Hyaluronic Acid Gel Development
BOC Sciences delivers high-quality customized hyaluronic acid (HA) gel production services using its sophisticated biomaterial preparation technology and rigorous quality control system. Our preparation process includes the production of hyaluronic acid raw materials followed by cross-linking modification and culminating in purification, particle size control, and quality testing of the final product. This ensures that the produced gels exhibit excellent viscoelasticity, rheological properties, and biocompatibility. Whether for medical aesthetics, tissue filling, or drug delivery and biomedical research, we provide high-performance HA gel solutions tailored to customer needs. Additionally, our GMP manufacturing capabilities meet large-scale production demands, providing stable and reliable supply chain support to global customers.
What is Hyaluronic Acid Gel?
HA gel is a cross-linked hydrogel material made from hyaluronic acid, widely applied in various fields due to its excellent biocompatibility and moisturizing properties. Hyaluronic acid is a natural polysaccharide present extensively in human tissues, particularly in the skin, joints, and eyes. Through physical or chemical cross-linking techniques, hyaluronic acid can form a gel-like network structure, which extends its in vivo degradation cycle and enhances its mechanical properties. HA gel is mainly used in aesthetic fillers (such as hyaluronic acid injections), soft tissue repair, orthopedic lubricants, wound healing materials, drug-controlled release systems, and biomedical engineering fields. In the pharmaceutical industry, HA gel serves as a drug carrier to improve drug delivery efficiency. In medical aesthetics, it is widely used for skin hydration, wrinkle filling, and contour shaping.
Technological Advantages of BOC Sciences in Hyaluronic Acid Gel
High-Purity Hyaluronic Acid Raw Materials
We use pharmaceutical-grade or cosmetic-grade hyaluronic acid, ensuring that the raw materials are free from protein residues and endotoxin contamination, meeting biomedical requirements.
Multiple Cross-Linking Technology Options
Customizable cross-linking density to optimize the gel's elasticity, viscosity, and retention time, making it suitable for medical, cosmetic, and drug delivery applications.
Optimized Gel Rheological Properties
By precisely controlling the cross-linking degree and hyaluronic acid molecular weight, we can adjust the rheological properties under different shear forces, enhancing the gel's injectability and tissue integration.
Efficient Purification and Residue Removal Technologies
Advanced dialysis and washing techniques are used to effectively remove unreacted cross-linking agents, uncrosslinked hyaluronic acid, and low molecular weight by-products, ensuring that the gel product is safe and non-toxic.
Customizable Gel Particle Size Control
By employing sieving, homogenization, and milling techniques, we produce HA gel particles of varying sizes to meet different application requirements (e.g., injection fillers, topical agents).
Strict Quality Control System
We use internationally recognized analytical methods (such as GPC, HPLC, and GC-MS) to comprehensively test molecular weight, cross-linker residue, rheological properties, and biosafety.
Large-Scale GMP Production Capacity
With GMP-compliant production facilities, we can achieve stable production from small-scale trials to commercialization, meeting the demands of the global market.
Comprehensive Application Support
Our HA gel products are suitable for medical aesthetics, orthopedic lubrication, drug delivery, tissue engineering, and more, with customized solutions available.
Types of Hyaluronic Acid Gels Supported by BOC Sciences
BOC Sciences offers various types of HA gels to meet the needs of different applications. We support two main product categories: Biphasic Gel and Monophasic Gel. Each type varies in rheological properties, elasticity, viscosity, and suitability for specific applications, with broad usage in medical aesthetics, orthopedic treatment, ophthalmic surgery, drug delivery, and tissue engineering.
Biphasic HA Gel
Biphasic HA gel (Biphasic Gel Mass) is formed by dispersing cross-linked hyaluronic acid particles in a non-cross-linked hyaluronic acid solution. Its structural features give it both the elasticity and support of a particle gel while maintaining a certain flowability, making it suitable for applications requiring higher filling volumes, such as facial shaping, deep wrinkle filling, and nose and chin contouring.
Monophasic HA Gel
Monophasic HA gel (Monophasic Gel Mass) is a uniform, cross-linked HA gel without a particle structure, offering better flowability and viscoelasticity. Its high uniformity and smoothness make it especially suitable for fine filling, cosmetic injections, joint lubricants, and tissue engineering scaffolds.
Hyaluronic Acid Nanogels
The particle size of hyaluronic acid nanogels typically ranges from 50 to 300 nm. This small size enables them to penetrate biological barriers, enhancing bioavailability. BOC Sciences offers specialized hyaluronic acid nanogel development services, providing tailored nanomaterial solutions with advanced technology and strong R&D capabilities.
Advanced Hyaluronic Acid Gel Preparation Technology Ensures High Performance
BOC Sciences offers both physical and chemical cross-linking technologies for HA gel preparation to meet diverse application needs. By optimizing the cross-linking method, we can regulate the gel's mechanical properties, biodegradation rate, and rheological characteristics, making it suitable for medical, cosmetic, drug delivery, and tissue engineering applications.
Physical Cross-Linking
Network structures are formed through hydrogen bonds, electrostatic interactions, or hydrophobic forces, without using chemical cross-linking agents, suitable for applications with high biological safety requirements, such as medical implants, drug-controlled release systems, and tissue engineering scaffolds.
Chemical Cross-Linking
Cross-linking agents (such as BDDE, DVS, EDC/NHS) are used to form stable covalent bonds between hyaluronic acid molecules, enhancing the gel's stability and durability. This method is widely used for cosmetic fillers and drug delivery systems, with cross-linking degree adjustments to control the degradation rate and viscoelasticity.
Custom HA Gel
BOC Sciences also provides customized production solutions based on customer requirements, optimizing cross-linking degree, molecular weight, viscoelasticity, durability, and other physicochemical parameters to ensure the high-efficiency application of the final product in biomedical, drug delivery, and cosmetic fields.
Efficient Hyaluronic Acid Gel Dialysis and Washing Services
During the production of HA gel, unreacted cross-linkers, by-products, and solvents may remain after the cross-linking reaction. These impurities can affect the biocompatibility, safety, and performance of the gel. To improve the purity and quality of the HA gel, BOC Sciences combines dialysis and washing techniques to remove residual cross-linkers, small molecular impurities, and solvent residues, thereby enhancing the product's biocompatibility and safety. Our precise processes ensure that the final product meets medical or cosmetic grade standards, suitable for applications such as skin fillers, ophthalmic surgical adhesives, joint lubricants, and drug delivery systems.
Professional Hyaluronic Acid Gel Screening and Grinding Processes
The particle size and uniformity of HA gel are crucial to its performance in various applications. To meet different usage requirements (e.g., skin fillers, ophthalmic surgery materials, drug delivery systems), BOC Sciences offers professional screening and grinding processes to ensure that the particle size of the HA gel is controllable, evenly distributed, and exhibits excellent rheological properties. Through high-precision screening, BOC Sciences can provide HA gels with uniform particle sizes, enhancing the gel's rheological characteristics and providing better stability and operability in filling, injection, or other applications. Our grinding process allows for adjustable particle size ranges, making it suitable for different uses, such as fillers (20–200 µm), injectable gels (100–400 µm), or ophthalmic and joint lubrication applications (500 µm and above).
Multistage Screening Technology GMP-Grade Screening Environment Mechanical Grinding Wet Grinding Temperature-Controlled Grinding
Large-Scale GMP Manufacturing Capabilities for Hyaluronic Acid Gel
BOC Sciences has GMP-compliant production facilities that can conduct large-scale HA gel manufacturing, ensuring stable product quality and compliance with international regulatory requirements. Our GMP factory is equipped with advanced production equipment and a strict quality control system, capable of meeting the demands of the pharmaceutical, medical device, and cosmetics industries. Additionally, our production processes are customizable, supporting the entire process from small trials and pilot-scale to commercial production. We can adjust the cross-linking degree based on different application requirements to optimize the gel's rheological properties and biodegradation rate, ensuring optimal performance in various scenarios. Furthermore, we provide low, medium, and high molecular weight HA gels, suitable for different industry needs. Through meticulous screening and grinding techniques, we can achieve gels with different particle size distributions, widely applicable in fillers, ophthalmic surgery, and biomaterials. To improve gel operability in injection applications, we also offer customized viscosity and rheological properties, particularly in adjusting shear-thinning behavior, to meet various high-demand applications.
Analysis Testing and Quality Control of Hyaluronic Acid Gel
BOC Sciences uses advanced analytical technologies to conduct comprehensive quality testing of HA gel, ensuring the safety, stability, and consistency of product performance. Our testing services cover multiple aspects to ensure that each batch of HA gel meets stringent quality standards and satisfies different application needs.
Instrumentation
Gel Permeation Chromatography (GPC) Rheology Tester High-Performance Liquid Chromatography (HPLC) Gas Chromatography-Mass Spectrometry (GC-MS) UV-Vis Spectrophotometer Stability Testing Chamber Particle Size Analyzer Nuclear Magnetic Resonance (NMR) Fourier-Transform Infrared Spectroscopy (FTIR) Mass Spectrometry (MS)
Testing Items
Raw Material Testing Molecular Weight Analysis Viscosity Testing Particle Size Analysis Rheological Analysis Microbial Testing Endotoxin Testing Stability Testing Residual Cross-Linker Testing Biocompatibility Testing
Service Workflow
Research and Production Application Support by Hyaluronic Acid Gel
HA gel, as an important biomaterial, is widely used in multiple fields due to its excellent biocompatibility, moisturizing, repairing, and biodegradable properties. Its unique molecular structure and characteristics have led to significant achievements in medicine, cosmetics, drug delivery, and tissue engineering. BOC Sciences' HA gel extensively supports the following research and industrial production applications, showcasing its outstanding functionality and potential in various fields:
Aesthetic Medicine
Cross-linked hyaluronic acid is widely used in aesthetic medicine as a long-lasting filler for facial shaping, wrinkle removal, and skin repair, offering both safety and durability.
Cosmetics
Its powerful moisturizing ability makes hyaluronic acid a key ingredient in many premium creams, serums, and masks, effectively improving skin hydration, delaying the aging process, and making the skin appear softer and more elastic.
Orthopedics and Joint Treatment
HA gel plays a critical role as a lubricant in orthopedics and joint treatment. It can effectively improve joint mobility and relieve symptoms of arthritis, osteoarthritis, and other conditions.
Drug Delivery
Due to its biocompatibility and biodegradability, hyaluronic acid can achieve long-term drug release and allow for controlled adjustments to the drug release rate as needed, ensuring maximum benefit at the target site and reducing side effects.
Tissue Engineering
Due to its excellent cell adhesion and ability to promote cell proliferation, it is used as a cell scaffold material to help promote tissue regeneration and shorten wound healing times.
Ophthalmic Surgery
Hyaluronic acid is used as a viscoelastic agent in ophthalmic surgeries to protect the cornea and maintain intraocular space. Modified hyaluronic acid can extend its residence time within the eye.
Medical Device Coatings
Surface-modified hyaluronic acid can be used for coating medical devices, imparting antimicrobial properties, anti-adhesion effects, and biocompatibility, thereby reducing postoperative infections and complications.
Biosensors
Modified hyaluronic acid can be applied in the development of biosensors, where functional groups are introduced to enhance the sensor's sensitivity and specificity.
FAQs
How to make hyaluronic acid gel?
The production of hyaluronic acid gel is typically achieved by reacting sodium hyaluronate (HA) solution with a cross-linking agent. First, sodium hyaluronate is dissolved in water to form a hyaluronic acid solution. Then, cross-linking agents such as EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) or BDDE (bis(2-hydroxyethyl) disulfide) are added to cross-link the hyaluronic acid molecules to form a gel. The pH and temperature are then adjusted to promote the cross-linking reaction, followed by filtration, purification, and other steps to obtain the final hyaluronic acid gel product.
What is hyaluronic acid gel used for?
Hyaluronic acid gel is widely used in medical aesthetics, orthopedic treatment, drug delivery, and tissue engineering. In medical aesthetics, it is used for facial filling and wrinkle repair, as well as improving skin hydration. In orthopedic treatment, hyaluronic acid gel is used for joint lubrication to relieve symptoms of osteoarthritis. In drug delivery, hyaluronic acid gel acts as a carrier for sustained and targeted delivery. Additionally, it is widely used in soft tissue repair and the development of artificial organ scaffolds.
Is Hyaluronic gel a moisturizer?
Yes, hyaluronic acid gel can act as a moisturizer. Hyaluronic acid has significant water-absorbing properties, capable of drawing moisture from the air or deep within the skin and locking it in, thereby helping to maintain skin moisture. When applied to the skin, hyaluronic acid gel effectively attracts and retains moisture, providing deep hydration and improving skin hydration and elasticity. Therefore, it is commonly used in skincare products as an effective ingredient for moisturizing and enhancing skin smoothness.