PDRN Preparation Services
BOC Sciences focuses on the extraction and preparation of high-quality polydeoxyribonucleotide (PDRN) products. With advanced biotechnology and a stringent quality control system, we are able to provide PDRN products with high purity and activity. We are committed to providing reliable PDRN solutions for industries such as pharmaceuticals, cosmetics, and biomedical research worldwide, covering the entire process from raw material selection, extraction process optimization, quality testing, to large-scale production. Leveraging cutting-edge molecular biology technology and comprehensive cGMP production facilities, we can meet the demands for different specifications and application levels of PDRN products, supporting the development of scientific research and commercial applications.
What is PDRN?
PDRN is a mixture of deoxyribonucleotides with a molecular weight ranging from 50 to 1,500 KDa, derived from rainbow trout (salmon) or salmon (chinook salmon) sperm DNA. The most common molecular weight is 80–200 KDa, with a Gaussian distribution peak at 132 KDa. Sperm is the ideal source for high-purity DNA as it avoids the risk of impurities such as peptides, proteins, and lipids that may be present in somatic cells. Additionally, plant-derived PDRN can be extracted from microalgae and Platycodon, offering traceability and ensuring product quality and safety. PDRN has shown remarkable efficacy in addressing skin issues, effectively treating sensitive skin, redness, acne, and more. It also has powerful reparative functions, promoting the regeneration of various growth factors such as EGF (epidermal growth factor), FGF (fibroblast growth factor), and VEGF (vascular endothelial growth factor). Currently, PDRN is widely used in skin repair, anti-aging treatments, wound healing, bone repair, and ophthalmic treatments.
Advantages of BOC Sciences in PDRN Preparation
Advanced Extraction Technology
Utilizing optimized cell lysis and DNA purification techniques to ensure PDRN has high purity and bioactivity.
Strict Quality Control
Compliant with cGMP production standards, all PDRN products undergo rigorous quality testing to ensure stability and safety.
Diverse Product Supply
Offering various forms of PDRN products, including powders, liquids, injectable grades, and cosmetic grades, suitable for different research and commercial applications.
Custom Services
Supporting customers with customization of PDRN specifications, concentrations, and purity to meet specific experimental or industrial production needs.
Extensive Production Experience
Accumulating years of experience in PDRN extraction and preparation, ensuring efficient production and product quality.
Global Supply Chain
Having a strong global supply chain network ensures PDRN products are delivered on time worldwide.
Flexible Scalable Production
Supporting small-scale research to large-scale commercial production, meeting the diverse needs of customers.
Professional Technical Support
Providing expert technical consultation and support to assist customers in solving technical challenges during the R&D process.
PDRN Raw Materials Provided by BOC Sciences
BOC Sciences offers PDRN products in various specifications, including powders, liquids, injectable grades, and cosmetic grades, with the option to customize specific molecular weights or purities based on customer needs. With strong production capacity and flexible custom services, we support the R&D and application of PDRN in multiple industries such as pharmaceuticals, medical aesthetics, and health foods, helping global research institutions and enterprises advance biomedicine and regenerative medicine development.
Powder PDRN
Prepared using advanced lyophilization technology, offering a longer shelf life and convenient transportation and storage, suitable for pharmaceutical, gene therapy, cell culture, and tissue engineering fields.
Liquid PDRN
Ready-to-use PDRN solution, typically undergoing strict sterile treatment and concentration optimization to ensure efficient application in biomedical research, cell culture, and drug development.
Animal-derived PDRN
Mainly extracted from fish tissues such as salmon, with high sequence similarity to human DNA, offering excellent biocompatibility.
Plant-derived PDRN
Mainly extracted from algae plants, using plant tissue engineering technology to avoid potential risks of animal-derived contamination and reduce the likelihood of immune rejection.
Injectable-grade PDRN
Undergoing rigorous sterilization and purification, compliant with pharmaceutical-grade production standards, and suitable for medical aesthetics and regenerative medicine fields such as skin fillers, anti-aging treatments, and tissue repair.
Topical-grade PDRN
With good permeability, it promotes cell regeneration, improves skin barrier function, and accelerates wound healing. It is primarily used in skincare and wound repair products like dressings, gels, and medical-grade skincare products.
Cosmetic-grade PDRN
Used in products such as serums, masks, and creams, cosmetic-grade PDRN helps improve skin elasticity, reduce fine lines, and enhance skin repair capacity.
c-PDRN
c-PDRN is a derivative of PDRN more commonly used in skincare products, ideal for those who wish to enhance repair without opting for injectable PDRN.
PDRN Extraction Technology at BOC Sciences
BOC Sciences utilizes advanced biotechnology and stringent quality control systems to efficiently and safely extract high-purity PDRN. Our PDRN extraction process encompasses several key steps, including raw material processing, cell lysis, DNA extraction, DNA fragmentation, purification and concentration, quality testing, terminal sterilization, and drying and packaging. Each step is strictly optimized to meet the high standards of industries such as pharmaceuticals, cosmetics, and biomedical research.
Raw Material Processing
Strict selection of animal or plant tissues as raw materials, preserving them at low temperatures to prevent degradation, followed by tissue cleaning, impurity removal, and crushing to ensure efficient extraction.
Cell Lysis
Using gentle methods like enzymatic digestion and ultrasonic disruption to maximize DNA integrity and enhance PDRN recovery and quality.
DNA Extraction
Employing membrane filtration, chromatography separation, and washing techniques to remove impurities and ensure high-purity DNA, maintaining the bioactivity of PDRN.
DNA Fragmentation
Using enzymatic cleavage or physical shearing methods to fragment DNA into different molecular weight ranges of PDRN, enhancing its bioavailability.
Purification and Concentration
Applying chromatography separation and ultrafiltration concentration to remove low molecular weight fragments and endotoxins, ensuring high purity and bioactivity of PDRN.
Quality Testing
Strict quality testing including molecular weight determination, purity testing, endotoxin, and microbial contamination testing, ensuring that PDRN meets high standards.
Terminal Sterilization
Using high-temperature high-pressure, filtration, or irradiation sterilization to ensure the product is sterile without affecting its bioactivity.
Drying and Packaging
Using lyophilization or liquid packaging, employing vacuum freeze-drying technology to preserve PDRN structure and activity, ensuring long-term stability and safety.
GMP Scale Manufacturing Capacity of PDRN
BOC Sciences has advanced PDRN large-scale production systems capable of meeting the demand from laboratory research to large-scale commercial production. We have established production facilities that comply with international standards, equipped with efficient nucleic acid extraction, purification, concentration, and drying equipment, ensuring high purity, high activity, and low endotoxin levels in PDRN products. During the production process, we adhere to a strict quality control system, with every step—from raw material selection to final product packaging—subjected to rigorous testing to ensure compliance with cGMP requirements. In addition, our automated production lines enable efficient and stable large-scale production to meet the growing global demand for PDRN.
PDRN Quality Testing Services at BOC Sciences
BOC Sciences always upholds a stringent quality control system, providing customers with high-purity, high-activity, and reliable PDRN products. Our PDRN quality testing services cover various stages, including raw material screening, production process monitoring, and final product testing, ensuring PDRN meets industry standards and customer needs. We use advanced analytical technologies and high-end instruments for testing, ensuring the product meets key quality indicators such as good biocompatibility, no contamination, and no degradation.
Advanced Analytical Platform
Gel Electrophoresis Dynamic Light Scattering (DLS) High-Performance Liquid Chromatography (HPLC) Capillary Electrophoresis (CE) UV-Vis Spectrophotometry Agarose Gel Electrophoresis Quantitative PCR (qPCR) Capillary Electrophoresis
Analysis Projects
Molecular Weight Analysis Purity Analysis Endotoxin Testing Microbial Contamination Testing DNA Fragmentation Analysis Solubility Testing Accelerated Stability Testing Long-term Stability Testing Sterilization & Sterility Validation
Research Applications Supported by PDRN Raw Materials
BOC Sciences offers high-quality PDRN raw materials in various specifications, widely used in many research fields, including tissue repair, skin regeneration, anti-inflammatory treatments, anti-aging, cell growth promotion, regenerative medicine, neuroprotection, and gene therapy. With advanced extraction technology and a rigorous quality control system, our PDRN raw materials meet the R&D needs of various products, helping scientists, pharmaceutical companies, and biotechnology enterprises explore innovative applications. Below are the key applications of PDRN in multiple research and product areas:
Medical Mask Ingredients
PDRN has attracted significant attention in the field of medical skincare products due to its excellent repair and regeneration capabilities. It can promote fibroblast proliferation, enhance collagen synthesis, and help soothe sensitive skin.
Medical Gel Ingredients
The water-soluble nature of PDRN and its ability to promote cell regeneration make it an important component in medical gel formulations. PDRN gels can be used to accelerate wound healing, postoperative care, skin barrier repair, and improve scar formation.
Skin Booster Ingredients
PDRN is widely used in skin medical treatments such as skin booster products. It can deeply hydrate, repair damaged cells, promote skin elasticity restoration, and reduce fine lines and wrinkles.
Baby Skin Booster Ingredients
Baby injections are a new type of skin repair treatment, typically used to enhance skin hydration, smoothness, and radiance. As a core ingredient, PDRN stimulates skin cell regeneration, strengthens the skin's barrier repair ability, and leaves the skin smooth, like that of a baby.
Cosmetic Ingredients
PDRN's biological repair characteristics make it promising in cosmetic products, such as skincare foundations, repairing lipsticks, and functional BB creams. It provides antioxidant, moisturizing, and repair functions, improving skin comfort.
Ophthalmic Solution Ingredients
PDRN is of interest in ophthalmology due to its anti-inflammatory, antioxidant, and cell regeneration properties. Studies suggest that PDRN can help improve dry eye disease, corneal injury, and eye fatigue, contributing to the recovery of eye tissue health.
Health Supplement Ingredients
PDRN can be used in functional foods and dietary supplements. It has shown promising applications in areas like cell repair, immune modulation, and anti-aging, widely used in health supplements focused on delaying aging.
Regenerative Medicine Ingredients
PDRN can accelerate tissue repair and regeneration by activating adenosine A2A receptors and promoting the expression of growth factors such as VEGF and FGF. It is widely used in research for wound healing, burn repair, corneal repair, and bone tissue regeneration.
FAQs
What is the difference between polynucleotide and PDRN?
Polynucleotides are long-chain molecules formed by multiple nucleotides linked by phosphodiester bonds, typically as part of genomes or RNA. They can consist of various types of nucleotides, such as DNA or RNA. PDRN (Polydeoxyribonucleotide) refers to a polymer composed of deoxyribonucleic acid (DNA) monomers, commonly used in tissue repair, anti-aging, and other fields. The key difference between PDRN and regular polynucleotides is their origin and specific biological activity, with PDRN usually derived from fish (e.g., salmon) or other organisms.
What are the benefits of Polydeoxyribonucleotide?
Polydeoxyribonucleotide (PDRN) offers several potential benefits, including promoting tissue repair, anti-inflammatory effects, and improving blood circulation. It accelerates wound healing by promoting cell regeneration, repairing damaged tissue, and improving microcirculation. Additionally, PDRN exhibits antioxidant properties that may slow the aging process. PDRN is also thought to enhance the immune system, improve skin health, and is used in certain clinical treatments for soft tissue injuries and inflammation reduction.
Is salmon PDRN safe?
Salmon PDRN is widely considered safe, especially in clinical applications. Since it is derived from salmon DNA, it is typically prepared under strict quality control and non-toxicity assessments to ensure its safety and efficacy. However, some patients may have allergic reactions or discomfort to salmon PDRN, so it is recommended to perform an allergy test before use or use it under professional guidance. Overall, PDRN produced through standardized manufacturing and clinical validation shows good safety in most patients.