Peptide Nanoparticle Development
With years of experience in peptide synthesis and nanomaterials engineering, BOC Sciences focuses on the research, development, and preparation of high-performance peptide nanoparticles. We provide one-stop custom services for high-end markets such as medical aesthetics, cosmetics, and biopharmaceuticals, covering targeted peptide design, nanoparticle preparation, functional modification, and performance testing. Based on efficient self-assembly strategies and advanced nanomanufacturing platforms, BOC Sciences can significantly enhance the stability, bioavailability, and targeting efficiency of peptide delivery systems, endowing client products with greater technological value and market competitiveness.
Challenges in Peptide Nanoparticles That We Can Solve
Enhancing Stability of Peptide Nanoparticles
BOC Sciences enhances the physicochemical stability of nanoparticles by optimizing peptide sequences and regulating particle size and surface charge, preventing aggregation or degradation during storage and use.
Controlling Particle Size and Distribution
Through precise self-assembly control strategies and advanced preparation techniques, we control particle size within the ideal range and ensure uniform size distribution to improve product quality consistency.
Improving Skin Penetration and Cellular Uptake Efficiency
BOC Sciences enhances cellular uptake and transdermal delivery efficiency of peptide nanoparticles through surface modification, structural optimization, and functional group grafting to meet both cosmetic and therapeutic needs.
Enhancing Active Ingredient Loading and Controlled Release
We develop efficient drug-loading strategies and multi-mode controlled-release technologies to achieve excellent drug encapsulation efficiency and adjustable release profiles, delivering long-acting and stable effects.
Efficient Composite Formation of Peptides with Functional Materials
Through precise chemical grafting, covalent linkage, or non-covalent self-assembly, we efficiently integrate peptides with functional materials such as liposomes and polymers to endow them with new functionalities and structural advantages.
Ensuring Industrial Scale-up and Batch-to-Batch Consistency
With a complete process development and scale-up system, BOC Sciences achieves reproducible preparation and large-scale production of peptide nanoparticles through parameter optimization and GMP-compliant process control.
Peptide Nanoparticle Development Services
BOC Sciences specializes in the design and construction of various types of peptide nanoparticles, aiming to meet the demand for high-performance delivery systems across industries such as medical aesthetics, biomedicine, and cosmetics. We have developed a variety of functional nanoparticles based on different structural characteristics, including cyclic peptides, self-assembling peptides, peptide-polymer complexes, peptide-liposomes, and antimicrobial peptide carriers. These can be flexibly designed according to physiological environments, targeting requirements, and active ingredient properties. With an advanced material screening platform, nanotechnological preparation methods, and a comprehensive evaluation system, we offer customers personalized and diversified nanoparticle solutions, supporting product differentiation and industrial transformation.
Cyclic Peptide Nanoparticles
BOC Sciences' cyclic peptide nanoparticles possess high structural stability and excellent self-assembly properties, suitable for delivering unstable active molecules. We utilize efficient head-to-tail cyclization and side chain linkage strategies to construct multifunctional cyclic peptide frameworks, with the possibility for multi-site modifications to enhance targeting, optimize controlled release, and improve in vivo stability.
Peptide-Polymer Nanoparticles
We combine functional peptides with various synthetic or natural polymers (such as PLGA, PEG, chitosan) via covalent bonding or self-assembly to form composite nanoparticles. These carriers exhibit good mechanical stability, controlled-release modulation capability, and tissue affinity, and are widely used for the delivery of protein drugs, oligonucleotides, and nucleic acid vaccines.
Peptide-Liposome Nanoparticles
BOC Sciences integrates functional peptides with liposome technology, utilizing the membrane-penetrating, cell-recognition, and targeting capabilities of peptides to develop peptide-liposome composite nanoparticles. These systems combine the high biocompatibility of liposomes with the bioactivity of peptides, making them particularly suitable for transdermal delivery, cell targeting, and cosmetic bioactive molecule delivery.
Antimicrobial Peptide Nanoparticles
To meet the application needs of antimicrobial and cosmetic repair, BOC Sciences develops antimicrobial peptide nanoparticles that enhance their stability and long-lasting antimicrobial properties in biofilm environments. Through nanonization, we significantly improve the permeability, bioavailability, and low-toxicity profile of antimicrobial peptides. They are widely applicable in medical aesthetics, skin care, and anti-inflammatory/anti-infection products.
Peptide Nanoparticle Development Technologies
We have mature platforms for peptide synthesis, nanoparticle preparation, and functional modification, enabling full-process services from sequence design and drug-loading optimization to particle size control and large-scale production. With advanced instrumentation and a professional R&D team, we help clients overcome challenges such as structural instability, poor controlled release, and low transdermal absorption, accelerating research transformation and product commercialization.
Custom Peptide Design and Synthesis
BOC Sciences operates advanced solid-phase and liquid-phase synthesis platforms, supporting the precise customization of various peptides (linear peptides, cyclic peptides, amphiphilic peptides, functional peptides, etc.). By optimizing sequences to adjust hydrophilic-hydrophobic balance, targeting structures, and responsive structures, we lay a molecular foundation for subsequent self-assembly and functional realization.
Self-Assembled Nanoparticle Preparation Process Development
We possess systematic capabilities in peptide self-assembly process development, and can precisely construct nanoparticles with controllable size and stable morphology—such as nanospheres, micelles, vesicles, and fibers—by adjusting solvent environment, pH, ionic strength, and other parameters to meet different application needs.
Targeted Modification and Functional Molecule Grafting
BOC Sciences can graft targeting ligands and multifunctional modifications onto peptide nanoparticle surfaces, including RGD, TAT peptides, PEG, fluorophores, etc. Through efficient covalent grafting or self-assembled coating strategies, we enhance tissue localization capability, stability, and functional integration of nanoparticles.
Physicochemical Property Evaluation and Stability Testing
Equipped with advanced analytical platforms, we perform systematic characterization including particle size distribution, zeta potential, morphology, encapsulation efficiency, release profiles, and photo/thermal/storage stability to ensure repeatability and consistency of particle performance during development and subsequent application.
Active Ingredient Loading and Release Behavior Study
Based on particle structure and peptide properties, BOC Sciences can optimize loading schemes for hydrophilic or hydrophobic active ingredients and study their release behaviors under different environments. This ensures ingredient protection, sustained release, and targeted activation, providing custom delivery system support for clients.
Cellular Experiments and Skin Penetration Performance Verification
We provide cell-level uptake, toxicity, and release efficiency testing, as well as skin penetration studies using models such as the Franz diffusion cell, to evaluate the practical application potential and effects of peptide nanoparticles in cosmetic, repair, and therapeutic products.
GMP-Grade Manufacturing Capability for Peptide Nanoparticles
BOC Sciences operates advanced GMP-certified manufacturing facilities dedicated to the large-scale production of peptide nanoparticles. Our GMP production lines strictly follow international quality standards, ensuring seamless transition from R&D to large-scale manufacturing. We provide full-process services from lab-scale, pilot-scale to commercial production, ensuring quality control and consistency at all stages. Our facilities are equipped with modern reactors, homogenization equipment, ultrafiltration systems, and lyophilization technology, enabling efficient production of peptide nanoparticles under strict temperature control and sterile environments. Through meticulous management and stringent quality control systems, we ensure that each product batch meets client requirements in appearance, particle size distribution, encapsulation efficiency, and stability. BOC Sciences' GMP production capabilities not only meet the high standards of the biopharmaceutical industry but also provide high-quality and safe production support for the medical aesthetics and cosmetics sectors.
Peptide Nanoparticle Quality Testing Services
BOC Sciences understands that ensuring the quality and performance of peptide nanoparticles is a critical step in the development process. To this end, we offer comprehensive quality testing services that cover every stage—from raw materials and preparation processes to final products. With state-of-the-art laboratory equipment and standardized operating procedures, we conduct multi-dimensional performance characterizations of peptide nanoparticles to ensure their stability, safety, and efficacy in biological applications. Our quality testing services not only meet industry standards but also provide scientific data support for our clients' product development and commercialization. Whether it involves drug delivery, skin penetration, or the anti-aging effects of cosmetic products, we offer detailed analyses and reports to ensure high quality and consistency.
Analytical Items
Particle size distribution and aggregation analysis Surface charge (Zeta potential) analysis Encapsulation efficiency and drug loading analysis Morphology and surface structure observation of nanoparticles Thermodynamic stability analysis Solubility and release kinetics testing Antibacterial and cytotoxicity testing Permeability and transdermal penetration studies Stability and long-term storage testing Biocompatibility and immunogenicity assessment
Equipped Instruments
Dynamic Light Scattering (DLS) analyzer Zeta potential analyzer High-Performance Liquid Chromatograph (HPLC) Transmission Electron Microscope (TEM) Scanning Electron Microscope (SEM) Differential Scanning Calorimeter (DSC) Thermogravimetric Analyzer (TGA) Transdermal testing equipment Flow cytometer UV-Visible spectrophotometer (UV-Vis)
Applications of Peptide Nanoparticles in Medical Aesthetics and Cosmetics
With the advancement of nanotechnology, peptide nanoparticles are increasingly used in the fields of medical aesthetics, biomedicine, and cosmetics. As naturally effective bioactive molecules, peptides possess unique targeting abilities, controllability, and biocompatibility. Nanotechnology enhances their stability, permeability, and delivery efficiency, addressing the low bioavailability and instability of active ingredients in traditional formulations. Whether for skin care, anti-aging, drug delivery, targeted therapy, or disease prevention, peptide nanoparticles demonstrate significant potential. Through precision design and development, BOC Sciences provides high-quality peptide nanoparticle solutions to help clients stand out in competitive markets.
Targeted Drug Delivery
Peptide nanoparticles can achieve precise targeting of specific cells or tissues through surface modification or self-assembly. Particularly in cancer therapy, anticancer drugs or nucleic acid drugs can be loaded into peptide nanoparticles to ensure efficient release at tumor sites, enhancing therapeutic efficacy and reducing side effects.
Anti-Aging and Skin Repair
Peptide nanoparticles are widely used in anti-aging and skin repair products by enhancing the skin's permeability to active ingredients. By encapsulating active substances such as growth factors and antioxidants, these nanoparticles promote skin cell regeneration, improve elasticity, and reduce signs of aging such as wrinkles and sagging.
Wound Healing and Tissue Regeneration
In medical aesthetics and biomedical fields, peptide nanoparticles can be used for wound healing and tissue regeneration. By carrying bioactive molecules like growth factors and cytokines, these nanoparticles promote wound closure and stimulate new tissue growth, improving the recovery of skin injuries.
Vaccine Delivery and Immunotherapy
Peptide nanoparticles can serve as vaccine delivery systems by encapsulating antigens or immune-stimulating agents, enhancing antigen stability and immunogenicity. They improve immune cell recognition of vaccines and support sustained immune responses in vivo, widely applied in the prevention and treatment of infectious diseases.
Gene Therapy and RNA Delivery
Peptide nanoparticles are extensively used in gene therapy, especially in RNA delivery. As carriers for delivering genetic materials like mRNA and siRNA to target cells, they effectively promote gene expression or inhibit specific gene functions, showing strong therapeutic potential for genetic diseases and cancers.
Antibacterial and Anti-Inflammatory Effects
Peptide nanoparticles also exhibit antibacterial and anti-inflammatory properties in the fields of medical aesthetics and cosmetics, especially for treating skin conditions such as acne. Antimicrobial peptide nanoparticles inhibit bacterial growth and modulate inflammatory responses, improving skin health and playing a key role in anti-inflammatory and anti-infective therapies.
Skin Penetration and Topical Treatment
Peptide nanoparticles improve skin barrier permeability, allowing active molecules like antioxidants and vitamins to penetrate deeper into the skin for better therapeutic effects. In cosmetic products, they are used to enhance product absorption efficiency and boost the effectiveness of skincare ingredients.
Tumor-Targeted Diagnosis and Therapy
Peptide nanoparticles are increasingly used in tumor diagnosis and treatment. By labeling with specific targeting molecules, nanoparticles can accurately identify tumor cells and carry diagnostic agents or therapeutic drugs, enabling precise treatment and reducing harm to healthy tissues, offering great clinical potential.
FAQs
What is a peptide nanoparticle?
A peptide nanoparticle is a nanoscale particle composed of peptides, which are short chains of amino acids. These nanoparticles are engineered to have unique properties such as enhanced stability, bioavailability, and the ability to interact with specific biological targets. They are widely used in drug delivery, gene therapy, diagnostics, and cosmetics, owing to their biocompatibility, biodegradability, and ability to encapsulate active substances for controlled release, improving therapeutic outcomes.
What are peptide nanotubes?
Peptide nanotubes are cylindrical structures formed by self-assembling peptides. These tubes are typically created through the folding of peptides into ordered, hollow, tube-like structures. Due to their unique shape, peptide nanotubes have applications in drug delivery, biomolecular sensing, and nanomedicine. They can encapsulate drugs or other bioactive molecules, providing a controlled release mechanism, and their high surface area makes them ideal for interaction with cells or biomolecules.
What are the benefits of nano peptides?
Nano peptides offer several benefits, including improved stability, enhanced bioavailability, and targeted delivery of bioactive molecules. Their small size allows for better tissue penetration and controlled release of therapeutic agents, which can lead to reduced side effects and improved treatment efficacy. Nano peptides are also biocompatible, biodegradable, and can be easily modified for specific applications in drug delivery, diagnostics, and cosmetics, making them highly versatile for biomedical and industrial use.
What is nanoparticle conjugation with peptide?
Nanoparticle conjugation with peptides involves chemically attaching peptides to nanoparticles, enhancing the nanoparticles' ability to target specific cells or tissues. This process allows for the design of nanoparticles that can carry peptides or other bioactive molecules directly to the desired site of action. Conjugation with peptides improves the nanoparticles' specificity, stability, and efficiency in drug delivery, gene therapy, and diagnostic applications, making them more effective in treating diseases or delivering therapeutic agents.