Genetic Toxicology
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Genetic Toxicology

BOC Sciences provides genetic toxicology tests in compliance with relevant guidelines required for early drug discovery and clinical research application stages.


Genetic toxicology is a science that applies genetic methods to study the harmful effects and mechanisms of chemical substances and other environmental factors on the genetic material of the body. Genetic toxicology first studies the genotoxicity of chemical substances, that is, the strength of chemical substances on DNA damage and changing DNA sequences, studies the relationship between mutagenic effects, teratogenic effects and carcinogenic effects of substances, and deeply studies the mechanism of genotoxicity, for Evaluate the potential harm of chemical substances to genetic material, gene pool, etc. to provide evidence and preventive measures.

In addition to general toxicological testing, genetic toxicological testing is often required before clinical application of new drugs in order to provide evidence for safe drug use.

Service Scope

With rich experience in technical research and development and advanced experimental equipment, our research team provides comprehensive genetic toxicology services, and can customize test items according to customer needs. The test project is to detect the genotoxic damage of exogenous chemical substances on somatic cells and germ cells through in vivo and in vitro test systems, including gene mutation, DNA damage, chromosome structure distortion, chromosome number distortion, etc., so as to reveal the potential of chemical substances. mutation.

  • AMES Test
    • Bacterial Reverse Mutation Test

The bacterial reverse mutation assay is the most relevant in vitro assay for carcinogen detection. The bacterial reverse mutation (AMES) assay is used to detect gene mutations caused by DNA damage. By detecting the ability of the test substance to cause mutations in some specially constructed mutants of the test strain, that is, causing the strain to mutate from histidine/tryptophan-dependent to prototrophic, it is judged whether the test substance is a mutagen.

  • Chromosome Aberration Test

Chromosome aberrations are abnormal changes in chromosomes in somatic or germ cells. Chromosome aberrations include structural aberrations and changes in chromosome number. The chromatid or chromosome breakage induced by foreign aid factors such as breaking agent further causes chromosome deletion and rearrangement.

    • In vitro Mammalian Chromosome Aberration Test
    • Mammalian Bone Marrow Chromosome Aberration Test
    • Mammalian Spermatogonial Chromosome Aberration Test
  • Micronucleus Test

The micronucleus test is a rapid detection method for chromosomal damage and chemical toxins that interfere with cell mitosis. In the process of cell mitosis, the chromosome fragments produced by the damage of chromosome structure or the entire chromosome lost due to the damage of the spindle remain in the cytoplasm in the late stage of cell division and become micronuclei.

    • Mammalian Erythrocyte Micronucleus Test
    • In Vitro Mammalian Cell Micronucleus Test
  • Gene Mutation Test
    • In vitro Mammalian Cell Gene Mutation Test
  • Dominant Lethal Test
    • Genetic Toxicology Rodent Dominant Lethal Test

Service Process

  1. Communicate and test products, projects and requirements
  2. Send samples
  3. Determine the quotation and customize the exclusive plan
  4. Sign the contract and confidentiality agreement
  5. Start the experiment
  6. At the end of the experiment, a raw data test report will be issued
  7. Send test report