Nanoparticle Drug Delivery System Modification

The revolutionary breakthrough of nanotechnology in the field of drug delivery not only broadens the therapeutic boundaries of traditional drugs, but also creates a targeted, controllable and efficient treatment path. BOC Sciences, as a biopharmaceutical company focusing on nanomedicine preparations, relies on its deep scientific research foundation and cutting-edge technology platform to provide a series of comprehensive and professional nanoparticle modification services, dedicated to optimizing the performance of nanoparticles in therapeutic drugs to achieve more accurate drug delivery.

Methods of nanoparticle modification

Chemical modification: Chemical modification technologies, such as amination, esterification, phosphorylation, etc., accurately connect functional groups to the surface of nanoparticles or carriers through covalent bonding, giving nanomaterials new properties such as targeting, drug loading capacity and biocompatibility. This process not only enhances the drug delivery efficiency of the nanocarriers, but also enables precise control of the drug release rate.

Physical modification: Physical modification technologies, such as electrodeposition, self-assembly, electroadsorption, etc., use physical forces to firmly adsorb modified molecules on the surface of nanoparticles, and improve the performance of nanoparticles without chemical reactions. This modification method can not only effectively improve the stability of nanoparticles, but also enhance their biocompatibility in complex physiological environments.

Biological modification: Biological modification strategy, through the use of biological molecules (such as proteins, peptides, antibodies, etc.) and the specific interaction with nanocarriers, to achieve precise targeted drug delivery. This technology not only strengthens the biometric identification ability of nanoparticles, but also significantly improves the targeting efficiency and biosafety of drugs.

Our nanoparticle modification services

Nano formulation customization

BOC Sciences' team of scientists, with extensive practical experience, provides personalized nanoparticle formulation customization services. By precisely regulating parameters such as the size, surface charge and hydrophobicity of the nanoparticles, each nanomedicine formulation can be perfectly matched to its therapeutic goals and achieve superior therapeutic results. We use a wide range of materials and advanced preparation technologies such as natural polymers, synthetic polymers, biodegradable polymers, nano-metals and composites to create highly customized nanoparticle formulations.

Security modification

Security modification services, through physical encapsulation, molecular protection and group introduction and other strategies, effectively inhibit or eliminate the blood reaction, immune response and tissue reaction caused by nanoparticles, greatly improve the safety of drugs. This process ensures that the nanomedicine can run smoothly in the human body, avoiding potential side effects.

Validity modification

Physical effectiveness: Design physical properties such as porosity, elasticity, mechanical strength and fatigue strength of nanoparticles to adapt them to specific drug release needs and ensure accurate drug release.

Chemical effectiveness: By fine-tuning the surface tension, hydrophilicity, charge properties, chemical specificity, drug resistance, degradability and long cycle of nanoparticles, the stability and delivery efficiency of drugs are optimized to ensure the stable existence of drugs in complex physiological environments. PEGylation is a commonly used long-cycle modification method in which the introduction of PEG chains on the surface of nanoparticles can reduce their non-specific binding to plasma proteins, thereby extending their circulation time in the body.

Bioavailability: The use of biological modification technology to regulate the enzymatic action and inhibition of enzymes in vivo, maintain the stability and pharmacokinetic properties of drugs or ligands, and ensure the effective use of drugs in vivo.

Intelligent modification

Stimulus response: The development of PH-sensitive, oxidation-reduction, photothermal effect type of nano preparations, so that drugs in specific physiological or pathological conditions in response to external stimuli and release, to achieve precision treatment.

Detection sensor: The use of organic fluorophores, inorganic quantum dots fluorescence, magnetic particles, etc., to achieve real-time monitoring of drug delivery process, providing visual basis for drug delivery control.

Targeted modification: The surface of the drug is decorated with specific ligands, such as antibodies or peptides, to achieve active targeted delivery of the drug, accurate identification and use for diseased cells, and improve the pertinency of treatment. Lipid nanoparticles do not usually present reactive groups on their surface. Therefore, noncovalent and covalent techniques have been developed to decorate lipid nanoparticle drug delivery system with targeting ligands.

Fig. 1 Noncovalent surface modification techniques. (a) Lipid anchor inserted in the membrane during formulation or by postinsertion and examples of lipid anchors. (b) Ionic interaction by electrostatic or NTA-nickel-His-tag chelation. (c) Biological interaction with streptavidinbiotin or folate-folate binding protein. (Xu, Y., 2022)

Controlled release technique

The innovation of controlled release technology enables the nanoparticle to achieve pulsed, timely and appropriate drug release under the action of internal (such as pH, enzyme, REDOX) or external (such as magnetic, thermal, electrical, light) stimuli, which greatly improves the accuracy of treatment and the quality of life of patients.

Analysis and quality assurance services

Our laboratories are equipped with world-class analytical instruments, including dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), thermogravimetry (TGA) and high performance liquid chromatography (HPLC). These cutting-edge tools form the core of our analytical services, enabling comprehensive and in-depth characterization of nanomedicine.

In addition to basic analytical characterization, we offer a comprehensive range of stability and shelf life testing services. These tests simulate different environmental conditions (such as temperature, humidity, light, etc.) to assess the physical and chemical stability of nanomaterials, monitor the rate of drug degradation, and predict shelf life.

Advantages of our nanoparticle modification services

Advanced technology: We have industry-leading nanomedicine delivery technologies, including microfluidic synthesis, targeted ligand binding, stimulus-responsive design, and more.

High-end equipment: Our laboratory is equipped with advanced experimental equipment, such as microfluidic chip system, high pressure homogenizer, particle size analyzer, drug release test system, etc., to ensure the high efficiency of research and development and high quality of products.

Professional team: Our team is composed of experts with rich experience in pharmaceutical chemistry, nanotechnology, biomedicine fields, and can provide professional technical support and consulting services.

Customized services: We provide customized services to design and optimize nanomedicine delivery systems according to the specific needs of our customers.

Comprehensive evaluation: We conduct a comprehensive performance evaluation of nanomedicine delivery systems to ensure their safety and effectiveness.

Quick response: We are able to respond quickly to customer needs and provide timely technical support and professional consultation.

Our workflow

• Customer demand analysis and project planning
• Formulation design
• Surface modification and functionalization
• Performance test
• Optimization and adjustment
• Preclinical research support
• Scale production consulting

BOC Sciences offers a full range of process services from prescription screening to formulation characterization, including nanoparticle preparation, particle size, nanoparticle modification, and encapsulation rate testing of nanomaterials. This service allows customers to simplify processes, save time and costs, and provide high-quality data analysis and technical support.

FAQ

1. What types of nanoparticle formulations do you offer?

We offer a variety of nanoparticle formulations, including lipid nanoparticle, polymer nanoparticle, mixed nanoparticle. We also offer nanocrystals, nanoemulsions, nanogels and other nanomaterials for pharmaceutical formulation, tailored for specific therapeutic and diagnostic applications.

2. Can you modify nanoparticles to carry specific drugs or biomolecules?

Yes, we specialize in customizing nanoparticles for drug delivery, including the encapsulation of a wide range of drugs and biomolecules. We also offer surface modification services to enhance targeting and stability.

3. What industries can benefit from your nanoparticle modification services?

Our services are suitable for pharmaceutical companies, biotechnology firms, academic research institutions, and healthcare organizations focused on drug delivery, diagnostics, imaging, and therapeutic development.

4. What is the typical process for developing a custom nanoparticle formulation?

The development process typically involves initial consultation to understand your requirements, followed by formulation development, characterization, optimization, and final product testing. We also offer continuous support and iterative development.

5. How do you ensure the quality and consistency of your nanoparticle formulations?

We adhere to stringent quality control protocols, using advanced characterization techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), and high-performance liquid chromatography (HPLC) to ensure consistency and efficacy.

6. What is your lead time for developing and delivering custom nanoparticle formulations?

Lead times can vary depending on the complexity of the formulation and specific project requirements. Generally, the process can take anywhere from a few weeks to several months.

7. Do you offer scalability options for nanoparticle formulations from research to commercial production?

Absolutely, we provide scalable solutions to take your formulation from the research stage to commercial-scale production, ensuring that the transition is seamless and cost-effective.