing Assistance
BOC Sciences offers comprehensive technical support to customers, including production process optimization, product registration, and regulatory filing assistance, helping clients smoothly enter the market and quickly achieve product launch.
PCL Filler Development Services by BOC Sciences
With years of experience and technical accumulation, BOC Sciences has a unique advantage in PCL dermal filler development. We offer comprehensive development services from molecular design, microsphere preparation to injection formulation optimization, providing customers with customized PCL filler solutions. By precisely controlling the molecular structure and degradation characteristics of PCL, we can adjust its biocompatibility, injectability, and long-lasting effects, ensuring optimal performance of each filler in vivo. Whether for facial contouring, anti-aging treatments, or tissue repair and drug delivery, BOC Sciences can provide high-performance PCL fillers to help customers enhance product competitiveness.
Multi-Molecular Weight PCL Design and Synthesis
BOC Sciences has an advanced ring-opening polymerization technology platform capable of synthesizing low, medium, and high molecular weight PCL materials to meet different application needs. By precisely controlling polymerization conditions, we can adjust the molecular structure of PCL, such as end-group modification, branching degree optimization, and copolymer modification (e.g., PCL-PEG, PCL-PLA), thereby controlling its hydrophilicity, degradation rate, and mechanical properties.
High-Performance PCL Microsphere Preparation
BOC Sciences has mature technology for preparing highly uniform microspheres, capable of producing PCL microspheres with controllable particle size, concentrated distribution, and good injectability. These microspheres are widely used in medical aesthetics (30–70 μm), cosmetic microcapsules (5–30 μm), and biomedical drug delivery platforms (1–10 μm). We employ emulsion polymerization, spray drying, and solvent evaporation techniques to achieve precise preparation for different particle sizes and functional requirements.
Injection-Formulation PCL Development
For various medical aesthetics and tissue regeneration applications, BOC Sciences has developed a range of injection-type PCL formulations. Based on the synergistic effect between PCL microspheres and biological matrices (such as CMC, HA, PEG), we adjust the product's viscosity, elastic modulus, moldability, and tissue integration ability, developing fillers with excellent injectability, long-lasting effects, and collagen-stimulating properties.
Degradation Performance Regulation
BOC Sciences precisely regulates the degradation cycle of PCL in vivo by controlling its molecular structure, particle size, and the composition of the matrix in the formulation. We cover different treatment cycle requirements ranging from 12 to 36 months. We can also design PCL formulations with collagen generation-promoting capabilities, activating the endogenous repair process in the dermis while achieving volume filling, resulting in both long-lasting anti-aging and structural remodeling effects.
PCL Filler Process Scaling and cGMP Support
BOC Sciences provides full-process support for the development of PCL dermal fillers, covering everything from laboratory research to industrial-scale production. We comprehensively support pilot-scale scaling, process parameter validation, and cGMP-compliant production systems. We have advanced pilot-scale facilities and can quickly transition from gram to kilogram scale according to customer needs, improving production efficiency while ensuring material quality consistency. For critical process parameters during scaling, such as mixing speed, stirring time, and emulsification conditions, we have established a systematic process parameter validation platform to ensure highly consistent physical and chemical properties across different batches. Additionally, BOC Sciences offers various sterilization methods, including gamma radiation sterilization and ethylene oxide sterilization, and evaluates their impact on product performance (e.g., molecular weight, mechanical properties, and biocompatibility) based on the PCL formulation's sensitivity, recommending the optimal sterilization strategy. We also conduct accelerated and real-time stability studies, particularly storage tests at 37 °C for 3–6 months, to assess the long-term stability and degradation behavior of PCL fillers in clinical applications, providing strong technical support for product registration and market launch.
PCL Filler Quality Testing Services
BOC Sciences provides comprehensive PCL filler quality testing and performance evaluation services, covering the entire process from raw material quality to final product analysis. We understand the strict requirements for stability, safety, and biological activity in high-performance aesthetic and biomedical products. Therefore, we have established a professional testing system, including key indicators such as particle size control, mechanical properties, injection smoothness, degradation behavior, and tissue compatibility. Relying on advanced analytical instrumentation and a stringent quality control system, we ensure that each batch of products meets international standards, with traceability and process scaling support. Additionally, BOC Sciences has developed a complete in vitro cell testing platform and in vivo animal evaluation platform, enabling cell viability testing, inflammation factor detection, fibroblast stimulation experiments, tissue compatibility observation, and post-subcutaneous injection reaction assessments. Through multidimensional biological evaluations, we provide scientifically rigorous data support to accelerate product registration and preclinical research processes.
Key Analysis Projects
Particle size distribution Zeta potential Molecular weight and distribution (Mw, Mn, PDI) Melting point and thermal properties (DSC) Degradation rate testing Rheological properties testing Surface morphology observation Chemical structure identification Dissolution performance analysis Cytotoxicity testing
Main Testing Instruments
Laser particle size analyzer (Mastersizer) Dynamic light scattering (DLS) Gel permeation chromatography (GPC) Differential scanning calorimeter (DSC) Scanning electron microscope (SEM) Fourier-transform infrared spectrometer (FTIR) Nuclear magnetic resonance (NMR) Rheometer UV-Vis spectrophotometer Enzyme-linked immunosorbent assay (ELISA)
Applications of PCL Fillers in Aesthetic Medicine and Regenerative Therapies
With the continuous development of regenerative medicine and aesthetic technology, PCL, a biodegradable and highly biocompatible polymer, is gradually becoming an important material in the medical aesthetics, biomedical, and cosmetics industries. Its flexibility, adjustable degradation rate, and excellent injection properties have led to its widespread application in various clinical and topical solutions. BOC Sciences is committed to developing high-performance PCL fillers for clients, supporting a wide range of applications from facial contouring to tissue engineering regeneration, and assisting clients in creating innovative, high-performance, and safe end products. We offer customized formula design and functional optimization based on client needs, driving the deep integration and application of PCL in precise treatments and anti-aging beauty.
Facial Contour Filling
PCL fillers can be used for non-surgical facial contour shaping, such as enhancing the nose bridge, chin, and cheek fullness. With strong support, excellent injectability, and long-lasting effects, PCL fillers stimulate collagen production, achieving both immediate shaping and long-term anti-aging benefits, meeting the needs of personalized aesthetic medicine.
Deep Anti-Aging Treatment
When PCL microparticles are injected into the skin's dermal layer, they stimulate fibroblast activity and induce continuous collagen production, effectively improving signs of aging such as skin laxity and fine lines. Compared to traditional hyaluronic acid fillers , PCL has a longer duration and more natural repair effects, making it widely used in deep anti-aging treatment plans.
Biodegradable Injectable Scaffolds
PCL, as an injectable scaffold material, is widely used in soft tissue and cartilage repair engineering. Its biodegradable structure provides a good environment for cell adhesion and proliferation, supporting tissue regeneration processes. BOC Sciences can adjust the morphology and degradation performance of PCL according to specific needs, helping to create efficient and safe tissue engineering products.
Drug Sustained Release Microsphere Carriers
Due to its hydrophobic and adjustable degradation characteristics, PCL is often used to develop sustained-release microsphere systems for continuous drug release in local tissues. It is suitable for treatments of skin diseases, local pain relief, and anti-inflammatory drug release, significantly improving therapeutic effects and patient compliance while reducing drug frequency and systemic side effects.
Ocular Rejuvenation
By injecting low-concentration, fine-particle PCL to fill tear troughs, dark circles, and under-eye hollows, a gentle transition is achieved with no risk of edema or nodules, providing natural repair while gradually improving collagen loss in the eye area.
Cosmetic Active Ingredient Carriers
In high-end cosmetics, PCL is also used to develop controlled-release microspheres or nanoparticles for encapsulating active ingredients like vitamins and peptides, enhancing the longevity and penetration of the product's effects.
Tissue Repair Aids
After plastic surgery or wound repair, PCL fillers can serve as temporary filling materials to support and repair, helping soft tissues restore volume and contour, improving post-surgical depressions or unevenness.
Regenerative Medicine Stem Cell Carriers
PCL, as a cell carrier scaffold, is suitable for carrying mesenchymal stem cells for local injection transplantation, with potential applications in skin regeneration, joint repair, muscle regeneration, and other emerging therapies.
FAQs
What is a PCL filler?
PCL fillers are injectable aesthetic materials based on polycaprolactone (PCL), a biodegradable medical polymer. This material has good biocompatibility and controllable degradation properties. Once injected into the skin, it acts as a supportive filler to maintain tissue volume while stimulating collagen regeneration, achieving natural and long-lasting shaping and anti-aging effects. PCL fillers are commonly used for facial contour adjustment, deep anti-aging treatments, and soft tissue repair, offering strong support, long-lasting effects, and high safety.
How long does PCL filler last?
Due to its unique molecular structure and degradation properties, PCL fillers have a significantly longer duration compared to common hyaluronic acid fillers. Typically, PCL fillers last 2 to 4 years, with variation depending on product concentration, injection site, and individual metabolism. While filling, PCL continuously stimulates collagen production, so even as the polymer gradually degrades, the tissue support remains for some time. Therefore, PCL fillers are considered a high-quality material that combines immediate filling and long-term anti-aging effects.
Is PCL filler the same as HA filler?
PCL fillers differ significantly from hyaluronic acid (HA) fillers in composition, mechanism of action, and duration. HA fillers primarily achieve immediate filling through water absorption, with natural effects but relatively short duration, typically lasting 6 months to 1 year. PCL fillers, as a biodegradable polymer, act through both physical support and collagen regeneration mechanisms, providing longer-lasting effects, usually 2 to 4 years. Additionally, HA can be reversed by hyaluronidase, whereas PCL is irreversible but has a predictable metabolic process, making it more suitable for long-term shaping treatments.
What is PCL under-eye filler?
PCL under-eye fillers are polycaprolactone-based injectable products designed specifically for the eye area, mainly used to improve signs of aging such as tear trough hollows, dark circles, and under-eye sagging. Compared to traditional hyaluronic acid, PCL fillers not only provide soft and natural support but also stimulate continuous collagen generation, fundamentally improving the skin structure and enhancing the tightness of the eye area.