Polycaprolactone (PCL) Services
BOC Sciences is committed to providing high-quality custom development and preparation services for polycaprolactone (PCL) and its microsphere formulations to clients in industries such as medical aesthetics, cosmetics, and biomedicine. Our services cover medical-grade, cosmetic-grade, and industrial-grade PCL materials and microspheres, including PCL microsphere preparation and modification, PCL nanoparticle development, PCL hydrogel systems, PCL filler design, and PCL formulation development. We also offer systematic quality testing and in vivo and in vitro biological evaluation services. Leveraging an advanced material synthesis platform and a standardized quality control system, BOC Sciences provides a one-stop solution from early-stage R&D to GMP manufacturing, supporting the commercialization of high-value-added products in next-generation material science.
Advantages of BOC Sciences in PCL Services
Medical Aesthetic Microsphere Customization Ability
Focused on the particle size control and uniformity of PCL microspheres for medical aesthetic uses, meeting the professional needs of injection filling and durable repairs.
Support for Multiple Specifications of PCL Platform
Providing a variety of PCL products ranging from medical-grade to cosmetic-grade and industrial-grade, meeting the development standards for different formulations across industries.
Dual Development of Nanoparticles and Hydrogels
Supporting the parallel development of PCL nanoparticles and hydrogels to meet the needs of controlled-release drug delivery, skin penetration, and regenerative medicine.
Multi-mode Microsphere Modification Technology
Enabling physical encapsulation, surface grafting, and functional modification to enhance the bioactivity and targeting ability of PCL microspheres.
Complete GMP Manufacturing and Quality Control System
Equipped with a cGMP-certified production environment and a comprehensive quality control system, supporting large-scale production and registration filings.
One-Stop Testing and Regulatory Compliance Services
Providing full-process services from in vivo and in vitro evaluation to efficacy testing, helping clients achieve product compliance and efficient market entry.
PCL Development Services Offered by BOC Sciences
BOC Sciences possesses an advanced polymer materials platform and an interdisciplinary R&D system, committed to offering high-quality custom development services for PCL and its microsphere formulations in biomedicine, medical aesthetics, and cosmetics. We not only achieve the fine synthesis of basic PCL raw materials but also provide development support for various formulation forms, including microspheres, nanoparticles, hydrogels, and fillers, according to customer needs. Our services cover material modification, formulation optimization, process scale-up, and biological performance evaluation, assisting clients in accelerating product transformation and market launch.
PCL Microsphere Preparation
BOC Sciences can synthesize PCL microspheres within a range of particle sizes (1 μm to 100 μm) according to customer needs, widely used in controlled-release drug carriers, skin filling materials, and cosmetic active ingredient encapsulation. We use processes such as emulsion polymerization, spray drying, and solvent evaporation to precisely control particle size uniformity, encapsulation efficiency, and degradation rates.
PCL Microsphere Modification
To meet specific application needs, we offer various modification strategies, including surface functionalization (carboxyl/amino), shell coating (PEGylation, PLGA encapsulation), adding hydrophilic/hydrophobic adjustment components, and drug release regulation layers (e.g., sustained-release coatings). These technologies help improve the tissue compatibility, drug release performance, and targeting ability of microspheres.
PCL Nanoparticle Development
BOC Sciences has a mature platform for PCL nanoparticle preparation, suitable for encapsulating small molecules, proteins, peptides, etc. Common applications include transdermal absorption, targeted drug delivery, and nanoparticle-based cosmetic systems. We offer highly dispersive nanoparticles with particle sizes<200 nm and PDI <0.2, supporting encapsulation efficiency and drug release curve customization.
PCL Hydrogel Development
Based on the copolymerization or crosslinking strategies of PCL and hydrophilic polymers, we have developed a series of PCL hydrogel systems with both mechanical strength and biodegradability. These are widely used in tissue engineering scaffolds, facial mask substrates, skin repair patches, and other fields. We can regulate the gel strength, crosslinking density, release behavior, and degradation cycle.
PCL Filler Development
We provide several PCL-based injectable or topical filler development services for medical aesthetic clients. We can customize physical parameters such as particle size, viscoelasticity, and degradation cycle based on the client's target area requirements, ensuring the biological safety and tissue affinity of the products. These have been applied to facial contour restoration, skin smoothing, and anti-aging products.
PCL Formulation Development
BOC Sciences offers PCL-based composite formulation development services, including the design of composite systems blended with various polymers (e.g., HA, PLGA, PEG). We can regulate the rheological properties, release characteristics, and physical stability of the system to meet different clinical or cosmetic needs.
GMP Manufacturing Capability of PCL
BOC Sciences possesses a full-process PCL microsphere formulation manufacturing capability, ranging from laboratory R&D, pilot scale-up, to industrial-scale production. We are equipped with GMP-compliant manufacturing facilities, including clean areas, closed reaction systems, high-precision emulsification equipment, spray drying and freeze-drying systems, ensuring the preparation of products in a sterile and stable environment. Additionally, we have pilot-scale and large-scale production capabilities, from material screening and small-batch validation to commercial-scale production. The company strictly adheres to GMP quality systems under ICH and FDA guidelines, covering raw material traceability, process validation, environmental monitoring, and batch release, providing high-quality, traceable, and registerable PCL microsphere products for medical aesthetic, cosmetic, and biomedical clients.
PCL Quality Testing Services by BOC Sciences
BOC Sciences has established a comprehensive quality testing system, covering the physical and chemical properties, biological performance, and in vivo and in vitro behavior of raw materials, intermediates, and final products. We are equipped with advanced analytical instrumentation platforms, including particle size analyzers, scanning electron microscopes (SEM), thermal analyzers (DSC/TGA), nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), high-performance liquid chromatography (HPLC), and more, enabling multidimensional performance characterization. We also offer in vitro release, degradation kinetics, cell compatibility, animal testing, and other evaluation services in compliance with ICH and ISO standards, providing strong data support for PCL microsphere registration and clinical transformation. BOC Sciences is committed to providing clients with high-quality, full-process, one-stop testing solutions.
PCL Quality Testing Services
Particle Size Distribution and Uniformity Encapsulation Efficiency and Drug Loading Surface Morphology Observation Thermal Stability Analysis Molecular Weight Determination Release Curve Testing pH Stability Testing Moisture Content Detection Heavy Metal and Residual Solvent Analysis Sterilization Validation and Microbial Limit Testing
PCL In Vivo/In Vitro Testing Services
In vitro Degradation Rate Evaluation (PBS System) Cytotoxicity Test (MTT/CCK-8) Cell Adhesion and Proliferation Assays Animal Injection Tolerance Tests Skin Irritation and Allergy Testing Local Tissue Inflammatory Response Tests Biocompatibility Evaluation Drug Release Kinetics Analysis (In Vivo) Tissue Distribution and Metabolic Tracking Long-term Implantation and Tissue Repair Evaluation
Applications of PCL in Medicine and Aesthetics
As a biodegradable, highly biocompatible aliphatic polyester material, PCL is widely used in the fields of medical aesthetics, cosmetics, and biomedicine due to its controllable degradation, excellent mechanical strength, and flexible modification options. Particularly, the innovative development of various formulations, such as PCL microspheres, nanoparticles, and hydrogels, has shown great potential in numerous applications, including facial filling, skin regeneration, active ingredient controlled release, tissue engineering, and vaccine delivery. BOC Sciences offers customized PCL products and formulation development solutions to help clients achieve innovative integration of precise treatment, aesthetic repair, and smart skincare, accelerating product clinical transformation and market deployment.
Injectable Fillers
PCL microspheres, as long-acting injectable fillers, offer good tissue compatibility and controllable degradation characteristics. They can replace hyaluronic acid for deep facial shaping. Upon implantation, they provide immediate filling and, through slow degradation, stimulate collagen regeneration, maintaining effects for 12 to 24 months. This makes them suitable for fine contour reshaping in areas like the apples of the cheeks, nasolabial folds, and jawline.
Collagen Synthesis Promoters
After subcutaneous injection, PCL microspheres can activate fibroblast function through slow-release degradation, promoting the generation of collagen and elastin, thereby enhancing skin elasticity and firmness. This method does not require frequent injections, making it ideal for non-surgical anti-aging treatments for facial aging and skin laxity, offering a sustainable skin remodeling solution for clinical and high-end aesthetic institutions.
Tissue Scaffold Materials
PCL scaffolds with a porous structure provide good mechanical strength and adjustable degradation rates, making them widely used in tissue engineering and soft tissue repair. They can be used as supporting structures in facial lifting, fat filling, and other surgeries, enhancing fat survival rates and post-surgery stability. Its high biocompatibility makes it an ideal choice for tissue regeneration materials in medical aesthetics.
Active Ingredient Controlled Release Microspheres
PCL microspheres efficiently encapsulate functional ingredients such as vitamins, peptides, and antioxidants, providing sustained and stable controlled-release effects. The protective function of the carrier prevents oxidation or degradation of the ingredients, significantly improving the stability and penetration efficiency of skincare products. This makes it suitable for the development of high-end skincare formulations like serums and anti-aging creams, fulfilling the long-term efficacy release needs.
Smart Skincare Systems
Incorporating thermosensitive or pH-responsive mechanisms, PCL microspheres can control the release of active ingredients based on environmental changes, such as triggering release when skin temperature rises or pH changes. This smart system can be embedded in emulsions, serums, or sunscreens to achieve targeted effects and controlled release, driving the innovation of personalized and precise skincare formulations. It is a key platform for the future of smart skincare products.
Face Masks and Patch Carriers
PCL hydrogels, with their flexible, skin-friendly, and controllable degradation properties, can be used to develop high-adhesion face masks or patch products that deliver active ingredients for targeted, sustained release. Combined with ingredients like hyaluronic acid and plant extracts, they are ideal for whitening, repairing, and soothing, widely applied in professional salon treatments and functional home-care products.
Drug Controlled Release Systems
As a drug delivery carrier, PCL has biodegradability and excellent controlled-release properties, commonly used to encapsulate anticancer, anti-inflammatory, or antimicrobial drugs for local targeted release and sustained treatment. It can be applied through injection, implantation, or topical application in post-surgery care, local inflammation treatment, and adjunctive cancer therapy across various medical directions.
Vaccine Delivery Platforms
PCL nanoparticles can stably encapsulate antigens or adjuvants for subunit vaccine delivery systems, improving immunogenicity and durability. They are suitable for intramuscular or subcutaneous injections, promoting the activation of both humoral and cellular immune responses. This supports the development of flu vaccines, cancer vaccines, and vaccines for emerging infectious diseases, making it an important candidate material for modern immunotherapy carriers.
FAQs
Is polycaprolactone toxic?
Polycaprolactone (PCL) is a low-toxicity, highly biocompatible synthetic polymer material that degrades slowly into non-toxic small molecules in the body. It is widely used in medical aesthetics, drug delivery, tissue engineering, and other fields. Extensive research and clinical data show that PCL is non-toxic and non-sensitizing to humans, making it a recognized safe material.
What is the use of PCL in medicine?
In medicine, polycaprolactone is used for absorbable sutures, orthopedic scaffolds, injectable fillers, controlled-release drug carriers, and tissue engineering scaffolds. Its controllable degradation and excellent biocompatibility make it an ideal material for regenerative medicine and personalized healthcare, supporting diverse applications from wound repair to cancer treatment.
What is polycaprolactone used for in dentistry?
Polycaprolactone is used in dentistry for alveolar bone repair scaffolds, degradable dental membranes, root canal filling materials, and more. Due to its slow degradation properties and biocompatibility, PCL promotes periodontal tissue regeneration, supports the structural stability of bone substitute materials, and is developed as a carrier in dental aesthetic products to aid in dental regeneration and functional recovery.
What is the PCL repair technique?
The PCL repair technique utilizes the degradability and good biocompatibility of polycaprolactone, widely applied in tissue repair and regenerative medicine. Common PCL repair techniques include using PCL scaffolds to promote tissue or bone regeneration, applied in wound repair, soft tissue regeneration, etc. As a scaffold material in orthopedics, dentistry, and skin regeneration, PCL gradually degrades in the body while providing structural support for new tissues.
Is liquid PCL safe?
Liquid PCL is safe under appropriate conditions, especially in medical and biomedical applications. It is commonly used in drug delivery systems, injectable fillers, and wound dressings. Liquid PCL has good biocompatibility and can degrade into non-toxic small molecules in the body, usually not causing toxic reactions. However, quality and concentration must be strictly controlled during use to ensure safety.
What is PCL injectable?
PCL injectable refers to polycaprolactone used as a carrier or filler material applied through injection in medical aesthetics and therapeutic fields. It can be used for facial contour shaping, wrinkle filling, or promoting skin repair. PCL injectables provide long-lasting, sustained-release effects with good biocompatibility, remaining active for months or even over a year after injection, gradually being absorbed by the body.