Polynucleotide Formulation Development
BOC Sciences is dedicated to providing comprehensive services for the development of polynucleotide (PN) formulations. We have an experienced R&D team capable of offering personalized solutions at every stage, from initial formulation design to final production scale-up. Our services cover all key aspects of polynucleotide formulation, ensuring high-quality and reliable PN formulations that support more effective drug delivery solutions, enabling breakthroughs in research and production.
What is a Polynucleotide?
Polynucleotides (PN) are short-chain nucleotide derivatives extracted from salmon sperm DNA, which undergo secondary refinement to achieve a larger molecular weight and more complex structure. Compared to PDRN, PN offers more lasting regenerative effects and provides stronger support during skin regeneration. PN's benefits include promoting the regeneration of collagen, non-collagen proteins, and elastin, significantly improving fine lines, skin laxity, and enlarged pores, while restoring firmness and elasticity to the skin. PN also possesses strong water-locking and moisturizing abilities, helping to consolidate water molecules and enhance skin hydration, balancing sebum secretion, and improving skin texture, making the skin smoother and more radiant. Additionally, as a macromolecule, PN slowly releases PDRN during the skin regeneration process, offering anti-inflammatory and soothing effects, repairing the skin barrier, and is ideal for long-term anti-aging and skin firming needs.
Advantages of BOC Sciences in Polynucleotide Formulation Development
Innovative Formulation Design Capabilities
We provide personalized PN formulation designs tailored to customer needs, ensuring optimal drug efficacy and stability.
Optimized Delivery Systems
Precise design of PN delivery carriers to improve bioavailability and targeted delivery, maximizing therapeutic efficacy.
Strong Production Scale-Up Capabilities
From laboratory scale to GMP large-scale production, we ensure that every production step meets strict quality standards, supporting mass production needs.
Advanced Equipment and Technology
Using leading-edge equipment and technology for formulation development and production to ensure formulation stability and superior therapeutic outcomes.
Efficient Quality Control
Through stringent quality testing protocols, we ensure the consistency and reliability of each batch of polynucleotide formulations.
Professional Interdisciplinary Team
A team of experts from fields such as biology, chemistry, and pharmacy provides comprehensive technical support and solutions.
Customer-Customized Services
We tailor formulation development to meet the specific requirements of customers, ensuring compliance with professional standards and application needs across different fields.
Wide Range of Applications
Our PN formulations are applicable in gene therapy, vaccine development, anti-tumor therapy, and other biopharmaceutical fields, with a broad application scope.
Polynucleotide Formulation Development Services by BOC Sciences
BOC Sciences offers a full range of PN formulation development services, committed to providing customers with efficient, safe, and innovative solutions. Our services cover every stage from initial formulation design to final production scale-up, ensuring strict control over technology and quality at each phase. Whether it is new drug development or optimization of existing products, we offer customized services to help clients achieve breakthroughs and drive advancements in drug and treatment technologies.
Formulation Design
We design suitable formulations based on the properties and target applications of polynucleotides, including the type of target polynucleotide, delivery methods, and stability requirements, followed by small-scale laboratory validation.
Formulation Optimization
Based on the preliminary formulation design, we optimize the formulation through multiple experiments and data analysis, conducting stability studies to enhance drug efficacy, release speed, and biocompatibility.
Delivery Carrier Design
We design innovative delivery carriers, such as liposomes, nanoparticles, and polymers, to optimize the delivery efficiency and targeting of polynucleotides, ensuring precise targeting and enhanced therapeutic effects.
Scale-Up and Production
We provide complete scale-up services from laboratory scale to GMP large-scale production, ensuring that production processes meet quality standards and maintaining consistency for large-scale manufacturing.
Polynucleotide Formulation Types Provided by BOC Sciences
BOC Sciences provides comprehensive formulation development services, focusing on the customized design of various PN formulations. Our technical team has rich experience and can develop formulations for different applications, including oral, injectable, and topical products, based on customer needs. We supply high-quality active ingredients for PN formulations and select appropriate stabilizers, solvents, emulsifiers, fillers, and sustained-release components based on the formulation type. Additionally, we specialize in the design of sustained-release formulations, using polymers and other sustained-release components to control the release rate of PNs, thereby improving the persistence of therapeutic efficacy.
Injectable Formulations
We provide stable, injectable polynucleotide formulations that ensure efficient and safe drug delivery through injection, offering precise solutions for different diseases and treatment needs.
Mesotherapy Formulations
For skin repair and regeneration treatments, we design polynucleotide mesotherapy formulations that promote skin repair, enhance skin elasticity, and effectively combat aging.
Rejuran Healer Formulations
Specifically designed for skin regeneration and repair, the Rejuran Healer formulation is rich in polynucleotides, stimulating skin cell self-repair, significantly enhancing skin texture and luster, and slowing the aging process.
Ophthalmic Formulations
We have designed specialized ophthalmic formulations to ensure the precise delivery of polynucleotides in the eye area, improving vision health and relieving eye discomfort.
Dressing Formulations
The application of polynucleotides in wound dressings accelerates the healing process, promotes cell regeneration, and provides excellent anti-inflammatory effects, ensuring quick recovery for patients.
Facial Cream Formulations
We offer facial creams containing polynucleotides, which improve skin barrier function, enhance anti-aging abilities, and provide long-lasting moisturizing effects.
Serum Formulations
For skin repair and anti-aging effects, we provide serum formulations containing polynucleotides to enhance skin elasticity and smoothness, deeply nourishing and repairing damaged skin.
Spray Formulations
Our polynucleotide spray formulations have strong moisturizing, soothing, and anti-inflammatory effects, suitable for daily skin care and instant hydration, promoting skin health.
Active Ingredient Blending Services for Polynucleotide Formulations
The blending of active ingredients is crucial in the development of PN formulations, significantly enhancing the therapeutic effect and stability of the formulations. With its extensive research experience and technological expertise, BOC Sciences offers customized active ingredient blending services. By scientifically and rationally selecting and combining different active ingredients, we are able to provide more efficient and innovative formulation solutions to our clients. Our blending services not only optimize the therapeutic effects of PN but also enhance the biocompatibility and targeting properties of the formulations, ensuring they achieve the desired therapeutic outcomes.
Vitamin C Vitamin E Retinol Hyaluronic Acid Peptides Plant Extracts Phospholipids Glycerin α-Arbutin Ceramides Resveratrol Niacinamide
GMP Scale-up Manufacturing Capability for Polynucleotide Formulations
BOC Sciences possesses strong technical capabilities and advanced facilities in GMP scale-up manufacturing of PN formulations, offering an integrated solution from laboratory R&D to large-scale production for global clients. With GMP-certified production facilities, we ensure that every batch of PN formulations meets stringent quality standards while being efficiently and stably produced at scale. Our manufacturing processes cover the production needs of various PN formulations, offering flexible custom services from small-scale experimental stages to large-scale commercial production. The facilities are equipped with advanced automated production lines and efficient quality control systems, greatly improving production efficiency, reducing human error risks, and ensuring product consistency and high quality. Furthermore, our production environment strictly follows international standards, with clean rooms and environmental control systems to ensure the products remain uncontaminated during production and storage, guaranteeing purity and stability.
Quality Testing Services for Polynucleotide Formulations by BOC Sciences
BOC Sciences is committed to providing comprehensive, professional quality testing services for PN formulations to ensure that each batch meets the highest quality standards during production and usage. We employ advanced analytical techniques and testing equipment covering all stages from raw materials to finished products, evaluating the purity, stability, safety, and potency of PN formulations. Our quality testing services not only comply with international GMP standards but also offer personalized testing plans based on client needs, ensuring that products meet the regulatory requirements of different markets. With years of industry experience and strong technical capabilities, BOC Sciences provides reliable and efficient quality assurance.
Testing Instruments
High-Performance Liquid Chromatography (HPLC) Mass Spectrometry (MS) Gel Permeation Chromatography (GPC) Accelerated Stability Testing Equipment Laser Diffraction Particle Size Analyzer (Malvern Mastersizer) pH Meter Karl Fischer Titration Sterility Testing Equipment Atomic Absorption Spectroscopy (AAS) Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Analytical Projects
Purity Analysis Molecular Weight Determination Stability Testing Dissolution Testing Particle Size Distribution Analysis pH Measurement Moisture Content Testing Sterility Testing Heavy Metals and Harmful Substance Testing Content Uniformity Analysis
Applications of Polynucleotides in Skincare and Aesthetic Treatments
The research and application of PN formulations in the medical aesthetics and skincare fields continue to expand, becoming essential tools for improving skin health, anti-aging, and treating various skin issues. Due to their excellent biocompatibility, cell repair ability, and antioxidant properties, PN formulations have immense potential in the medical aesthetics industry. Through continuous research and development, BOC Sciences offers innovative PN formulation solutions to help develop more effective skincare products that meet the growing market demand.
Skin Enhancers
PN formulations serve as skin enhancers, deeply stimulating collagen and elastin production, effectively improving skin firmness and elasticity, and addressing skin sagging in individuals at the early stages of skin aging.
Anti-Aging Creams
Anti-aging creams with added PN can provide lasting nourishment to the skin, promote skin regeneration, and slow down aging signs such as fine lines and wrinkles. They are suitable for mildly mature and mature skin.
Mesotherapy Injections
PN mesotherapy injections quickly penetrate the skin, activate cell regeneration, and improve skin elasticity by promoting collagen synthesis. These are commonly used for anti-aging and skin tightening treatments.
Facial Serums
PN, as a key ingredient in facial serums, has potent moisturizing and reparative effects, deeply hydrating the skin, and improving issues such as fine lines, uneven skin tone, and dryness.
Sensitive Skin Repair Creams
PN formulations have significant anti-inflammatory and soothing effects, making them ideal for sensitive skin repair creams, helping to relieve inflammation, reduce redness, and restore skin barrier function.
Deep Moisturizing Masks
Adding PN to deep moisturizing masks enhances skin hydration and promotes skin repair, improving dry skin and fine lines, making the skin smoother and more hydrated.
Acne Repair Serums
PN can be an important ingredient in acne repair serums, leveraging its anti-inflammatory properties to reduce acne inflammation, promote wound healing, and help minimize acne scarring.
Eye Serums
PN eye serums have anti-aging effects and can effectively reduce fine lines and puffiness around the eyes, helping restore firmness and elasticity, alleviating skin aging issues around the eyes.
FAQs
How are polynucleotides formed?
Polynucleotides are long-chain molecules formed by the linkage of multiple nucleotides through phosphodiester bonds. Each nucleotide consists of three parts: a nitrogenous base, a five-carbon sugar (usually ribose or deoxyribose), and a phosphate group. During the synthesis of DNA or RNA, nucleotides are sequentially linked through phosphodiester bonds, forming a chain structure. The length and composition of the polynucleotide chain vary based on its function and application requirements, and it is typically synthesized in cells by polymerases through specific catalytic processes.
How do polynucleotides work?
Polynucleotides interact with molecules inside and outside of cells through their long-chain structure, performing various biological functions. For example, in DNA and RNA, the polynucleotide chains convey genetic information, determining the sequence of protein synthesis. In medical aesthetics, as skin repair and anti-aging ingredients, PN formulations promote collagen and elastin synthesis, repairing damaged skin and enhancing the skin barrier function. The action of polynucleotides is based on their biological activity, which can activate cell regeneration and repair processes.
How long do polynucleotides last?
The longevity of polynucleotides depends on their specific application and form. In the medical aesthetics field, products like PN mesotherapy injections typically show effects that last 6-12 months. Over time, the effects gradually diminish, so regular treatments are required to maintain the results. The durability of PN also depends on individual skin conditions, treatment frequency, and environmental factors. Generally, PN continuously stimulates skin regeneration and collagen synthesis, improving skin condition for an extended period, but ongoing maintenance and usage are necessary to sustain optimal results.