PDRN Filler Development
BOC Sciences delivers superior PDRN dermal filler development services for clients. Our PDRN dermal filler support services achieve superior skin repair and anti-aging outcomes through advanced biotechnology, paired with innovative formulation optimization techniques, alongside GMP-certified production capabilities. Our expert team combines solid scientific research expertise with industry knowledge to provide tailored solutions that address the unique demands of various markets and consumers worldwide.
What is PDRN in Skincare?
Polydeoxyribonucleotide (PDRN) is a deoxyribonucleic acid (DNA) compound derived from the semen DNA of salmon, trout, or sturgeon, extracted through a strict purification process. It has high safety and stability. The outstanding cell repair and regeneration properties of PDRN make it the preferred choice for dermal fillers in skin regeneration and anti-aging treatments. PDRN dermal fillers support skin tissue repair while stimulating skin cell metabolism to improve skin elasticity and firmness and decelerate the aging process. The stimulation of skin cell self-repair mechanisms boosts collagen production while enhancing skin hydration, which results in smoother and more radiant skin. Currently, PDRN dermal fillers serve as a common treatment in medical aesthetics to address conditions like skin laxity, wrinkles, and pigmentation along with signs of aging.
Advantages of BOC Sciences in PDRN Filler Development
High-Purity PDRN Raw Material Supply
We provide high-purity PDRN raw materials, ensuring stable, contamination-free quality through strict selection and advanced purification, meeting global standards.
Advanced Formulation R&D Capabilities
We optimize PDRN dermal filler formulations by controlling concentration, pH, permeability, and biocompatibility for superior rheological properties, tissue integration, and durability.
Innovative Blending Technology
We blend PDRN with active ingredients like peptides, hyaluronic acid, and amino acids to enhance skin repair, anti-aging, and moisturizing effects.
cGMP-Grade Production Capabilities
Our cGMP-compliant facilities ensure global-standard production, from raw material processing to sterile formulation and final packaging.
Rigorous Quality Control System
We use HPLC, GC, and MS to test PDRN for purity, molecular weight, degradation products, and biocompatibility.
Comprehensive Stability Studies
Accelerated aging and temperature/humidity tests ensure long-term stability of PDRN dermal fillers.
Personalized Customization Services
We offer flexible customization, including formulation design, ingredient combinations, viscoelasticity regulation, and sustained-release development.
Authoritative Preclinical Testing Services
We provide in vitro and in vivo testing for cell proliferation, skin repair, anti-inflammatory, and antioxidant assessments to validate PDRN filler efficacy and safety.
PDRN Dermal Filler Development Technology
BOC Sciences has deep technical expertise and extensive industry experience in PDRN dermal filler development, dedicated to providing comprehensive solutions ranging from raw material selection, formulation design, and formulation optimization to blending technology. Leveraging advanced biomaterial technologies combined with intelligent delivery systems, we ensure efficient absorption and long-lasting effects of PDRN in skin tissues. Below are our core technological capabilities in PDRN dermal filler development:
PDRN Raw Material Selection
We use high-purity PDRN raw materials to ensure nucleotide chain integrity and biological activity. Through a strict quality control process, we select PDRN with appropriate molecular weight and controllable degradation rates to meet different product requirements.
Filler Formulation Design
PDRN itself usually needs to be combined with other ingredients, such as hyaluronic acid, glycerin, amino acids, etc., to prepare injectable facial fillers. Based on application requirements, we develop various PDRN formulations, including injectable fillers and injectable gels.
Formulation Optimization
By reasonably controlling PDRN concentration, pH, and excipient ratios, we optimize product stability and biocompatibility, ensuring good tissue integration and repair effects while minimizing the risk of inflammation.
Blending Technology
We carefully design PDRN blending schemes with various active ingredients, such as hyaluronic acid, peptides, collagen, and complex amino acids, to achieve synergistic effects and enhance skin regeneration, anti-aging, and hydration.
Sustained-Release System Development
We use advanced sustained-release technologies, such as nanocarriers, microsphere encapsulation, and liposome encapsulation, to control the release rate of PDRN, prolong its action time in skin tissues, making the filler products more durable and effective.
Formulation Strategy of PDRN Fillers with Active Ingredients
As mentioned above, to enhance the repair, anti-aging, and moisturizing effects of PDRN dermal fillers, BOC Sciences adopts scientific blending strategies to combine PDRN with various high-efficiency active ingredients, creating synergistic effects to optimize product efficacy and clinical performance. These ingredients have significant effects in cell repair, antioxidant activity, moisturizing, whitening, and anti-inflammatory properties. By precisely controlling the formula ratio and stability, BOC Sciences ensures that PDRN dermal fillers deliver outstanding performance in different application scenarios, offering clients high-end medical aesthetic solutions. The bioactive ingredients we support include, but are not limited to:
Peptides Glutathione Sodium Hyaluronate Collagen Complex Amino Acids Niacinamide Tranexamic Acid Coenzyme Q10 Adenosine Licorice Root Extract Retinol Ceramides Centella Asiatica Extract Caffeine Beta-Glucan
GMP Manufacturing Capability for PDRN Dermal Fillers
BOC Sciences possesses production facilities that meet global cGMP standards, providing robust support for the scaled manufacturing of PDRN dermal fillers. Our production bases are equipped with sterile production lines, high-precision ingredient systems, automated filling equipment, and advanced sterile filtration technology to ensure the product's high purity, stability, and safety. We implement stringent environmental control measures, including constant temperature and humidity regulation, HEPA filtration systems, and cleanroom classification management, ensuring that the production process complies with the highest sterile requirements. Additionally, we have large-scale batch production capabilities, allowing us to quickly respond to market demands and provide end-to-end services, from small-scale trials to commercial production.
Quality Testing for PDRN Dermal Fillers
In the development and production process of PDRN dermal fillers, quality is key to ensuring both effectiveness and safety. BOC Sciences understands this well and, with years of experience and technical accumulation, provides comprehensive quality testing services to ensure each batch of products meets international pharmaceutical and cosmetic safety standards. We use internationally advanced testing technologies and professional testing instruments to perform stringent quality control on each batch of PDRN products, ensuring their stability and effectiveness in various storage and usage environments. Our testing services cover every stage from raw material inspection to final product release, strictly controlling every detail to ensure products meet customer requirements and providing precise quality reports. Below are the main quality testing services we offer and the high-precision testing instruments we use:
Testing Instruments and Equipment
High-Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) Mass Spectrometry (MS) UV-Vis Spectrophotometer Gel Permeation Chromatography (GPC) Atomic Force Microscope (AFM) Dynamic Light Scattering (DLS) Atomic Absorption Spectrometer (AAS) Fourier-Transform Infrared Spectrometer (FTIR)
Quality Testing Services
Purity Testing Component Content Determination Heavy Metal Testing Microbial Testing Sterility Testing Endotoxin Testing pH Testing Osmotic Pressure Testing Stability Studies
In Vitro and In Vivo Testing for PDRN Dermal Fillers
BOC Sciences offers systematic in vitro and in vivo testing services to comprehensively assess the safety, stability, and biological performance of PDRN dermal fillers. Utilizing advanced cell and animal models, combined with various high-throughput analysis techniques, we ensure the product undergoes rigorous validation before entering the market, meeting global regulatory standards. Our integrated evaluation system ensures the safety, efficacy, and stability of PDRN dermal fillers in clinical applications, providing strong scientific support for the development and market entry of high-end aesthetic products.
In Vitro Testing
Cell proliferation and activity testing Cytotoxicity analysis Wound healing experiments Antioxidant capacity testing Inflammatory factor analysis
In Vivo Testing
Subcutaneous filling tests (animal models) Tissue repair and regeneration experiments Acute and chronic toxicity studies Biodegradation and persistence evaluation Immunogenicity analysis
PDRN Applications in Skin Regeneration and Aesthetics
With the continuous development of regenerative medicine and aesthetic technology, PDRN has become an essential active ingredient in high-end aesthetic products due to its outstanding tissue repair, cell regeneration, and anti-aging properties. PDRN can promote fibroblast proliferation, stimulate collagen synthesis, and enhance skin barrier function to achieve deep repair and rejuvenation effects. With its highly effective biological activity, PDRN is widely used in various aesthetic and skincare products, including skin fillers, serums, skin booster solutions, post-procedure recovery creams, eye care products, scalp repair serums, collagen masks, and anti-inflammatory repair sprays. These products can not only improve issues like skin sagging, fine lines, dullness, and inflammation, but also play a significant role in post-surgery recovery and scalp care. BOC Sciences leverages advanced PDRN research and development technology and customized services to provide the aesthetic industry with high-quality PDRN raw materials and formulation solutions, helping clients develop safe and effective regenerative care products.
Dermal Fillers
PDRN is used in high-end hyaluronic acid filler formulations to enhance skin elasticity, improve fine lines, and provide longer-lasting filling effects. It is suitable for microcosmetic injection products like nasolabial folds, chin shaping, and apple cheek lifts.
Anti-aging Serums
PDRN-rich serums promote collagen synthesis, helping skin restore a youthful state. Particularly suitable for high-end firming repair serums, it can be used for facial, neck, and hand care to reduce wrinkles and repair sun-damaged skin.
Skin Booster Injections
PDRN is widely used in skin booster products, combined with hyaluronic acid and peptides, to deeply nourish the skin, enhance hydration, and stimulate skin regeneration. It is suitable for deep repair treatments of dry, rough, and dull skin.
Post-procedure Recovery Creams
Recovery creams with PDRN can be used after laser treatments, microneedling, mesotherapy, and chemical peels to repair the skin, reduce redness, accelerate barrier recovery, and improve skin tolerance, helping skin return to a healthy state faster.
Eye Repair Products
PDRN can be used in eye creams and eye patches to promote cell turnover around the eyes, reducing dark circles, puffiness, and fine lines, making the eye area firmer and younger. It is particularly suitable for high-end anti-aging eye care products.
Scalp Treatment Serums
PDRN is applied in scalp care products to activate hair follicle cells, enhance scalp barrier function, and improve hair loss problems. It is suitable for medical-grade scalp care projects like scalp injection treatments and hair growth serums.
Collagen Regeneration Masks
Biocellulose or hydrogel masks containing PDRN can deeply penetrate the skin, promoting skin repair and cell turnover. These are commonly used for post-procedure recovery, especially suitable for sensitive skin, rosacea, and sun damage repair.
Soothing & Repairing Sprays
Repair sprays with PDRN formulations can be used for sunburn relief, sensitive skin soothing, and post-procedure care, alleviating skin inflammation and repairing damaged barriers. They are suitable for medical aesthetics institutions and high-end skincare brands' repair sprays.
FAQs
Is PDRN a filler?
PDRN itself is not a traditional filler. It is a DNA fragment extracted from fish or other biological sources, primarily used to promote skin repair and regeneration. The main effect of PDRN is to improve the skin's self-repair ability by stimulating metabolism, enhancing blood circulation, and promoting collagen generation, improving the structure and elasticity of the skin. While it is commonly used alongside fillers in skin treatments and aesthetics, PDRN mainly works by enhancing the skin's natural repair capacity rather than directly adding volume like traditional fillers.
Does PDRN really work?
The effectiveness of PDRN has been confirmed in several studies, particularly in promoting skin repair and improving skin health. PDRN can stimulate skin cell regeneration, enhance collagen and elastin production, improve blood circulation, and enhance skin firmness and radiance. Multiple clinical trials have shown that PDRN significantly combats aging, slows down skin sagging, and improves skin texture. As a result, PDRN is widely used in skin regeneration, wound healing, and anti-aging treatments, demonstrating excellent results.
How long does PDRN last?
The duration of PDRN's effects varies depending on individual skin type, treatment area, and frequency of use. Typically, the effects of PDRN injections may last around 6 to 12 months. PDRN works by enhancing the skin's self-repair and collagen production, improving its structure and elasticity. To maintain the effect, regular treatments may be required. However, as everyone's skin response and metabolism differ, the duration may vary. It is recommended to follow professional medical advice for treatment and follow-up.