Protein and Peptide Drug Formulation Development
Protein and peptide drugs have been widely used in drug research and development because of their strong pharmacological activity, high specificity and low toxicity. It plays an irreplaceable role in the fields of anti-tumor, anti-virus, treatment of cardiovascular diseases and autoimmune defects. BOC Sciences is committed to providing its customers with cutting-edge peptide and protein drug formulation development services to accelerate research and development, optimize product performance and ensure market success.
What are peptide drugs and protein drugs?
Peptide drugs are often formed by dehydration of 10 to 100 amino acid molecules and then separated and purified. More than 100 amino acids can form a protein. The main difference between a peptide and a protein is the difference in the length of the peptide chain. Compared with small molecule drugs, protein peptide drugs have the advantage of having stronger specificity and fewer side effects, because whether they are bioengineered or chemically synthesized, their composition and metabolism are usually the same as endogenous proteins. or similar. Moreover, such drugs bind more specifically to targets, which means that they have extremely low or no binding to non-targets.
Protein and peptide drugs have poor membrane permeability and are extremely sensitive to enzymes, so these drugs have always been mainly administered by injection in clinical practice. However, the production cost of injections is high, the injection route is inconvenient to use, the cost is high, and long-term use increases the patient's mental burden greatly reduces patient compliance, and some drugs also have side effects. However, it has been reported that side effects of such drugs are usually caused by large doses at the injection site and are usually local adverse reactions. Based on this, pharmaceutical workers have been committed to finding non-injectable routes for new protein and peptide drugs that are more acceptable to patients and have less toxic and side effects, including pulmonary, nasal, oral, intraocular, transdermal, rectal and oral administration.
Protein and peptide drug formulation services
Pre-formulation for protein and peptide drug
BOC Sciences begins with the characterization of the chemical and physical properties of proteins or peptides. This includes determining key parameters such as molecular weight, isoelectric point, solubility, and stability of a protein or peptide. Conduct stability studies to evaluate the degradation of protein and peptide drugs under different temperature, humidity and light conditions. Select appropriate buffers, pH regulators and stabilizers to improve drug stability and bioavailability.
Formulation development service
As specialists in pharmaceutical formulations, BOC Sciences not only provides the development of traditional protein or peptide drug injections and freeze-dried formulations, but also provides the development of new oral and mucosal drug formulations. The oral bioavailability of the drug was increased by adding absorption enhancers, enzyme inhibitors and enteric coating.
Protein and peptide drug delivery system
Nanoparticles, liposomes, microspheres and hydrogels have been studied more in the new drug delivery system of protein and peptides, which can greatly improve the stability of such drugs, prolong their half-life in vivo, reduce the number of administration times, increase the therapeutic effect, reduce the side effects of drugs, and realize the targeting and slow controlled release of protein and peptide drugs.
Protein and peptide drug characterization
Protein and peptide drug manufacturing
BOC Sciences has established a GMP-compliant preparation workshop with advanced equipment and complete functions to provide corresponding drug production services for clinical trial research.
Protein and peptide drug preclinical study
Need A Consultation on Protein and Peptide Drug Formulation Development services?
Why choose BOC Sciences?
Application of advanced nanotechnology: The use of advanced nanotechnology, including nano emulsion, liposome, nano microspheres, nanogel and other preparation technology. These technologies can effectively improve the solubility, stability and bioavailability of protein and peptide drugs, while reducing the side effects and toxicity of drugs.
Senior R & D team: composed of experienced professional researchers, according to the physical and chemical properties of protein and peptide drugs provided by customers, to provide customized protein and peptide drug preparation solutions to promote biomedical innovation.
One-stop solution: Provide end-to-end services for small molecule drugs and biologics from formulation design and optimization to scale production and regulatory filing. No matter where you are in drug development, we can support you to ensure a smooth transition to the next stage of your project.
For oral protein and peptide drugs, we use chemical absorption enhancers and enzyme inhibitors to promote drug penetration. For nasal mucosa, we have developed a highly permeable formula and microfluidic technology, which is especially suitable for the treatment of central nervous system diseases, and the drug can quickly cross the blood-brain barrier and reach the central target.
Related resources
Sustained Release Tablets Definition
Drug Delivery System for Buccal Administration
Buccal mucosa is the target site of buccal drug delivery system. These systems are designed to absorb drugs directly from mucosal surfaces into the bloodstream, avoiding first-pass effects and potential drug degradation in the digestive tract. Buccal mucosal delivery, as a non-invasive drug delivery route, is particularly suitable for the delivery of peptide and protein drugs, as well as those that are not effective orally.
What is Film Coated Tablet?
Tablets are among the most convenient and preferred oral solid dosage forms because of their many advantages. The coating can provide physical and chemical protection for the drug, and it can also alter the release of the drug. A layer of insoluble gastric fluid but easily soluble intestinal fluid coating is wrapped around ordinary tablets to realize the positioning and release of drugs in the intestine.