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BOC Sciences has complete toxicokinetics, analysis and research facilities and equipment, and can apply a variety of analysis methods to provide customers with high-quality and comprehensive analysis and testing.


With the deepening of new drug research, many candidate compounds (including small molecules and macromolecules) were eliminated during the research and development process due to safety issues. Therefore, only after a sufficient preclinical safety evaluation of the new compound, it is possible to consider whether the drug can enter the clinical trial.

Toxicokinetics is one of the important research contents of drug toxicology research, and some pharmacokinetic data can be obtained. Its research focuses on interpreting toxicity test results and predicting human safety. The purpose of toxicokinetics is to study the relationship between the concentration or dose of a compound and its potential toxicity. BOC Sciences has experience with all types of toxicity studies, as well as expertise in the design of complex nonclinical studies.

Toxicokinetic Analysis

In toxicokinetic analysis, the concentration of the test substance that produces toxic effects can be determined. We use advanced pharmacokinetic software to calculate toxicokinetic parameters to determine peak drug concentration (Cmax), time to peak (Tmax), terminal elimination half-life (T1/2) and area under the drug-time curve (AUC), Primarily used to assess dose proportionality, sex differences, and degree of accumulation.

Our Advantages

  • One-stop technical service
  • Customized exclusive solutions for customer needs
  • Well-proven kinetics software
  • Rich experience in toxicokinetic analysis and research
  • Applicable to a wide range of therapeutic areas
  • Complete bioanalysis facilities

Service Scope

  • In Vitro Metabolism Studies
    • Metabolic stability (liver microsomes, S9, Cytosol, hepatocytes, blood)
    • Metabolite research
    • Plasma protein binding assay
    • Cytochrome P450 enzyme inhibition or induction
    • Transporter substrate and inhibition evaluation
    • Phenotype identification of cytochrome P450 enzymes
    • Interspecies comparison
  • In Vivo DMPK Studies
    • Animal administration (oral/intravenous)
    • Biological sample collection
    • Biological sample testing
    • Data fitting analysis
  • In Vivo TK Studies
    • TK/PD/TOX analysis
    • Dose-relationship/gender difference/accumulation analysis
    • Active ingredient/prodrug/metabolite monitoring
    • Immunogenicity analysis
  • Analytical Method Development and Validation
    • Method specificity
    • Precision, accuracy
    • Sensitivity, stability
    • Standard curve and linear range
    • Extraction recovery

Service Process

  1. Fill in the application form
  2. Communicate with BOC Sciences to confirm the testing standards
  3. Sign the contract
  4. Send samples
  5. Sample testing
  6. Issue a test report

Detection Methods

  • HPLC
  • LC-MS / MS
  • Online SPE – LC-MS / MS
  • EIA
  • RT-PCR

BOC Sciences uses mathematical models to analyze and study the kinetics of absorption, distribution, metabolism and elimination (ADME) of exogenous chemical substances in the body by measuring toxicokinetic parameters (such as AUC, Cmax, Tmax, etc.), revealing Relationship between target organ exposure dose and exposure time and mechanism of action. The analysis results provide a basis for further other toxicity tests, and provide a basis for clinical medication and the diagnosis and treatment of drug overdose.