Peptide Formulation Development
BOC Sciences specializes in providing professional peptide formulation development services for the medical aesthetics, cosmetics, and biopharmaceutical fields, with comprehensive research and development capabilities ranging from molecular design and structural optimization to final product formulation. Supported by a strong peptide synthesis platform and advanced carrier technologies (such as liposomes, microemulsions, microneedles, etc.), we can offer personalized solutions with high stability and permeability for various application scenarios. Our advantages include extensive experience in peptide structural modification, strong formulation compatibility, a complete efficacy validation system, and comprehensive regulatory compliance support, enabling efficient project development from concept to product, helping clients stand out in the competitive market.
Key Peptide Formulation Challenges Addressed by BOC Sciences
Poor peptide stability, easy degradation
Peptides have highly active molecular structures that are prone to enzymatic degradation, oxidation, light exposure, or temperature sensitivity, leading to inactivation. BOC Sciences provides modification, encapsulation, and anti-degradation processes to enhance peptide storage stability and shelf life.
Low transdermal absorption, limited bioavailability
Due to their large molecular weight and strong polarity, peptides are difficult to penetrate the skin barrier. We use carrier encapsulation, permeation enhancers, and structural optimization technologies to improve their permeability and biological efficacy in topical products.
Difficulty in precisely controlling pH and osmotic pressure
Peptide formulations often need to function under physiological conditions and are sensitive to pH and osmotic pressure. BOC Sciences optimizes buffering systems and solution components to ensure product comfort and stability during use.
Poor compatibility with other ingredients, prone to adverse reactions
Peptides may react with certain active ingredients or excipients, affecting their efficacy or safety. We offer systematic compatibility studies, screening for compatible ingredients to ensure the formulation functions synergistically and remains stable and safe.
Difficult to control release behavior, inability to achieve targeted effects
Peptide formulations often require sustained release or specific site-targeted release. BOC Sciences provides controlled release technologies such as liposomes, nanoparticles, and microspheres to achieve targeted release in the skin or tissues.
Lack of standardized quality evaluation methods and instrument support
Peptide formulations are complex to detect and require professional methodologies. BOC Sciences is equipped with advanced analytical instruments and established testing methods to ensure each product undergoes systematic quality validation and regulatory compliance.
Peptide Formulation Development Services
BOC Sciences is dedicated to providing clients with efficient, systematic, and customized peptide formulation development services covering the entire chain from molecular screening to final application, particularly for medical aesthetics, functional cosmetics, and biomedical applications. Our service system is closely aligned with industry needs, helping clients shorten product development cycles, enhance product stability, and improve market competitiveness. Major services include:
Peptide Screening and Custom Design
Based on client product positioning and functional requirements (such as anti-wrinkle, repair, antioxidant), BOC Sciences offers rapid screening from an existing peptide library or conducts structural design for novel functional peptides. Using AI-assisted modeling and database resources, we help clients select the most application-potential peptide sequences, considering synthesis difficulty, permeability, and biological stability.
Peptide Modification and Structural Optimization
To address the issues of poor stability and easy degradation of natural peptides, we offer various modification methods, including N/C-terminal capping, amino acid site substitution, D-amino acid introduction, cyclization, or fatty acid conjugation, enhancing peptide stability, biological activity, and membrane permeability, improving compatibility in cosmetic and medical aesthetic applications.
Peptide Stability Assessment and Enhancement
Stability is a core indicator in peptide formulation development. BOC Sciences conducts stability testing under various environmental conditions (temperature, pH, light, oxidation, etc.), combining formulation strategies such as sustained release carriers, antioxidant additives, and freeze-drying protection to significantly improve the peptide's storage period and biological activity retention in actual products.
Transdermal Permeation System Development
To address the issue of low peptide permeability, BOC Sciences develops various delivery systems such as peptide liposome encapsulation, nanoemulsion technology, polymer microsphere carriers, and hyaluronic acid microneedle arrays to increase skin absorption and targeted delivery efficiency, especially suitable for high-end functional skincare products and post-procedure medical aesthetic products.
Compound Mechanism Research
Based on skin physiology and pharmacological mechanisms, we design and verify the synergistic effects of peptides with other active ingredients (such as vitamin C, vitamin B3, ceramides, hyaluronic acid, CoQ10, etc.). Through systematic in vitro and cellular experiments, we screen the optimal compound ratios to enhance the product's multi-functional efficacy.
Prototype Formulation Design
Based on client needs and market trends, we develop various prototype formulations, including peptide serums, repair masks, injectable formulations, gels, sprays, etc. Formulation development focuses on stability, permeability, skin feel, and efficacy validation, with customized formulations available for different skin types or pathological conditions.
Efficacy Validation and Stability Testing
We provide scientifically rigorous in vitro experiments and simulated application scenario testing services, including anti-wrinkle models, collagen synthesis models, cell migration repair models, antioxidant capacity testing, and permeation curve analysis. Stability accelerated tests are conducted in accordance with international standards to evaluate the formulation's performance during transportation, storage, and use.
GMP Manufacturing Capabilities for Peptide Formulation
BOC Sciences has GMP production facilities that meet international standards, providing strong manufacturing support for the industrialization of peptides and their formulations. Our GMP platform covers the entire production process from small scale to pilot and commercial scale, equipped with clean rooms, automated filling systems, sterile testing areas, and strict environmental control systems to ensure peptides are produced under stable, controlled conditions. The manufacturing process strictly adheres to relevant regulations from ICH, FDA, and EMA, with key parameters such as temperature, pH, stirring speed, and sterilization processes digitally monitored and batch-recorded. BOC Sciences can undertake GMP production of liquid, lyophilized powder, microemulsions, gels, and other peptide formulations, helping clients accelerate the transition from R&D to clinical sample preparation and commercialization, providing stable, high-quality industrial support for peptides in the medical aesthetics, cosmetics, and biomedical industries.
Integrated Platform for Performance Characterization and Quality Testing
BOC Sciences has established a specialized integrated quality inspection platform dedicated to the performance characterization and quality evaluation of peptide formulations. Aware of the high sensitivity of peptide formulations in terms of stability, bioactivity, structural integrity, and release characteristics, we are equipped with a comprehensive analytical system and world-class testing instruments. This ensures that every stage of formulation development is subject to precise and controllable quality supervision. Our testing services cover multiple dimensions, including raw material analysis, formulation properties, impurity control, and release behavior, providing high-quality and reliable data support for R&D, preclinical studies, and GMP production, thereby accelerating the regulatory approval and market entry of peptide products.
Testing Items
Peptide purity analysis Molecular weight determination Chemical structure identification Particle size and distribution analysis Surface charge (Zeta potential) analysis Peptide content determination Microbial limit and sterility testing Stability testing (light, temperature, and humidity) pH and osmolality testing In vitro release behavior evaluationAnalytical Instruments
High-Performance Liquid Chromatography (HPLC) Mass Spectrometer (MS) Nuclear Magnetic Resonance Spectrometer (NMR) Dynamic Light Scattering Instrument (DLS) Zeta Potential Analyzer UV-Visible Spectrophotometer (UV-Vis) Sterility Testing System Stability Testing Chamber (ICH conditions) Electrochemical Analyzer (pH/osmolality) Franz Diffusion Cell System
Peptide Formulation Applications: Empowering Medical Aesthetics and Cosmetics Brands
With the integration of biotechnology and precision skincare concepts, peptides, as efficient, safe, and multifunctional active ingredients, are playing an increasingly central role in the fields of medical aesthetics and cosmetics. Their unique biological regulation properties make them widely used in high-end skincare products for anti-aging, repair, whitening, sensitivity relief, and firming. BOC Sciences possesses a strong background in peptide chemistry and formulation technology platforms, providing customized peptide design, formulation development, and industrialization solutions to meet brands' needs for high-performance, differentiated skincare products, helping customers stand out in a competitive market.
Peptide Serums
Serums are the most common form of peptides in functional skincare products, characterized by high permeability, high activity, and a refreshing skin feel. BOC Sciences' peptide serums can carry a variety of functional ingredients such as anti-wrinkle peptides, repair peptides, and whitening peptides, suitable for daily care and post-surgical recovery products. Their stability and absorption properties are optimized and verified.
Peptide Masks
Mask products serve as an efficient delivery vehicle for peptides, enhancing penetration efficiency by creating a closed environment. We offer formulation designs using various substrate materials (e.g., non-woven fabric, hydrogel, silk membrane fabric, etc.), widely used in skin repair, hydration, soothing, firming, and wrinkle reduction masks, suitable for rapid effect beauty treatments.
Peptide Injectables
For medical aesthetics scenarios such as hydra-injections, thread lifting post-surgery recovery, and inflammation control, BOC Sciences develops high-purity, sterile, and stable peptide injectable prototypes. These formulations have strict requirements for pH, osmotic pressure, and buffer systems, compatible with synergistic components like hyaluronic acid and amino acids, balancing biocompatibility and pharmacological activity.
Peptide Gels
Gel formulations are ideal for post-surgical calming, localized repair, acne scar reduction, and other functional needs. BOC Sciences' peptide gel formulations form a membrane quickly, release active ingredients in a controlled manner, and provide a good skin feel and suitability. These are commonly used in post-surgery care at medical aesthetic clinics, sensitive skin product lines, and lightweight medical aesthetics brands.
Peptide Sprays
Peptide spray formulations are convenient for carrying and quickly replenishing active ingredients, suitable for daily anti-aging protection and emergency skin care. Through micro-nano emulsification technology and peptide stabilizer formulations, BOC Sciences has achieved stable, room-temperature peptide sprays, adaptable for use on the face, body, and scalp.
Peptide Lotions
In daily skincare routines, lotions and creams, as highly occlusive carriers, help extend the active release of peptides on the skin's surface. BOC Sciences provides collaborative stabilization strategies for peptides with lipid-phase systems, ensuring uniform distribution and controlled release of anti-aging, whitening, and repair peptides in oil-in-water or water-in-oil systems.
Biomedicine
In the field of biomedicine, peptide formulations are primarily used for targeted drug delivery by optimizing the selectivity and stability of peptides, improving the ability of drugs to penetrate target cells and enhancing therapeutic effects. These are widely used in the treatment of cancers, immune system diseases, and more.
Vaccine Adjuvants
In vaccine development, peptide formulations as immune adjuvants can enhance the immunogenicity of vaccines and improve the immune response levels. For instance, antigenic peptides stimulate T-cell or B-cell immune responses to strengthen humoral or cell-mediated immunity, applied in the development of COVID-19 vaccines, cancer vaccines, and flu vaccines.
FAQs
What are peptides in cosmetics?
Peptides are short chains of amino acids that can penetrate the skin and support its natural repair processes. In cosmetics, peptides help stimulate collagen production, improve skin elasticity, reduce wrinkles, and enhance hydration, leading to smoother, firmer skin.
How are peptides formulated in cosmetic products?
Peptides are incorporated into cosmetics through various delivery systems like serums, creams, and masks. These formulations ensure that peptides are stable, bioavailable, and can effectively target deeper layers of the skin to achieve desired results.
How is the quality of peptide formulations in cosmetics ensured?
At BOC Sciences, we use advanced synthesis techniques, strict quality control processes, and comprehensive stability testing to ensure the purity, efficacy, and safety of peptide formulations. Our products comply with industry standards, ensuring consistent performance in cosmetic applications.
Can peptide formulations be customized according to specific cosmetic needs?
Yes, BOC Sciences offers customized peptide synthesis and formulation services to meet clients' unique needs. We work closely with customers to create peptide formulations tailored to specific skincare demands (e.g., anti-aging, brightening, or skin repair), providing precise and effective solutions.