Spray Formulation Development Services

As a biopharmaceutical company focused on the development of pharmaceutical formulations, we understand the importance of spray formulation in enhancing drug absorption efficiency and improving the patient medication experience. For this reason, BOC Sciences offers comprehensive and efficient spray formulation research and development services, aiming to provide customers with a full range of solutions from concept design to commercial production.

What is a spray?

Sprays are preparations in which the contents are sprayed in a mist or other form by the pressure of a hand pump or by other means without a projectile. The power to spray the liquid is the pressure of a hand pump or compressed gas in the container, without the need for a projectile.

Types of spray

• Classification by dispersion system: solution spray, emulsion spray, suspension spray.
• Classification according to the dosage: quantitative spray, non-quantitative spray.
• According to the route of administration classification: inhalation spray, skin administration spray, nasal spray,oral spray.

Advantages of sprays

• Easy to use, does not contain ejector, can avoid air pollution; The side effects and irritants of the projectile on the body are reduced.
• Simple prescription, simple production equipment, low cost, high production safety.
• There is no need for prepressure, and only a small touch force can reach the required pressure of spray
• Wide range of application, that is, suitable for local administration, but also can produce systemic effects.

Comprehensive spray formulation services

Inhalation spray development

For respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), we provide a full range of services from drug screening and formulation optimization to production process development. Advanced spray drying technology, micronization technology and drug-device matching research are used to ensure that drug particles are moderate in size and uniform in distribution, so as to achieve effective deposition of drugs in the lungs and improve the therapeutic effect. A comprehensive assessment of aerosol properties, including fine particle fraction (FPF), aerodynamic median mass diameter (MMAD) and emission dose tests, was performed. At the same time, the convenience and comfort of operation are improved by optimizing the design of the spray device.

Nasal spray formulation development

As a fast channel for drugs to enter the brain directly, nasal cavity has a unique therapeutic advantage for central nervous system diseases and allergic rhinitis. BOC Sciences focuses on formulation optimization of nasal sprays to ensure rapid dissolution and absorption of drugs in the nasal cavity while reducing nasal irritation and discomfort. High-speed imaging and laser-based technology are used to analyze spray patterns and plume features to ensure optimal deposition in the nasal cavity. In addition, we provide nasal mucosal permeability studies and drug stability assessments to ensure product safety and efficacy.

Topical spray formulation development

Developed a range of topical sprays for skin diseases, pain management and other areas. By precisely controlling the speed of drug release and the depth of penetration, accurate treatment of local diseased areas is achieved. Our services include active ingredient screening, formulation design, skin irritation testing, skin penetration properties testing and pharmacodynamic evaluation to ensure that products are effective in relieving symptoms while minimizing side effects.

Oral spray formulation development

As a new drug delivery method, oral spray can quickly deliver drugs to the mouth or throat in the form of mist, and quickly absorb into the blood circulation, which is suitable for emergency medicine, children's medicine and patients with dysphagia. BOC Sciences is dedicated to the research of rapid dissolution technology, taste improvement and stability of oral sprays. Develop palatable formulations of bitter APIs with effective masking strategies to ensure that the drug remains active while enhancing patient acceptance and treatment experience. Simultaneous in vitro studies were conducted to evaluate the absorption kinetics and bioavailability of oral spray formulations.

Our service process

• Demand analysis
• Pre-formulation study
• Drug formulation development
• Process optimization
• Analytical method development and validation
• Stability study
• Device compatibility studies
• Technology transfer
• GMP production and quality control

Advanced technology and equipment capability

Micronization technique: Using advanced spray drying, supercritical fluid extraction and other fine particle technology, precise control of drug particle size, improve drug dispersion and bioavailability. These technologies are not only suitable for inhalation sprays, but are also widely used in the development of nasal sprays and topical sprays.

Spray device design and testing: We have a professional spray device research and development team, which can customize the spray device according to the drug characteristics and treatment needs. CFD (computational fluid dynamics) simulation, ergonomic testing and patient preference research ensure that the device is easy to operate and comfortable, while meeting the requirements of drug delivery efficiency.

3D printing technology: The use of 3D printing technology to manufacture personalized drug spray devices to improve the patient experience.

Why choose BOC Sciences?

• Experienced professional team
• One-stop R&D service
• Efficient formulation development process
• Customized solutions to meet individual needs
• Strict quality control system, in accordance with international GMP standards and ICH guidelines

FAQ

1. What is the process for developing a spray formulation?

• Initial consultation: Understanding client requirements and therapeutic goals.
• Formulation design: Developing and optimizing the spray formulation.
• Analytical method development: Creating methods to evaluate spray performance and stability.
• Device compatibility testing: Ensuring the formulation works with the chosen delivery device.
• Regulatory support: Preparing necessary documentation for regulatory approval.
• Scale-up and manufacturing: Pilot and commercial-scale production of the spray formulation.

2. How do you ensure the stability of spray formulations?

We conduct comprehensive stability testing under various environmental conditions to ensure the formulation remains effective over its intended shelf life. This includes physical, chemical, and microbiological stability assessments.

3. Can you develop formulations for both liquid and powder sprays?

Yes, we develop both liquid and powder spray formulations suitable for various therapeutic applications. Our expertise includes selecting the appropriate solvents, propellants, and excipients to ensure stability and performance.

4. How do you ensure device compatibility for spray formulations?

We conduct extensive device compatibility testing to ensure our formulations work effectively with various delivery devices, such as MDIs, DPIs, nasal spray devices, topical spray applicators, and oral spray dispensers. We evaluate performance metrics like dose accuracy, reproducibility, and user experience.

5. How do you ensure the quality and consistency of spray formulations during manufacturing?

We adhere to stringent quality control standards and GMP guidelines throughout the scale-up and manufacturing process. Our facilities are equipped for both pilot-scale and commercial-scale production, ensuring scalability and consistency in the final product.

6. How can I get started with my spray formulation project?

To get started with your spray formulation project, please contact us to schedule an initial consultation. Our team will work with you to understand your specific requirements and therapeutic goals, and provide a customized plan to develop your spray formulation from concept to commercialization.