Polylactic Acid (PLA) Services
BOC Sciences is dedicated to providing professional services for the preparation and formulation development of polylactic acid (PLA) microspheres for cutting-edge applications in biomedicine, cosmetics, and aesthetic medicine. We possess the capability for R&D and large-scale production of medical-grade, cosmetic-grade, and industrial-grade PLA microspheres, covering preparation, modification, functional surface treatment, drug delivery system construction, and development of various PLA composite formulations. Additionally, we offer customized development of PLA-based fillers to meet clinical and aesthetic application needs such as anti-aging, skin regeneration, and tissue filling. Relying on an advanced material science platform and a GMP manufacturing environment, BOC Sciences provides full-process technical support from experimental development to industrial-scale production.
Technical Advantages of BOC Sciences in PLA Services
High-Purity Raw Material Assurance
Utilizes medical-grade and cosmetic-grade PLA materials with high purity and low impurity levels to ensure biocompatibility and non-toxic degradation.
Multiscale Microsphere Preparation Capability
Capable of producing microspheres ranging from 10 nanometers to 100 micrometers, meeting requirements for injection, implantation, topical application, and more.
Advanced Surface Modification Technologies
Offers various modification options including amination, carboxylation, and PEGylation, providing microspheres with targeting and environmental responsiveness.
High Drug Loading Efficiency
Optimizes emulsification and encapsulation processes to achieve stable encapsulation and controlled release of small molecules and macromolecular actives.
Scalable GMP Production Platform
Seamlessly transitions from gram-scale R&D to kilogram-scale GMP production, enabling customers to accelerate industrial transformation.
Comprehensive Quality Testing System
Equipped with full-process testing methods for particle size, morphology, and release behavior to ensure stable and reliable product quality.
PLA Development Services by BOC Sciences
As a biodegradable and biocompatible carrier material, PLA microspheres have been widely used in recent years in controlled drug release, cosmetic injections, skin repair, and sustained-release systems for active ingredients in skincare products. With strong material science R&D capabilities and advanced microsphere preparation technologies, BOC Sciences provides end-to-end PLA microsphere development services for the biomedicine, cosmetics, and aesthetic medicine industries—from basic formulation research to commercial scale-up. Tailoring development paths based on clients' product positioning and end-use requirements, we offer precise control of parameters such as microsphere size, loaded components, release duration, and surface modification, helping clients quickly build safe, effective, and controllable product systems and accelerate the transition from laboratory to clinic or market.
PLA Microsphere Preparation
BOC Sciences is proficient in various microsphere preparation techniques, including solvent evaporation, double emulsion, and spray drying methods. We can produce microspheres with different particle sizes (10 nm to 100 μm) and morphologies (hollow, solid, porous) based on customer requirements. We support the encapsulation of various active components such as small-molecule drugs, peptides, proteins, nucleic acids, and botanical extracts, achieving precise controlled release.
PLA Microsphere Modification
To enhance the functionality and targeting capabilities of PLA microspheres, BOC Sciences offers a range of surface modification services. These include the introduction of functional groups such as carboxyl, amino, and PEG to enable binding with biomolecules, targeting ligands, or fluorescent probes, thereby improving cellular uptake efficiency, targeting capacity, or visual tracking performance. We also perform hydrophobic/hydrophilic interface adjustments to improve dispersion stability in various systems.
PLA Filler Development
For the aesthetic medicine and cosmetics industries, BOC Sciences offers customized filler development services based on PLA microspheres, suitable for high-end cosmetic applications such as skin tightening, wrinkle reduction, and depression correction. We can control microsphere size, elastic modulus, and release characteristics and blend with auxiliary materials such as hyaluronic acid and collagen to achieve both structural support and active ingredient release. All formulations can undergo stability testing and safety evaluations according to customer requirements.
PLA Formulation Development
BOC Sciences has a well-established polymer carrier formulation development platform that helps clients customize PLA formulations best suited for the release behavior of their active ingredients. Our expert team will design appropriate molecular weight, copolymer ratio, microsphere structure, and excipient systems based on the physicochemical properties of the active ingredient, the characteristics of the target site, and the desired release duration, to construct stable, safe, and high-performance microsphere formulation solutions.
GMP-Grade PLA Manufacturing Capabilities
BOC Sciences owns advanced GMP-certified manufacturing facilities and has the ability to produce PLA microspheres at laboratory scale, kilogram scale, and even larger production volumes, fully supporting customers in transitioning from early-stage development to clinical and commercial phases. Our production system strictly complies with international quality standards such as ICH and ISO, covering cleanroom environment control, raw material traceability management, batch consistency verification, and aseptic processing. To meet the high-standard requirements of the biopharmaceutical, cosmetics, and aesthetic medicine industries, we provide personalized services for process transfer, scale-up validation, stability studies, and batch customization, ensuring that each batch of products achieves industry-leading safety, uniformity, and controllability. BOC Sciences is committed to becoming a trusted GMP manufacturing partner for PLA microspheres.
PLA Quality Testing Services by BOC Sciences
During the R&D and production of PLA microspheres, comprehensive and systematic quality testing is a critical step to ensure product safety, stability, and final efficacy. BOC Sciences has established a complete PLA microsphere quality testing platform, covering full-process quality control from raw materials and formulation intermediates to final products and application scenarios. Based on different project stages, we offer one-stop testing services ranging from physicochemical characterization to biological performance verification. These services meet the regulatory and market entry requirements for pharmaceuticals, cosmetics, and medical aesthetic products in terms of quality consistency, release mechanisms, safety, and more. All testing procedures comply with GLP or GMP standards, ensuring data authenticity and traceability, and support customized reporting, regulatory compliance consultation, and technical support.
PLA Quality Control Testing
Microsphere particle size and size distribution Microsphere morphology observation Determination of encapsulation efficiency and drug loading Zeta potential testing Residual solvent detection Molecular weight and polydispersity Specific surface area and pore size measurement Water content/water activity testing
PLA In Vitro and In Vivo Testing
In vitro drug release curve Biodegradation rate In vitro cytotoxicity testing Hemolysis rate test Local injection tolerance studies in animals Histopathological analysis Fluorescence/radiotracer localization experiments In vivo pharmacokinetics research
Applications Supported by PLA Microspheres
Thanks to its excellent biodegradability, biocompatibility, and processability, PLA is emerging as a highly promising functional material in biomedicine and cosmetic products. BOC Sciences offers a variety of PLA-based application solutions based on market demands and application trends, covering multiple forms from microspheres to composite materials. These are widely used in key scenarios such as facial contour filling, skin repair, tissue regeneration, and cosmetic effect delivery. By tailoring PLA microsphere structure, release behavior, and composite system design, we help clients develop high-performance, personalized end products to enhance market competitiveness and customer satisfaction.
Facial Contour Fillers
PLA microspheres, as core components of facial fillers, offer excellent shaping capability and long-lasting filling effects. They can address facial depression, contour remodeling, and elasticity enhancement. The controlled degradation process stimulates collagen regeneration, and they are widely used in non-surgical filling of nasal bridge, chin, nasolabial folds, etc., ensuring both safety and natural aesthetics.
Collagen Stimulators
PLA materials degrade slowly in the body while inducing fibroblast proliferation and new collagen formation, making them safe and effective collagen-stimulating ingredients. They are widely used in medical aesthetics to improve skin elasticity, texture, and reduce fine lines, serving as a key component in multifunctional anti-aging products.
Multifunctional Cosmetic Microspheres
By encapsulating active ingredients such as vitamins, peptides, and growth factors, PLA cosmetic microspheres achieve stable sustained release and enhanced skin penetration. They are suitable for high-end serums, ampoules, and device-assisted cosmetic liquids. Their particle size and release profiles can be flexibly customized based on formulation needs to enhance the technological appeal and user experience of skincare products.
Postoperative Repair Aids
In medical aesthetics and post-surgical recovery, PLA microspheres can serve as supportive or sustained-release carriers, embedded with hyaluronic acid, repair peptides, and soothing agents for stable release and accelerated tissue repair. Their injectability and good local tolerance make them popular in postoperative repair patches and injectable formulations.
Skin Repair Carriers
PLA-based carriers can be used to develop products that restore skin barrier function, suitable for sensitive or damaged skin. By controlling the release of sebum regulators, moisturizing agents, and soothing ingredients, PLA microspheres effectively boost the skin's self-defense capability and improve its tolerance and barrier function.
Composite Mask Materials
BOC Sciences can develop flexible biofilms and membrane fabrics based on PLA, suitable for bio-functional masks, patch dressings, and wound coverings. These membranes combine biodegradability with good skin affinity and can carry active agents to provide transdermal delivery, moisturizing, and sustained release effects.
Sustained Release Drug Delivery Systems
PLA microspheres can act as sustained-release carriers for various drugs (e.g., antibiotics, hormones, anti-cancer agents), supporting injectable, subcutaneous implantation, ophthalmic, and localized targeting dosage forms. Their degradation rate and drug loading capacity can be precisely controlled to enhance drug duration, reduce dosing frequency, and minimize side effects.
Tissue Engineering Scaffold Materials
With excellent mechanical properties and processability, PLA can be used to construct porous structures for tissue engineering scaffolds, supporting cell adhesion, growth, and tissue regeneration. Application areas include skin regeneration, cartilage repair, vascular engineering, etc., making PLA one of the core foundational materials in regenerative medicine development.
FAQs
What is PLA injection?
PLA injection is a cosmetic or medical treatment in which polylactic acid microspheres are injected into targeted areas to fill wrinkles, restore facial volume, and stimulate collagen production through controlled biodegradation.
How does polylactic acid degrade?
Polylactic acid (PLA) degrades mainly through hydrolysis in the body or natural environment, where ester bonds are broken down into lactic acid monomers. Lactic acid is then metabolized into carbon dioxide and water by the human body, making PLA highly biodegradable. Its degradation rate is influenced by temperature, humidity, pH value, and material structure (such as molecular weight and crystallinity), making it widely applicable in absorbable implants and eco-friendly materials.
How to make polylactic acid?
Polylactic acid is typically synthesized via ring-opening polymerization (ROP) of lactide or through direct polycondensation. The most common method involves using L-lactic acid or D,L-lactic acid as raw materials, polymerized in the presence of metal catalysts to produce high molecular weight PLA. The process allows control over molecular weight, stereoregularity, and final performance by adjusting reaction conditions, making it suitable for developing medical devices, drug carriers, and premium cosmetic materials.
Is PLA used for drug delivery?
Yes, PLA is widely used in drug delivery systems, especially for sustained and targeted delivery. Its biodegradability and biocompatibility make it an ideal carrier for small molecule drugs, proteins, and peptides. PLA microspheres or nanoparticles can be tailored in terms of particle size and degradation rate to achieve controlled release, effectively extending therapeutic duration, reducing side effects, and supporting various delivery forms such as injections, topical applications, and implants.