High Throughput ADME

To meet the ever-increasing number of compounds required in the drug discovery phase, BOC Sciences offers high-throughput ADME services to accelerate the lead optimization and drug discovery process. Utilizing state-of-the-art technology and advanced instrumentation, the company is able to provide cost-effective services with fast turnaround times.

ADME

ADME refers to the body's absorption, distribution, metabolism and excretion of drugs. The ADME properties of drugs determine the concentration, tissue distribution and metabolic pathways of drugs in animals or humans, reflect the dynamic changes of drugs in vivo, and provide an important basis for predicting the bioavailability and biological activity of drugs. In the whole process of drug discovery, the optimization of ADME properties of drug molecules is the most difficult part. Therefore, the analysis of ADME properties of compounds plays a key role in the success of drug development.

Fig. 1 ADME process

Drug discovery is a high-risk, high-cost, but also high-reward process. For a candidate drug with target activity and selectivity, if its ADME properties do not meet the drug-like requirements, the candidate drug cannot eventually become a drug. Therefore, the ADME properties of drugs are evaluated and optimized in the early stage of drug discovery, so that compounds that do not meet drug-like properties can be eliminated early, the success rate of research and development can be improved, and unnecessary investment and waste of resources in the later stage can be avoided.

In order to avoid unnecessary losses, BOC Sciences relies on its years of service experience to provide ADME services for routine compound screening, and can design experimental protocols according to specific needs of customers to facilitate the drug development process.

High-throughput ADME

Using high-throughput technologies, lead compounds can be rapidly identified and large batches of compounds can be screened in a cost-effective manner. Our highly automated ADME laboratory performs high-throughput ADME screening and analysis using fixed or custom methods to achieve rapid delivery of ADME results, optimizing ADME properties, potency and selectivity targets, thereby enabling customers to evaluate potential drug candidates make important decisions.

Our Advantages

• High quality and consistent data: We enhance our services to our diverse clients under robust protocols that generate high quality and consistent data.
• Ability to screen at scale: As a powerful tool for early drug discovery, high-throughput technologies make it possible to screen large batches of compounds quickly and efficiently.
• Fast screening: High-throughput ADME analysis enables prioritization of drug candidates based on their ADME properties while optimizing their efficacy at an early discovery stage. This approach improves the overall quality and likelihood of success of drug candidates, thereby shortening the drug discovery and development process.
• Personalized customized program: Our high-throughput ADME service can be customized according to the specific requirements of customers to meet the special service needs of different customers.
• Competitive price: Our services are extremely cost-effective.
• First-class expert technical team: The team is professional and experienced.

Our Service Steps

The ADME screening process mainly includes the following five steps:

• Well plate management of compounds to be screened
• Compound MS/MS Method Optimization
• High-throughput ADME experiments and sample cleanup
• Raw LC-MS/MS data collection and processing
• Archiving of processed ADME data

Our Service Scopes

We provide high-throughput ADME services in the following areas:

• Water Solubility (Thermodynamics & Kinetics)
• Metabolic stability (microsomal stability, plasma stability, hepatocyte stability, etc.)
• Permeability (PAMPA)
• Protein binding (plasma, microsomes, brain tissue, etc.)
• CYP inhibition
• CYP Analysis

Relying on rich experience and advanced instruments, BOC Sciences can provide robust and cost-effective high-throughput ADME services. We can also customize solutions according to the different needs of customers.