Hyaluronic Acid Quality Control Testing
The professional team at BOC Sciences utilizes an advanced analytical platform to deliver superior quality control testing services for hyaluronic acid (sodium hyaluronate). Our combination of deep industry experience with cutting-edge analytical technologies enables us to validate hyaluronic acid products against industry standards and regulatory requirements. We perform comprehensive hyaluronic acid testing through evaluation of its physicochemical properties together with structural characterization as well as purity and stability assessments to deliver complete quality evaluations for clients working in pharmaceuticals, cosmetics, and biomaterials industries. Our testing solutions deliver precise results for both raw and cross-linked hyaluronic acid products, helping clients maintain quality standards and product safety.
What is Hyaluronic Acid Testing?
Hyaluronic acid (HA) is a biopolymer widely used in the biopharmaceutical, cosmetic, tissue engineering, and food industries. Due to its high water absorption, biocompatibility, and tunable physicochemical properties, HA has broad applications in medical fillers, lubricants, drug delivery carriers, and cosmetics. However, the molecular weight, purity, crosslinking degree, and other physicochemical properties of HA directly affect the performance and safety of its final products. Therefore, the quality control testing of HA is crucial not only to ensure that products meet quality standards but also to effectively control their functional characteristics in different applications. Through precise quality testing and characterization, companies can optimize production processes, improve product stability, reduce batch-to-batch variation, and meet the stringent requirements of regulatory authorities, ensuring the safety and efficacy of HA products.
Advantages of BOC Sciences in Hyaluronic Acid Analysis
Advanced Analytical Platform
Equipped with high-precision analytical instruments to ensure the reliability and repeatability of test results.
Comprehensive Testing Items
Covers key quality parameters of HA, including structure, purity, impurities, and stability.
State-of-the-Art Equipment
Utilizes advanced technologies such as high-performance liquid chromatography, gas chromatography, and dynamic light scattering.
Customized Services
Develops bespoke analytical methods based on client needs to meet the requirements of different application scenarios.
Rich Industry Experience
Accumulated extensive HA testing experience in the biopharmaceutical, cosmetics, and medical device industries.
Efficient and Rapid Delivery
Provides efficient testing solutions to ensure the fast delivery of reliable data.
Strict Quality Management System
Implements an ISO-certified quality management system to ensure data accuracy and traceability.
Technical Support and Consultation
Provides professional technical support to help clients optimize product development and manufacturing processes.
Hyaluronic Acid Testing Services by BOC Sciences
With our advanced analytical platform and professional technical team, BOC Sciences offers comprehensive HA testing services, covering key indicators such as physicochemical properties, molecular structure, purity, impurities, microbial safety, and stability. We strictly follow international quality standards and regulatory requirements to ensure that products meet industry standards, helping clients optimize the research and development, production, and quality management of HA products.
Appearance and Form Evaluation
Assesses the color, form, and solubility of hyaluronic acid to ensure it meets standards.
Molecular Weight Testing
Measures the molecular weight and distribution of hyaluronic acid using gel permeation chromatography (GPC).
Purity and Concentration Testing
Determines the purity and concentration of hyaluronic acid using high-performance liquid chromatography (HPLC).
Crosslinking Agent Testing
Detects residual crosslinking agents in hyaluronic acid, such as BDDE, DVS, or EDC/NHS.
Solubility Testing
Measures the solubility of hyaluronic acid in different solvents to optimize formulations.
Moisture Testing
Determines the moisture content of hyaluronic acid using Karl Fischer titration.
Endotoxin Testing
Tests the endotoxin levels in hyaluronic acid products using the Limulus Amebocyte Lysate (LAL) assay.
Microbial Limits Testing
Evaluates microbial contamination in hyaluronic acid samples.
Impurity Testing
Analyzes organic volatile impurities, protein content, residual chemicals, or degradation products.
Additive Testing
Detects additives such as stabilizers and buffers in hyaluronic acid products.
Structural Identification
Identifies the structure of hyaluronic acid using nuclear magnetic resonance and Fourier-transform infrared spectroscopy.
Heavy Metal Testing
Analyzes the levels of heavy metals such as lead, mercury, arsenic, and cadmium in hyaluronic acid.
Residual Solvent Testing
Detects solvent residues used during production.
In Vitro Degradation Testing
Evaluates the degradation rate of hyaluronic acid in in vitro environments.
Stability Testing
Assesses the stability of hyaluronic acid under various temperature and humidity conditions.
Osmotic Pressure Testing
Determines the osmotic pressure of hyaluronic acid solutions to ensure compatibility with biological systems.
Viscosity Testing
Measures the viscosity of hyaluronic acid solutions to evaluate their rheological properties.
Particle Size Testing
Analyzes the particle size distribution of hyaluronic acid microspheres or gels.
Rheological Testing
Studies the shear thinning behavior of hyaluronic acid to optimize its performance in applications.
Shear Rheology Testing
Measures the rheological properties of hyaluronic acid at different shear rates.
Coefficient of Friction Testing
Evaluates the performance of hyaluronic acid in joint lubrication and soft tissue repair.
Crosslinking Degree Testing
Analyzes the density of the crosslinking network in hyaluronic acid and its impact.
Surface Adhesion Testing
Assesses the adhesive properties of hyaluronic acid on different substrates.
Half-Life Testing
Determines the degradation rate of hyaluronic acid in physiological environments.
Compatibility Testing
Evaluates the compatibility of hyaluronic acid with other biomaterials.
What Types of Hyaluronic Acid Tests Do We Support?
BOC Sciences, with its advanced analytical platform and professional technical team, offers comprehensive quality testing and method development services for various types of HA products, ensuring compliance with industry standards and regulatory requirements. Our testing services cover the entire product chain, from raw materials to final products, helping customers optimize product performance and enhance market competitiveness.
Hyaluronic Acid Raw Materials
HA raw materials are the fundamental components for preparing various HA products, typically available in powder or solution form. BOC Sciences provides key quality assessments such as molecular weight determination, purity analysis, and impurity testing, ensuring that the raw materials meet pharmaceutical and cosmetic industry standards.
Crosslinked Hyaluronic Acid
Crosslinked HA enhances stability and durability through chemical modification and is widely used in medical and cosmetic fillers. BOC Sciences offers crosslinking degree determination, residual crosslinking agent analysis, and mechanical performance testing to ensure the safety and effectiveness of crosslinked HA.
Hyaluronic Acid Formulations
HA formulations contain multiple components such as antioxidants, vitamins, minerals, and are commonly used in skincare and medical aesthetics. BOC Sciences provides formulation stability testing, additive analysis, pH measurement, and osmotic pressure determination to ensure the stability of the product performance and compliance with market demand.
Hyaluronic Acid Gel
HA gel, known for its excellent moisturizing and rheological properties, is extensively used in skincare and medical products. BOC Sciences assesses the stability and performance of HA gels through viscosity testing, rheological analysis, and pH measurement.
Hyaluronic Acid Microspheres
HA microspheres are innovative materials used for tissue filling and sustained-release formulations. BOC Sciences provides particle size distribution determination, surface charge analysis, and biodegradability testing to ensure their uniformity, stability, and biocompatibility.
Hyaluronic Acid Fillers
HA fillers are primarily used in medical aesthetics and soft tissue repair, requiring high purity and biological stability. BOC Sciences conducts purity analysis, endotoxin testing, crosslinking degree evaluation, and shear rheology testing to ensure the safety and longevity of the products.
Hyaluronic Acid Nanogels
HA nanogel is modified using nanotechnology, offering good permeability and biocompatibility. The testing services provided by BOC Sciences include particle size distribution, viscosity testing, stability testing, and drug loading analysis to ensure product quality and performance.
Hyaluronic Acid Nanoparticles
HA nanoparticles enhance drug delivery through nanotechnology and are commonly used in targeted therapy and sustained-release drug delivery. BOC Sciences offers testing services such as particle size measurement, encapsulation efficiency testing, stability evaluation, and biodegradability analysis to ensure the reliability of the nanoparticles.
Hyaluronic Acid Analysis Method Development Services Offered by BOC Sciences
To meet diverse application needs, BOC Sciences provides comprehensive HA analysis method development services to ensure product compliance with industry standards and regulatory requirements. Our experienced team of analytical scientists uses advanced analytical instruments to develop highly sensitive and specific analysis methods for customers. Our services cover key parameters such as molecular weight determination, purity analysis, crosslinking degree assessment, degradation product characterization, heavy metal testing, and residual solvent analysis. Furthermore, we optimize the sensitivity, accuracy, and repeatability of analysis methods based on customer needs and provide method validation services to ensure the reliability and reproducibility of the methods. BOC Sciences is committed to providing high-quality HA analytical solutions, assisting customers in product development, quality control, and market compliance.
Comprehensive Quality Control Platform from BOC Sciences
Our analytical laboratories are equipped with high-precision testing instruments, covering physicochemical analysis, structural characterization, impurity analysis, rheological testing, and biocompatibility assessment, ensuring the quality, safety, and compliance of HA products. Our testing platform strictly adheres to international regulatory requirements, and all tests provide comprehensive analysis certificates (CoA), ensuring that HA products meet relevant regulations and industry standards. Our testing methods are based on standards from USP, EP, JP, and are applicable for quality assessments in various application scenarios. Below are our core analytical instruments:
High-Performance Liquid Chromatography (HPLC) Gel Permeation Chromatography (GPC) Gas Chromatography (GC) Mass Spectrometry (MS) Nuclear Magnetic Resonance (NMR) Fourier-Transform Infrared Spectroscopy (FTIR) Ultraviolet-Visible Spectrophotometer (UV-Vis) Dynamic Light Scattering (DLS) Rheometer Osmometer Endotoxin Detection System Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
Service Workflow
What Applications Do Our Hyaluronic Acid Testing Services Support?
HA is widely used in various fields such as pharmaceuticals, medical devices, cosmetics, skincare, food supplements, and biomaterials due to its excellent moisturizing, biocompatibility, and lubricating properties. Different applications require different quality standards for HA, involving parameters such as molecular weight, purity, structural stability, and biocompatibility. BOC Sciences, with its advanced testing platform and professional analysis team, offers comprehensive quality testing and method development services for HA products tailored to different applications, ensuring they meet international regulations and industry standards. Through precise analytical techniques, we help customers optimize product performance, enhance market competitiveness, and ensure the best results for HA in various applications.
Pharmaceutical Industry
HA is widely used in ophthalmic surgical viscosupplements, osteoarthritis injection formulations, and drug delivery carriers.
Medical Devices
HA is used in medical devices such as wound dressings, surgical implants, and biomedical films.
Aesthetic Medicine and Fillers
HA fillers are widely used in aesthetic medicine for skin filling, wrinkle repair, and facial contouring.
Skincare and Cosmetics
Due to its excellent moisturizing properties, HA is widely used in skincare products such as moisturizers, creams, and serums.
Food and Supplements
As a nutritional supplement, HA is used in oral liquids, capsules, and functional foods to promote joint health and skin moisture retention.
Biomaterials and Tissue Engineering
HA is used in biomaterials and tissue engineering, such as cell culture scaffolds, tissue repair, and bioprinting materials.
Ophthalmic Applications
HA is widely used in ophthalmic surgeries such as cataract surgery viscosupplements, eye drops, and contact lens lubricants.
Drug Delivery Systems
As a key material in nanomedicine or controlled-release systems, HA can improve drug solubility and targeting.
FAQs
What are the properties of hyaluronic acid?
Hyaluronic acid has various unique physicochemical properties, including high hydration, good biocompatibility, viscoelasticity, and biodegradability. It can absorb and retain large amounts of water, keeping the skin moist, which is why it is widely used in moisturizing skincare products. The high molecular weight of hyaluronic acid provides strong viscoelasticity, making it important for joint lubrication and ophthalmic surgeries. It also has good biodegradability and low immunogenicity, making it an ideal choice for medical and biomaterial applications.
What is the method of analysis of hyaluronic acid?
Analytical methods for hyaluronic acid include high-performance liquid chromatography (HPLC), UV spectroscopy, and gel permeation chromatography (GPC). These methods can be used to analyze the molecular weight, purity, and concentration of hyaluronic acid, helping confirm its quality and functionality in different applications. The choice of method depends on the testing requirements and specific characteristics of the hyaluronic acid.
What is the Elisa test for hyaluronic acid?
The ELISA test for hyaluronic acid is an enzyme-linked immunosorbent assay that uses specific anti-hyaluronic acid antibodies to detect the concentration of hyaluronic acid through an enzymatic reaction. This method is efficient and sensitive and is widely used for quantitative detection of hyaluronic acid in biological samples, making it suitable for medical research and clinical applications.
What is the characterization of hyaluronic acid?
Characterization of hyaluronic acid typically includes analysis of molecular weight distribution, purity, solubility, crosslinking degree, and structural features. Molecular weight distribution is an important characteristic of hyaluronic acid and is usually analyzed by gel permeation chromatography (GPC). Its purity can be confirmed by high-performance liquid chromatography (HPLC) and UV spectroscopy. Additionally, its hydration ability, viscosity, and stability under different pH and temperature conditions are key characterization parameters. These characteristics collectively determine the performance of hyaluronic acid in various applications, especially in pharmaceuticals, cosmetics, and biomedical fields.