Polynucleotide Preparation Services
BOC Sciences has a leading biotechnology platform focused on the extraction, purification, and preparation of polynucleotides (PN). With extensive experience in nucleic acid separation and advanced production equipment, we are able to provide high-purity, high-quality PN raw materials that meet the stringent requirements of industries such as healthcare, pharmaceuticals, cosmetics, and more. Our extraction and purification processes are rigorously optimized to ensure that PN reaches industry-leading standards in terms of bioactivity, molecular weight control, and stability. Additionally, we have GMP-scale production capabilities, ensuring product repeatability and efficient supply. Supported by a strong R&D team, BOC Sciences continues to refine extraction technologies and improve product quality to meet the diverse application needs of various fields.
What are Polynucleotides?
Polydeoxyribonucleotides (PDRN) are short-chain nucleotides extracted from salmon sperm DNA, characterized by a small molecular weight, stable structure, and enhanced skin penetration. Polynucleotides (PN) are secondary refined products of PDRN, with larger molecular weight and more complex structures, offering more lasting regenerative effects. PN exhibits strong bioactivity and plays a critical role in cell repair, anti-inflammatory responses, tissue regeneration, and immune regulation. In recent years, PN has gained prominence in the pharmaceutical, medical device, cosmetics, and regenerative medicine sectors due to its excellent biocompatibility and tissue repair properties. For example, in the medical field, PN is used as a tissue repair promoter for wound healing, skin grafting, and bone tissue engineering. In cosmetics, PN is incorporated into high-end skincare formulations due to its ability to promote collagen synthesis and enhance skin barrier function. Furthermore, PN has broad applications in gene therapy, cell culture, and biomaterials development.
Advantages of BOC Sciences in Polynucleotide Preparation
Advanced Extraction Technology
By employing efficient enzymatic digestion, ultrafiltration, and chromatographic separation technologies, we enhance PN purity, reduce impurities, and ensure high bioactivity.
Precise Molecular Weight Control
We optimize nucleic acid degradation processes and customize PN within different molecular weight ranges to meet various application needs in pharmaceuticals, skincare, and research.
GMP-scale Production
With GMP-compliant production facilities and a rigorous quality management system, we ensure the stability and batch consistency of products in large-scale production.
Strict Quality Control
We conduct comprehensive testing on PN using HPLC, mass spectrometry, electrophoresis, and other analytical techniques to ensure products meet industry standards and regulatory requirements.
Diverse Product Specifications
We offer PN raw materials in various forms, including powder, liquid, and gel, to meet the diverse needs of pharmaceuticals, medical devices, skincare, and research.
Strong Industry Compatibility
Our products meet medical-grade, medical device-grade, and cosmetic-grade standards and can be customized to specific PN product specifications based on customer requirements.
Robust R&D Support
Our professional R&D team is dedicated to optimizing PN extraction and purification technologies and providing personalized customization services to meet the needs of different research fields.
Rapid Delivery Capability
Leveraging a comprehensive production and logistics system, we ensure global customers receive high-quality PN raw materials quickly, enhancing research and production efficiency.
Polynucleotide Raw Materials Provided by BOC Sciences
BOC Sciences focuses on the extraction, purification, and preparation of PN, offering a wide range of PN raw materials in different specifications and for various uses to meet the needs of different fields. Our PN raw materials cover industries such as pharmaceuticals, medical devices, cosmetics, and research, ensuring that the products comply with industry standards and exhibit excellent biocompatibility and bioactivity. PN has become an essential functional ingredient in the pharmaceutical and skincare industries due to its effectiveness in cell repair, anti-aging, tissue regeneration, and moisturizing repair. With advanced production processes and a strict quality control system, BOC Sciences provides PN products in various forms, from powders to liquids and gels, ensuring clients in drug development, skincare production, and medical research can access high-quality, sustainable PN raw materials. Below are the main PN raw material categories we offer:
Medical Device-grade PN Raw Materials
We provide medical device-grade PN raw materials that undergo rigorous quality inspection and comply with relevant medical device standards. These materials can be used in wound dressings, postoperative recovery dressings, skin repair materials, etc.
Medical-grade PN Raw Materials
Medical-grade PN raw materials are widely used in drug formulations, such as ophthalmic drugs, joint repair agents, and wound care products. These materials meet pharmacopoeia-level quality standards and effectively promote skin and mucosal regeneration, offering strong anti-inflammatory effects.
Cosmetic-grade PN Raw Materials
Our cosmetic-grade PN raw materials are focused on skincare applications. They significantly improve skin elasticity and radiance, reduce fine lines, wrinkles, and other signs of aging, and are suitable for high-end skincare formulations such as serums, lotions, and creams.
Gel-form PN Raw Materials
Gel-form PN raw materials offer better penetration, helping skincare ingredients to be absorbed deeper into the skin. Their high viscosity and unique texture make them ideal for use in serums, face creams, and therapeutic gels, providing long-lasting moisture and repair for the skin.
Polynucleotide Extraction Technology by BOC Sciences
BOC Sciences uses advanced PN extraction and purification technology to ensure that the PN raw materials we provide have high purity, good bioactivity, and stability. Our technological processes cover every step from raw material treatment to final product, strictly controlling each phase to ensure the final product meets the application requirements of industries such as pharmaceuticals, medical devices, and cosmetics. By continuously optimizing extraction processes and technical equipment, BOC Sciences offers efficient, sustainable, and cost-effective PN extraction solutions. We are committed to providing high-quality PN raw materials to global clients and support customized production. Below is an overview of our extraction technology process:
Raw Material Treatment
The first step in PN extraction involves collecting raw materials from plant, animal, or microbial sources and removing impurities using physical and chemical methods, ensuring the initial material is suitable for further extraction.
Cell Lysis
We use cell lysis technology to break the cell membranes of biological source materials, releasing the nucleic acid components. This step ensures the efficient extraction of nucleic acids from complex cellular matrices.
Nucleic Acid Extraction
We employ efficient solvents and enzymatic methods, combined with ultrafiltration technology, to extract DNA from the lysate. This process is strictly controlled to ensure the high quality and activity of the nucleic acids.
Nucleic Acid Degradation
Using enzymatic hydrolysis (e.g., nucleases) or physical methods, we appropriately degrade nucleic acid molecules to regulate their molecular weight distribution to meet the PN molecular weight requirements for various applications.
Purification and Concentration
We use advanced chromatography and centrifugation technologies to purify the extracted nucleic acids, remove any residual impurities, and concentrate them to the ideal concentration, enhancing bioactivity for subsequent applications.
Quality Testing
After each critical step, we conduct rigorous quality testing using HPLC, UV spectrophotometry, and other instruments to ensure the quality and bioactivity of each batch.
Lyophilization and Formulation
To improve product stability and convenience, we lyophilize the purified PN and provide liquid or solid formulations based on customer requirements, making them suitable for long-term storage and transportation.
Packaging
Finally, the tested and approved products are packaged. The packaging process follows GMP standards to ensure the stability and safety of the products during transport and storage.
GMP Manufacturing Capabilities of Polynucleotides
BOC Sciences has extensive experience in the extraction, purification, and production of PN, and possesses advanced GMP scalable manufacturing capabilities. Our production facilities meet international pharmaceutical production standards, equipped with efficient production lines and precision equipment to meet the global market's demand for high-quality PN raw materials in large quantities. Whether for small-batch custom orders (grams) or large-scale production (kilograms), we provide highly flexible solutions to support the needs of pharmaceuticals, medical devices, cosmetics, and research institutions. Our production facilities are equipped with advanced automated production equipment, fully enclosed clean rooms, and efficient quality control laboratories, ensuring that each batch of products meets GMP standards from raw materials to final formulations. We maintain strict operational procedures in areas such as sterile production, temperature-controlled storage, contamination control, and waste management, ensuring the purity, stability, and biological activity of the products.
Polynucleotide Quality Testing Services at BOC Sciences
Quality control is a critical step in ensuring that products meet high standards during the PN production process. BOC Sciences understands the importance of product quality in determining the effectiveness of the final application. Therefore, we offer comprehensive and efficient quality testing services to ensure that each batch of PN raw materials meets or exceeds industry standards. Our quality testing services cover every production step, from raw materials to final formulations, using advanced analytical techniques to strictly evaluate the purity, structure, activity, and stability of PN. Whether for research purposes, drug development, or applications in cosmetics and medical devices, BOC Sciences' quality testing services provide precise results, ensuring product safety and efficacy.
Testing Instruments
High-Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) UV-Visible Spectrophotometer (UV-Vis) Gel Electrophoresis Analyzer Mass Spectrometer (MS) Nuclear Magnetic Resonance (NMR) Flow Cytometer (FACS) Fluorescent Quantitative PCR Instrument
Analytical Items
Molecular Weight Distribution Measurement Purity Testing Biological Activity Evaluation Microbial Limit Testing Endotoxin Testing Moisture Content Testing pH Measurement Stability Studies
Polynucleotide Applications in Cosmetics and Medicine
In the fields of cosmetics and medical aesthetics, PN has become one of the key ingredients due to its unique biological activity and repair functions. PN effectively promotes cell regeneration, improves skin barrier function, delays the aging process, and demonstrates significant effects in anti-aging, repair moisturizing, and skin healing. As a result, PN is widely used in various cosmetic and medical aesthetic products, especially in research areas related to facial care, anti-aging, and wound healing.
Moisturizing and Hydrating Research
PN can enhance skin barrier function, reduce water loss, and is therefore used in moisturizing products. It deeply moisturizes the skin and helps maintain hydration, improving dry and rough skin conditions.
Whitening and Brightening Research
The application of PN in whitening has gained considerable attention. Research has shown that PN can regulate the distribution of skin pigments, effectively reduce melanin deposition, and improve skin brightness and evenness. It is commonly used in whitening products to help improve uneven skin tone.
Anti-inflammatory and Soothing Research
The anti-inflammatory effects of PN are highly valuable in the cosmetic and aesthetic fields, particularly in relieving skin inflammation and allergic reactions. It effectively soothes symptoms such as skin redness and allergies caused by environmental stimuli or chemical product use.
Antioxidant Research
PN is rich in natural antioxidants, which can resist free radical damage caused by UV radiation and air pollution, thereby protecting the skin from environmental factors and delaying the aging process. Its application in antioxidant skincare products has increased, making it an essential ingredient in daily skincare.
Mask and Gel Ingredient Research
PN is widely used in masks and gel products to provide deep nourishment and repair. Combined with other moisturizing ingredients, PN enhances the effectiveness of masks and gels, boosting skin absorption and repair capabilities, while maintaining skin hydration and radiance.
Cell Repair and Regenerative Medicine
PN promotes cell proliferation and tissue repair, making it widely applied in regenerative medicine for skin wounds, arthritis, eye diseases, and more. It accelerates wound healing and promotes the growth of new tissues.
Anti-aging and Skin Care Research
PN is researched for its role in anti-aging and skin repair, primarily focusing on promoting collagen synthesis, improving skin barrier function, and enhancing skin elasticity. Studies show that PN significantly improves the condition of aging skin.
Drug Delivery System Research
In drug development, PN is used in the preparation of nanoparticle drug delivery systems. It effectively protects the drug components from degradation while enabling precise drug release, enhancing therapeutic efficacy.
FAQs
Do polynucleotides work?
Polynucleotides (PN) play an important role in biological and medical research and have significant biological activity. They promote cell regeneration, repair damaged tissues, regulate immune responses, and enhance skin barrier function. In the fields of cosmetics and medical aesthetics, PN is widely used for anti-aging, moisturizing, repair, and promoting wound healing. Through their unique structure and function, PN has proven effective in various applications, particularly in research focused on improving cell vitality and promoting tissue regeneration, showing great potential.
Are polynucleotides filler?
Polynucleotides (PN) are not fillers. They possess biological activity and are widely used in medical and cosmetic fields, especially in anti-aging, skin repair, and wound healing. PN promotes cell regeneration, improves the skin barrier, and accelerates tissue repair, contributing to skin health. They are not merely functional ingredients, but through their unique molecular structure and biological effects, they truly support skin and tissue regeneration, making them far more than just fillers.
Are polynucleotides safe?
Polynucleotides (PN) are generally safe, especially when subjected to strict quality control and testing. They are widely used in cosmetics and medical aesthetic products and show no significant adverse reactions in most populations. PN has good biocompatibility and low toxicity, making it suitable for skincare and wound repair. However, sensitive individuals may experience allergic reactions, so a patch test is necessary before use. Overall, PN is safe in compliant production and usage processes.