Nano Formulation Development Service

In the rapid development of biopharmaceutical field, BOC Sciences stands at the forefront of the industry innovation, providing cutting-edge nano formulation development service platform, designed to meet the diversified needs of modern drug development. With our deep expertise in nanotechnology and pharmaceutical science, our platform provides comprehensive and precise solutions for the development and optimization of nano formulations. This includes the subtle use of nanoparticles, liposomes, nanoemulsions, nanogel, dendrimers and other cutting-edge nanocarriers.

What are nanoparticles?

Nanomaterials are defined as particles that have at least one dimension ≤100 nm in a three-dimensional space. Nanoparticles are comparable in size to biological entities such as proteins, and similar in size to viruses, DNA, and other cellular components. Nanoparticles have a high surface-area-to-volume ratio, which allows them to hold many substances on their surface.

Types of nanoparticles and their applications

Lipid nanoparticles (LNPs): They show extraordinary potential in mRNA vaccines and gene therapy, ushering in a new era of precision medicine.

Polymer nanoparticles: Suitable for the continuous release and targeted delivery of drugs to achieve the vision of precision medicine.

Solid lipid nanoparticles: Optimize drug release rate and improve preparation stability.

Metal nanoparticles: Application in imaging and diagnostic technology, opening a new era of diagnosis and treatment.

Inorganic nanoparticles: Widely involved in the field of treatment and diagnosis, expanding the boundary of medical applications.

Advantages of nano formulation

Nano formulations, which are carefully designed and developed nanoscale drug delivery systems ranging in size from 1 to 100 nanometers, offer significant advantages over traditional drug delivery methods:

Targeted delivery: Nanoparticles can be precisely targeted to specific cells or tissues, greatly reducing non-targeted effects and improving the safety and effectiveness of therapy.

Enhanced bioavailability: Nano formulations can significantly improve the solubility and stability of insoluble drugs, ensure the efficient absorption and utilization of drugs, and enhance the therapeutic effect. The nanoscale structure promotes the penetration of drugs across biofilms and improves their efficacy.

Controlled release: Nanoparticles are designed to deliver drugs on demand, ensuring consistent and stable therapeutic concentrations, reducing the frequency of dosing, and improving patient compliance.

Stability guarantee: Effectively protect the drug from the internal environment, avoid early degradation, prolong the drug activity cycle, and ensure lasting efficacy.

Multi-functional integration: Compatible with various therapeutic ingredients, such as small molecules, peptides, proteins and nucleic acids, becoming an all-round platform for drug development.

Our nano formulation services

Feasibility study and pre-formulation exploration

At the beginning of each project, we launch an in-depth feasibility study to fully evaluate the suitability of nanoparticle delivery systems for specific drug candidates. In the pre-formulation stage, we carefully analyze the physical and chemical properties, solubility improvement and stability evaluation, laying a solid foundation for the subsequent formulation development.

Ingenious design and optimization of nanoparticles

Relying on cutting-edge technologies such as nanoprecipitation, emulsification and spray drying, our team of experts carefully design nanoparticles to ensure that their size, shape and surface properties are accurate. By fine-tuning the formulation parameters, we achieve the ideal drug load, release curve and stability, creating the perfect vehicle for drug delivery.

Packaging technology

We offer a wide range of packaging solutions, including polymer nanoparticles, lipid nanoparticles and solid lipid nanoparticles, providing a full range of options for the packaging of small molecules, peptides, proteins and even nucleic acids. This series of platforms ensures optimal protection of active ingredients for precise delivery.

Nanoparticle analysis and verification services

Particle size and morphology analysis: Dynamic light scattering (DLS) and transmission electron microscopy (TEM) are used to accurately determine particle size distribution and morphological characteristics.

Surface charge measurement: Evaluate the surface charge state of nanoparticles by electrokinetic potentiometry, which has a direct impact on stability and cell uptake.

Drug loading and encapsulation efficiency quantification: Accurate calculation of the drug content inside the nanoparticle and the efficiency of the encapsulation process.

Evaluation of drug release kinetics in vitro: Conduct in vitro release tests to gain insight into the rate and pattern of drug release from nanoparticles.

Customized production of nanoparticles

The transition from lab-scale development to large-scale production is a critical phase in nanoparticle formulation development. Our custom nanoparticle manufacturing services provide scalable solutions tailored to our clients' production needs. Utilizing state-of-the-art manufacturing facilities and stringent quality control protocols, we ensure that each batch of nanoparticles is produced with consistent quality, meeting regulatory requirements.

Our services including the following:

• Lipid nanoparticle development services
• Polymer nanoparticles development services
• Nanoemulsion formulation services
• Nanogel drug delivery system development
• Nanocrystal research and development
• Nanobody drug delivery system development services
• Protein-based nanoparticle drug delivery system development
• Nanoparticle drug delivery system modification
• Nano formulation analysis and verification
• Nano preparation production services

Advantages of nano formulation services

Application of advanced nanotechnology: The use of advanced nanotechnology, including nano emulsion, nano liposomes, nano microspheres, nanogel and other preparation technology. These technologies can effectively improve the solubility, stability and bioavailability of drugs, while reducing the side effects and toxicity of drugs.

Efficient screening process: Using high-throughput screening technology to accelerate the selection of potential drugs and formulations, significantly improve research and development efficiency, shorten cycle times, and reduce costs.

Advanced experimental equipment: We have a comprehensive range of advanced instruments that play a vital role in the preparation, characterization and evaluation of nanoparticles.

Strict quality management: Follow the perfect quality management system and high standard control process, and strictly comply with the requirements of regulations to ensure the excellent quality of nano preparations and stable curative effect.

Senior research and development team: Composed of experienced and professional researchers, according to customer needs and challenges, to provide customized nano formulation solutions to promote biomedical innovation.

With excellent technical strength and unremitting pursuit, BOC Sciences is committed to transforming the infinite potential of nanotechnology into practical value and contributing to the vigorous development of the biomedical industry.

FAQ

1. What are nanoformulations?

Nanoformulations are pharmaceutical formulations that use nanoparticles to deliver active ingredients more effectively within the body. These can enhance drug solubility, stability, and bioavailability.

2. What types of nanoformulations do you develop?

We are engaged in the development of a diverse range of nanoformulations, covering the frontiers of liposomes, polymer nanoparticles, lipid nanoparticles (LNPs), nanocrystals, nanoemulsions, nanogels, and dendrimers, providing limitless possibilities for drug delivery.

3. What are the benefits of using nanoformulations?

Nanoformulations can offer several advantages such as improved drug delivery to targeted sites, reduced side effects, enhanced absorption, and sustained release properties.

4. Can you customize formulations according to specific requirements?

Yes, we offer highly customizable services to meet the specific needs and goals of each client.

5. Do you offer analytical and characterization services?

Absolutely. Our comprehensive analytical and characterization capabilities, including particle size analysis, zeta potential measurement, encapsulation efficiency evaluation, drug release curve analysis and stability testing, ensure superior formulations performance.

6. How do you ensure the quality and reproducibility of the formulations?

We adhere to rigorous quality control measures and employ advanced analytical techniques to ensure that each formulation meets the highest standards of quality and reproducibility.

7. Can you help with scale-up and manufacturing processes?

Yes, we specialize in helping customers scale up production, seamlessly connecting laboratory results to cGMP compliant industrial production, and facilitating product commercialization.

8. How can we start a partnership or project with your company?

To initiate a project, please contact us through our website or email. We will arrange an initial meeting to discuss your needs and outline the next steps.