PLA Filler Development
Injectable polylactic acid (PLA) dermal fillers are biodegradable materials that primarily work by stimulating the body to produce type I and III collagen, improving wrinkles and skin laxity. Represented by poly-L-lactic acid (PLLA) and poly-D,L-lactic acid (PDLLA), they are commonly used for facial wrinkle removal and body contouring, offering excellent biocompatibility and providing results lasting 18–25 months. As a technological pioneer in the field of medical aesthetics materials, BOC Sciences leverages its advanced synthesis platform and extensive material engineering expertise to offer one-stop customized development and large-scale production services for PLA dermal fillers (mainly PLLA and PDLLA), helping clients accelerate product launch and optimize cosmetic effects.
Advantages of BOC Sciences in PLA Filler Development
High Purity Monomer Control
Strict selection of high-purity L-lactic acid and D,L-lactic acid raw materials, combined with dehydration and impurity removal processes, significantly enhances polymerization efficiency and the stability, purity, and biological safety of the final polylactic acid.
Molecular Weight Controllable Polymerization Technology
By employing a precision temperature control system and a combination of metal/organic catalysts, we achieve customized molecular weights ranging from 50,000 to 300,000 Daltons, meeting different degradation cycle and mechanical performance requirements.
Uniform Microsphere Formation Process
Using microfluidics, spray drying, and membrane emulsification technologies, we precisely control the PLA microsphere particle size to range between 10-50 μm, producing injection-grade microsphere formulations with narrow distribution and uniform morphology.
Custom Copolymer Regulation
We can adjust the ratio of PLLA to PDLLA according to customer needs, optimizing the polymer's crystallinity, degradation rate, and collagen-inducing ability, giving the product differentiated competitive advantages.
GMP-Level Production Environment
BOC Sciences has GMP production workshops with cleanroom levels up to Class C/Class A, supporting small-scale, pilot-scale, and large-scale production of injectable raw materials and final formulations, ensuring product quality and regulatory compliance.
Advanced Analytical Platform Support
Equipped with advanced instruments such as GPC, NMR, DSC, and SEM, BOC Sciences fully supports the analysis of PLA materials' structure, thermal properties, particle size, and degradation behavior, ensuring precise and efficient quality control.
PLA Dermal Filler Development Services
BOC Sciences relies on its advanced polymerization technology platform and years of materials engineering experience to provide integrated PLA dermal filler development solutions, ranging from raw material screening to final formulation for biomedical, cosmetics, and medical aesthetics industry clients. We not only focus on the molecular structure and performance regulation of polymers but also emphasize the biocompatibility, injectability, and collagen regeneration stimulation capabilities of the products. Whether PLLA or PDLLA, BOC Sciences can provide accurate customized services, from laboratory small-scale trials to GMP-standard production, meeting various product development and industrialization needs.
PLA Monomer Screening and Purification
We strictly select high-purity L-lactic acid and D,L-lactic acid monomers, using precision distillation and chromatography purification technologies to ensure high conversion rates in polymerization reactions and the biological safety of the final products.
Polymerization Reaction Parameter Optimization
Based on target molecular weight and degradation cycle requirements, we customize critical parameters such as reaction temperature, catalyst type, and polymerization time, achieving control and repeatability of polylactic acid structures.
Particle Size Control and Spherization Technology
Utilizing spray drying, emulsion polymerization, and microfluidic systems, we control PLA microsphere particle size to achieve precise distribution and uniform morphology, meeting the clinical requirements for injection-grade microspheres.
Blending System Design
By blending PLA with functional excipients such as hyaluronic acid, PEG, and glycerol, we enhance the filler's flowability, smooth injection feel, and skin affinity, improving the overall user experience.
Degradation Performance Regulation
By adjusting the ratio and crystallinity of PDLLA and PLLA, we design degradation cycles ranging from 2 to 12 months, accommodating different cosmetic treatment courses and soft tissue repair cycles for clinical needs.
Product Stability Research
Accelerated and long-term stability tests are conducted under ICH guidelines to evaluate the effects of temperature and humidity on product performance, providing scientific guidance for packaging design and storage solutions.
Preclinical Process Scale-Up
We establish standardized processes for scaling from gram-level laboratory synthesis to kilogram-level production, meeting the needs of pilot research, animal experiments, and registration batch samples.
Regulatory Registration Support Services
We provide complete material data packages, including raw material components, impurity analysis, safety evaluations, and biocompatibility reports, to assist clients in completing registration processes in China, the U.S., and Europe.
GMP-Grade Manufacturing Capabilities of PLA Filler
BOC Sciences possesses comprehensive GMP-grade PLA filler production capabilities, focusing on meeting the stringent requirements for high quality, safety, and consistency in the medical aesthetics and biopharmaceutical fields. Our GMP manufacturing facilities are equipped with advanced reaction control systems, cleanroom environments, and quality traceability systems to ensure that each batch meets international quality standards. We have extensive experience in the polymerization processes of PLA and its isomers such as PLLA and PDLLA, as well as in microsphere preparation, purification, and drying techniques. Customization of particle size, degradation rate, and purity is available to meet specific client requirements. BOC Sciences strictly adheres to ICH, USP, and ISO standards, and provides comprehensive analytical and testing capabilities, including microbial control, impurity limits, particle size distribution, and biocompatibility verification, ensuring our products are suitable for direct subcutaneous injection applications. We also support production from small-scale trials to large-scale cGMP manufacturing, fulfilling various needs from preclinical research to commercial stages.
Quality Testing Services for PLA Dermal Fillers
BOC Sciences places great importance on the quality control and structural analysis of PLA dermal fillers. With a comprehensive analysis platform and a professional team, we have established a multi-dimensional testing system covering physical, chemical, thermal, and biocompatibility aspects. We employ internationally advanced analytical instruments and standard methods to ensure comprehensive characterization of the product in terms of molecular structure, particle size distribution, degradation behavior, and impurity residue. This provides our customers with a complete quality data package that meets the regulatory requirements of the biomedical and medical aesthetics fields. BOC Sciences' analysis services support the entire project development cycle, from R&D verification, preclinical research to regulatory submission.
Analysis Projects
Molecular Weight and Distribution Chemical Structure Identification Impurity Residue Analysis Thermal Stability Testing Microsphere Particle Size and Distribution Surface Morphology Observation pH and Viscosity Measurement Degradation Behavior Study Biocompatibility Evaluation Microbial Contamination Testing
Analysis Instruments
Gel Permeation Chromatography (GPC) Nuclear Magnetic Resonance Spectrometer (NMR) Gas Chromatography-Mass Spectrometry (GC-MS) Differential Scanning Calorimeter/Thermogravimetric Analyzer (DSC/TGA) Laser Particle Size Analyzer Scanning Electron Microscope (SEM) Automatic Titrator, Rotational Viscometer Simulated Body Fluid Degradation Experiment System Cell Culture and MTT Testing System Endotoxin Testing Device
Applications of PLA Dermal Fillers
PLA, as a biodegradable and highly biocompatible polymer material, is widely used in fields such as medical aesthetics, cosmetics, and biomedicine. Its application in dermal fillers is particularly prominent, enabling facial sculpting, tissue repair, and collagen regeneration through injection. The PLLA and PDLLA fillers developed by BOC Sciences feature controlled degradation and stimulate autologous tissue repair, offering both safety and durability. These fillers meet the market's urgent demand for natural feel, low invasiveness, and personalized aesthetic outcomes. Below are typical application scenarios of PLA dermal fillers, spanning multiple fields from medical aesthetics to tissue engineering.
Deep Wrinkle Filling
PLA dermal fillers effectively fill deep wrinkles, improving dynamic facial wrinkles such as nasolabial folds and marionette lines, restoring skin firmness and smoothness, enhancing the youthful appearance of the face.
Facial Contour Shaping
Ideal for areas like the jawline, temples, and cheekbones, PLA dermal fillers can be injected to create a more three-dimensional facial contour, enhancing the contrast and definition of the face, achieving a natural aesthetic effect.
Collagen Regeneration Activation
PLA can activate fibroblasts in the skin to produce collagen, helping to improve skin elasticity and firmness. Long-term use can gradually restore the skin's original elasticity and thickness, improving sagging skin.
Post-Surgical Soft Tissue Repair
After surgery or injury, PLA dermal fillers can be used for soft tissue reconstruction and repair, promoting healing and tissue recovery at the damaged site, reducing scar formation and scar contraction.
Acne and Scar Repair
PLA effectively fills the depressed scars left by acne, promotes skin regeneration, helps restore skin smoothness and evenness, and reduces the long-term visual impact of acne scars.
Hand Rejuvenation Treatment
Injecting PLA into the back of the hand can increase subcutaneous fat, alleviate visible veins and bones, restore skin smoothness and firmness, and slow down signs of aging, making the hands appear younger.
Lip Contour Support
PLA can be used for lip contour support and shaping, enhancing the fullness of the lips, improving lip lines and laxity, giving the lips a natural, three-dimensional effect, and improving the overall facial aesthetic.
Tissue Engineering Scaffold Materials
PLA can serve as a scaffold material for tissue engineering, supporting cell adhesion and proliferation, and is widely used in biomedical research for artificial organs or tissue repair, providing a stable support environment.
FAQs
What are PLA fillers?
PLA fillers are soft tissue filling materials primarily made from poly-lactic acid (PLA), widely used in the field of medical aesthetics. They stimulate the skin's own collagen production to fill, repair, and improve skin laxity, wrinkles, and other signs of aging. Unlike traditional fillers, PLA fillers gradually degrade in the skin, continuously stimulating the skin's self-repair, resulting in natural and long-lasting effects.
What is PLA injection?
PLA injection is an injection-based aesthetic procedure that uses poly-lactic acid as a filling material to improve skin laxity, wrinkles, and facial contours. By injecting PLA microspheres into the skin, PLA stimulates fibroblasts to produce new collagen, restoring skin elasticity and firmness. The effects gradually appear after injection and last for a long time, providing a non-surgical facial rejuvenation option.
How long does PLLA filler last?
PLLA fillers typically last 1 to 2 years, with the exact duration depending on factors such as individual skin condition, lifestyle, and the injection site. PLLA fillers stimulate the skin to produce new collagen over time, providing long-term filling effects. As time progresses, PLLA naturally degrades, but the collagen synthesis-stimulating effects can last for a long period.
What is the difference between PLA and PLLA?
PLA (Poly-Lactic Acid) and PLLA (Poly-L-Lactic Acid) are both polymer materials made from lactic acid monomers, but their molecular structures are slightly different. PLA is typically made from a mixture of L-lactic acid and D,L-lactic acid, resulting in lower crystallinity. On the other hand, PLLA is formed by polymerizing pure L-lactic acid, which gives it higher crystallinity. PLLA is commonly used in medical applications such as dermal fillers due to its longer degradation cycle and better biocompatibility, offering more stable and durable effects.